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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A nephroblastoma occurred in the evolution of a case of Beckwith's syndrome. This rare association is not fortuitous. The bifocal character of the tumor is noted for the first time in the Beckwith's syndrome; however, it has already been observed in other conditions, which are known to promote the development of nephroblastomas. Wilm's tumor is only one of the tumors which may be associated with Beckwith's syndrome. These morbid associations and certain histological features bring together some material for the understanding of the nature of the histo-genetic relationship between different aspects of constitutional pathology and tumors.
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PMID:[Association of a bifocal nephroblastoma with Beckwith's syndrome]. 18 38

The congenital mesoblastic nephroma is a distinct tumor entity, which should be clearly distinguished from Wilmus-tumor. The pure mesenchymal tumor is usually present at birth and palpated as a mass in the kidney. Macroscopically the tumor reveals a striking resemblance with an uterine fibroid. Histologically the tumor tissue ist characterized by 1. interlacing bundels of spindle cells with uniform cell nuclei and regular mitotic figures, 2. collagen fibres between the tumor cells, 3. an angiomatous marginal zone, no tumor capsule, 4. hematopoetic foci and dysplastic glomeruli and tubuli in areas where normal kidney parenchyma mixes with tumor tissue, 5. small myxomatous areas within in the tumor, 6. no invasion of blood vessels or pelvis. Prognosis of the congenital mesoblastic nephroma is much better than in Wilms-tumor. Metastases have not been described so far. If, however, the tumor tissue is incompletly removed during operation, the neoplasm may recur and prove fatal. Ultrastructural and DNA cytophotometric studies suggests a low grade malignancy rather than a truely benign behaviour of this tumor.
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PMID:[Congenital mesoblastic nephroma - a semimalignant fibroleiomyomatous kidney tumor of the newborn (author's transl)]. 18 64

The histology of a spontaneously occurring neoplasm of the rat kidney conforming to a classification of nephroblastoma is described and compared with that of N-nitrosodimethylamine-induced renal mesenchymal tumors. This rat nephroblastoma was an encapsulated epitheloid neoplasm with a uniform histologic pattern. Clumps of densely crowded, hyperchromatic cells frequently associated with central, well-differentiated ducts were supported by a less cellular, interconnecting stroma of loose areolar or mature fibrous connective tissue. Neoplastic cells were organized into primitive, ill-defined tubular formations. The neoplastic cell component strongly resembled metanephrogenic blastema. In contrast, the renal mesenchymal tumor was nonencapsulated and consisted of a heterogeneous mixture of connective tissue elements including fibroblast-like spindle cells, smooth muscle, and embryonic mesenchyme that engulfed and sequestered preexisting renal tubules and glomeruli. The separate morphologic identities and apparently unrelated existence of rat nephroblastoma and renal mesenchymal tumor were stressed. The rat nephroblastoma morphologically resembled the malignant epithelial component of human Wilms' tumor, whereas rat renal mesenchymal tumor appeared to have counter-parts in the mesenchymal component of Wilms' tumor and in congenital mesoblastic nephroma (leiomyomatous hamartoma) of infancy. The histologic descriptions of previously recorded occurrences of spontaneous and experimentally induced rat neoplasma classified as nephroblastoma or its synonyms were reevaluated in comparison to the present case. In all but four instances, in which sufficient histologic detail was provided in previous reports, a consistent histologic pattern emerged for this neoplasm in the rat.
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PMID:Nephroblastoma in the rat: histology of a spontaneous tumor, identity with respect to renal mesenchymal neoplasms, and a review of previously recorded cases. 18 69

A woman who had received successful therapy for Wilm's tumor of one kidney in childhood developed renal cell carcinoma in the opposite kidney 21 years later. Such an occurrence has not been reported previously. A discussion of the differential diagnosis of calcified renal mass lesions and the angiographic differentiation between Wilms's tumor and renal cell carcinoma is presented. The possible relationship between these two primary renal tumors is considered.
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PMID:Renal cell carcinoma in a patient successfully treated for Wilms's tumor. 18 47

Treatment results for 32 children with Wilms' tumor seen at the JCRT, CHMC and SFCI from January 1, 1971, through December 31, 1975, are presented. Indications for and technical details of irridation are discussed. The uniform efficacy of irradiation in preventing local relapse in all patients presenting with unilateral disease despite tumor spill in nine is stressed. Actuarial survival of nearly 80% of all patients seen and followed for more than 2 years has been achieved. Eight of 14 patients with documented pulmonary relapse have been controlled with irradiation, chemotherapy and surgery. The importance of an aggressive multidisciplinary approach to this tumor is stressed.
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PMID:The increasing importance of radiation therapy in the improved prognosis of children with Wilms' tumor. 18 97

Ectopic tumor associated erythropoietin release was measured preoperatively and postoperatively in 36 Wilms' tumor patients followed for an average of three years. Erythropoietin assay results in plasma and urine were related independently to tumor stage as well as to the general clinical judgment following appropriate and exhaustive tests as to whether the disease was active or inactive at the time of the assay. Consistent erythropoietin plasma elevations were correlated with the presence of active disease in all stages of Wilms' tumor. Less consistent elevations were noted in urine specimens concomitantly obtained and assayed. This hormonal assay continues to be of consistent and long-term benefit in predicting or correlating disease recurrence or persistence in Wilms' tumor.
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PMID:The value of erythropoietin assay in the follow-up of Wilms' tumor patients. 19 May 73

Angiograms following renal trauma in a ten-year-old girl were highly suggestive of renal neoplasm, especially Wilms' tumor. There are striking similarities between arteriograms after renal trauma and those showing neovascularity.
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PMID:Abnormal renal arteriography after renal trauma. 19 Jul 48

A patient with a rare case of cardiac tumor in the right atrium secondary to Wilms' tumor of the right kidney, underwent open heart surgery and removal of the mass was presented. This is the 10th. case of intracardiac tumor secondary to renal malignancy. Careful auscultation of the heart is necessary in patients with malignancy in the kidney to detect the possible right heart metastases through the inferior vena cava. Cardiac symptoms precede the renal manifestations in most cases. Malignant renal metastases to the heart should always be in mind in space occupying masses of the right heart chambers.
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PMID:Metastatic Wilms' tumor in the right atrium propagated through the inferior vena cava. 19 Aug 13

Three cases of Wilms' tumor with inferior vena cava involvement are presented. All three cases were shown to have nonvisualization of the inferior vena cava on the initial intravenous pyelogram obtained by internal saphenous vein injection. The first case ended fatally, due primarily to delay in diagnosing extension of the tumor into the right atrium. There was no cardiac involvement in the other two cases, both of which were managed successfully. A right heart angiogram demonstrated intraatrial tumor in the first case and helped to identify the presence and extent of caval involvment in the other two. It is recommended that right heart angiography be performed in those cases of Wilms' tumor where the inferior vena cavagram shows non-visualization of the cava or suggests the presences of intraluminal tumor. The immediate availability of two separate surgical teams in the management of such cases is suggested.
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PMID:The role of right heart angiography in the management of selected cases. 19 Sep 56

Nephroblastoma, a tumour of the kidney, is most often observed in children; it always includes the nephrogenous tissue in any variant of its differentiation. Histogenesis of this neoplasm is multiform and complex. Its development from very immature pluripotential (polypotent) cells (possibly, at the level of blastodermic vesicle) is not ruled out. The histological classification of nephroblastomas, offered by the author, is based on the principles of differentiation of the tumour tissue and on its histogenesis and opens new perspectives for further investigation of neoplasms and for clinico-anatomic collations.
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PMID:[Problems of histogenesis and classification of nephroblastoma (Wilms' tumor) in children]. 19 Sep 82


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