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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The various aspects of this comparatively rare neoplasia are discussed on the basis of two cases of retroperitoneal liposarcoma and an analysis of the literature. Consideration are expressed on the clinical symptoms, the pathological anatomy, its marked tendency to evolve with repeated local relapses and the need to properly localise the mass and the feeding peduncles prior to the operation, so that radical exercise can be performed, since this leads to a more favourable long-term prognosis. The utility of radiotherapy, which leads to a lengthened period of freedom from the disease and to an increased survival time, is also stressed.
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PMID:[Retroperitoneal liposarcoma]. 101 22

A case of liposarcoma of the cheek in a 39-year-old man has been presented. This tumor, which is one of the most common malignant tumors of soft tissues in the body generally, is extremely rare in the oral regions. Initial surgical excision in this case was followed closely by a second more extensive local dissection in view of the pronounced tendency of the liposarcoma to infiltrate locally beyond the apparent limits of ite pseudocapsule. Early and adequate surgical intervention is most important in the long-term control of this tumor. Accurate histopathological diagnosis provides important information relative to the prognosis and preferred treatment.
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PMID:Lipsarcoma of the cheek. 106 58

The second reported case of primary paravesical tumor is described. A seventy-five-year-old man complained of increasing difficulty on urination. Physical examination revealed a visible aand palpable mass in the hypogastrium. The cystogram disclosed a unilateral crescent-shaped configuration of the urinary bladder. A tumor mass was surgically removed from the extraperitoneal paravesical space. The histologic diagnosis of the tumor was myxoid liposarcoma. A feature of primary paravesical tumor, which is derived from connective tissue, is that it manifests no symptoms or signs until the tumor attains considerable size. Primary paravesical tumor, heretofore unclassified, is a urologic entity.
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PMID:Liposarcoma of paravesical space. 114 46

Tumors in rats of the Nb strain, arising either spontaneously or after prolonged treatment with s.c. pellets of estrogen, were transplanted to establish whether hormone conditioning was required for their growth. Whereas all spontaneous tumors arising in males and many of those in females were autonomous on transplant, most of those arising in estrogenized rats continued to require hormones for growth after transplantation. The latter included carcinomas of the adrenal cortex, breast, pituitary ectopic tissue, ovary (thecomas), Leydig cells of testis, thymus, pancreas,salivary glands, oribital gland (fibroadenoma), liposarcoma, and lymphoma. Many of the tissues of origin of the tumors have not been considered to be under theinfluence of estrogens. A type of hormone-responsive tumor that was inhibited by estrogen and that grew only in normal rats is described. Ali estrogens tested, including estriol , were interchangeable in action. The incidence of the more common tumors of the adrenal, breast, and pituitary was very low in normal rats, but higher in females. All tumors were more common after estrogenization in both sexes, particularyly in older animals. The secretion of steroids and pitiutary hormones by many tumors led to obvious biological effects. Pituitary secretion led to severe lesions frequently associated with diseases in humans, but the signs of such diseases in the rat apparently were hormone dependent and disappeared if the tumor was removed. The overall results raised the possiblity that estrogens were not carcinogenic per se but stimulated the growth of previously altered cells and that, following their transplantation, this hormone requirement was retained. Irrespective of the mechanism of carcinogenesis, hormone-dependent tumor growth was not irreversible but was controlled in an unexpectedly wide spectrum of organs by exogenous estrogen. Host factors may play a major role in controlling the growth of many tumors and the ultimate course of the disease.
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PMID:Spontaneous and estrogen-produced tumors in Nb rats and their behavior after transplantation. 116 9

A case of ganglioneuroblastoma associated with malignant mesenchymoma is reported. The tumor originated from the retroperitoneum and was comprised not only of neuroblastoma and ganglioneuroma, but also of typical rhabdomyosarcoma, liposarcoma, undifferentiated mesenchymoma, as well as cartilaginous tissue. No distinct border existed between thses different components. The histogenesis of the tumor is discussed. We suggest that the tumor derived from a remnant of neural crest (ectomesenchyme).
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PMID:Ganglioneuroblastoma associated with malignant mesenchymoma. 118 58

Transplantable tumor lines were previously established from a variety of estrogen-induced tumors in Nb rats, including tumors of the adrenal cervix, salivary gland, and pancreas, a lymphoma, and a liposarcoma. Spontaneous tumors, however, were found to arise in untreated females and showed the same characteristics. Tumor growth was dependent upon or influenced by estrogen when assessed in estrogenized and unconditioned hosts. Intermitten estrogenization was effective, but tumor growth took place more slowly. The type of response observed led to a new classification of five types of hormone-responsive tumors including tumors inhibited by estrogen. Estrogen-dependent tumor cells might remain dormant indefinitely and not grow in unconditioned animals until stimulated to grow by estrogen. The growth rate of hormone-dependent adrenal carcinomas was related to the amount of estrogen. Tumor growth started more rapidly in the presence of low estrogen dose levels in old rats used as hosts than it did in young rats. Breast carcinomas required the largest amount of estrogen for growth, whereas ovarian thecomas would grow in normal females but not in males. The growth rate in conditioned hosts of most transplanted tumors (some have maintained hormone dependency over 10 years) increased over successive generations. Progression, however, towards a more autonomous state after repeated transplantations was remarkably slow, and a sudden change to autonomy was rarely noted. In contrast, transplants of 9,12-dimethylbenz(a)anthracene-induced mammary carcinomas progressed rapidly to autonomy. Fould's concept of progression (2, 3) has been discussed but the described classification of tumors under hormone influence apparently allows a more detailed analysis of definition of different types of progression.
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PMID:A classification of transplantable tumors in Nb rats controlled by estrogen from dormancy to autonomy. 118 86

Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posterior neck almost exclusively. Microscopically, it consists of an intricate mixture of lipocytes and uniform spindle cells within a matrix of mucinous material traversed by a varying number of birefringent collagen fibers. Ultrastructural studies in one case support the fibroblastic nature of the spindle cells. Followup information obtained in 63 patients with this lesion revealed a uniformly favorable clinical course, indicating that local excision is the treatment of choice, and that there is no need or reason for radical surgical procedures.
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PMID:Spindle cell lipoma. 119 70

A case is presented of a rare primary liposarcoma of bone localized to the major trochanter of the left femur of a 52-year-old female. Despite combined treatment with curettage and irradiation with a total dose of 4,500 rad the neoplasm showed rapid invasive growth with destruction of the bone, spread to the iliac fossa and outgrowth through the operation wound. Approximately 5 months after admission the patient succumbed due to widespread metastases in the lungs, liver and left kidney. The histopathology, clinical course and treatment of this rare neoplasm of the bone are discussed.
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PMID:Primary liposarcoma of bone. 121 Nov 24

An unusual case is reported of a liposarcoma of the renal capsule in a 7 year old girl. Initial radiological studies revealed a fatty tumor related to the lower pole of the kidney. Selective renal angiography located the tumor to renal capsule and demonstrated its malignant nature.
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PMID:Liposarcoma of the renal capsule in a 7 year old girl. 123 35

Retroperitoneal liposarcoma is a rare tumor in children and has been reported previously on only three occasions. This is the fourth such case, presenting with a large mass on the left side which displaced the sigmoid and ureters to the right. The patient was treated with surgery, radiotherapy, and chemotherapy. She is alive and well more than four years after therapy was instituted. A review of the pertinent literature cites the need for radio- and chemotherapy especially when surgical removal is incomplete.
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PMID:Retroperitoneal liposarcoma in a child. 124 78


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