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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pleomorphic carcinoma of the pancreas is a well defined histopathological entity characterized by non-cohesive, sarcoma-like growth pattern, and bizarre mono- and multinucleated tumor giant cells with abundant eosinophilic cytoplasm. Fifteen cases are identified in autopsy files of the Department of Pathology, Washington University School of Medicine, which represent 7.1% of all the non-endocrine pancreatic malignancies found at autopsy. Pleomorphic carcinoma is comparable to pancreatic adenocarcinoma in clinical features such as age, sex, and presenting symptoms except that it is more likely to occur in the body and tail of the pancreas, metastases invariably develop, hematogenous spread is more common, and the median survival is worse. Pleomorphic carcinoma could be distinguished from the pancreatic tumors that resemble giant cell tumor of the bone. Differential diagnostic features between it and amelanotic melanoma, hepatocellular carcinoma, choriocarcinoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, fibroxanthosarcoma, poorly differentiated epidermoid carcinoma, and giant cell carcinomas of the lung and thyroid are discussed.
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PMID:Pleomorphic carcinoma of the pancreas: an analysis of 15 cases. 87 Jan 68

Six cases of malignant abdominal neoplasm with extensive tumor involvement of the veins form the basis of this report. One case was a child with retroperitoneal liposarcoma. Proper therapeutic management in these cases was dependent upon a complete angiographic evaluation, including cavography. This procedure is virtually without complications and should, therefore, be done routinely in cases of abdominal neoplasms for evaluation of the operability, to confirm the angiographic findings indicating intravenous tumor invasion or extravenous compression, and as a primary examination in the assessment of possible or known abdominal tumors in children.
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PMID:Cavography in the management of malignant abdominal tumors. 87 Oct 87

After inoculating newborn W/Fu rats with adenovirus type 9, 27 of 27 females developed mammary fibroadenomas with a latency period of 14-25 weeks. No tumors were observed after inoculation with adenovirus type 5 or in males with the type 9 inoculation. After persistence of the tumors for 3-14 months, malignant transformation of the stroma resulted in different types of sarcoma in three rats: fibrosarcoma, round-cell liposarcoma, osteosarcoma and malignant mesenchymoma. In another animal the stroma of a fibroadenoma was highly cellular, suggesting a transition into fibrosarcoma. Malignant transformation of the epithelial component was not observed. Tumor cells contained adenovirus type 9-specific T-antigen, and rats with transplanted tumors were immunized to T-antigen. Mammary fibroadenomas without signs of malignant transformation developed in eight of nine female rats inoculated with adenovirus type 9 at an adult age. Neonatal thymectomy and total body x-irradiation neither significantly shortened the induction time of adenovirus 9-induced fibroadenomas nor increased the frequency of malignant transformation in females. One lipoma and one highly differentiated liposarcoma, however, appeared in two male rats. The results provide an example of the progression of a virus-induced benign tumor into a malignant neoplasm.
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PMID:Studies on adenovirus type 9-induced mammary fibroadenomas in rats and their malignant transformation. 87 51

In a study of 256 non-epithelial neoplasms involving the nasal cavity, paranasal sinuses and nasopharynx, only two lesions were classified as adipose tissue tumors (one lipoma and one liposarcoma). The lipoma was found incidentally when tissue removed from the maxillary sinus was studied histologically, the patient having been treated with a Caldwell-Luc procedure for maxillary sinusitis. The liposarcoma produced a large mass involving the nasal cavity, maxillary sinus, ethmoid area, hard palate and maxillary, temporal and sphenoid bones. The tumor extended into the cranial cavity and eventually led to the patient's death. The problems involved in histologically differentiating liposarcomas from other lesions are discussed. Even though adipose tissue tumors are among the most common soft tissue neoplasms, these lesions rarely occur in the nasal cavity, paranasal sinuses and nasopharynx.
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PMID:Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologyic study. VIII. Adipose tissue tumors (lipoma and liposarcoma). 90 42

A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added. The system evolved was based on examination of 1215 cases of 13 types of soft tissues sarcomas, primarily in the extremities (fibrosarcoma, liposarcoma, etc.). Nine stages are described, and they are correlated with survival in the cases reviewed. The staging system now can be used for case evaluation for therapy determination and for intercomparison of series of patients as to incidence of different kinds of tumors, effects of treatment, and survival.
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PMID:A clinical and pathological staging system for soft tissue sarcomas. 90 70

Two unusual cases of meningioma with extensive vacuolization have been studied by light and electron microscopy. There were two kinds of vacuoles in the tumor cells which had the characteristic ultrastructure of meningioma as well. The smaller intracytoplasmic vacuoles were lipid droplets, while the larger, more prominent vacuoles were found to be extracellular spaces probably containing plasmatic fluid. The tumor cells were very much stellate with extremely thin and long cytoplasmic processes having desmosome junctions and forming cavernous intercellular spaces, some of which contained collagen fibers and fibrils. Although the xanthomatous change has been well known, the latter features provide a resonable interpretation for the histology of the present tumors and fat-negative vacuoles in the ordinary meningiomas. The picture may be recapitulation of the subarachnoid structure. Furthermore, recognition of this type of meningioma is practically important especially in frozen section diagnosis not to misinterpret the tumor as liposarcoma, chordoma or metastatic adenocarcinoma.
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PMID:Vacuolated meningioma. A light and electron microscopic study. 91 Jun 29

This report is the first description of a secondary ovarian liposarcoma. The primary growth was in the mediastinum. The growth rate of the ovarian tumor was very rapid, but the patient died of cardiopulmonary causes. The mode of spread is discussed, and it probably occurred by transcelomic migration and surface implantation.
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PMID:Secondary liposarcoma of the ovary. 92 91

A case of liposarcoma, which originated primarily in the left infraauricular area and infiltrated to the posterior fossa, was reported. The patient was a 25-year-old housewife, who was admitted because of symptoms of intracranial hypertension. She showed left facial palsy and deviation of the tongue to the left without any cerebellar signs. Neurological examinations suggested a mass lesion in the posterior fossa. Suboccipital craniectomy was performed and the tumor sized 4 X 4 X 3 cm in the extradural space was partially removed. Microscopically, the tumor consisted of lipoblasts and diagnosed as liposarcoma. Intracranial liposarcoma, whether primary or secondary, is very rare and only several cases have been reported.
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PMID:[Intracranial extradural liposarcoma in the posterior fossa--a case report (author's transl)]. 94 71

A 57-year-old female with a large retroperitoneal tumor was atutopsied. She showed through the entire course of illness marked leukocytosis with the appearance of immature marrow cells, and this finding was hematologically interpreted as granulocytic leukemoid reaction. An intermittent pyrexia was also seen without infective etiology. The histologic diagnosis of the tumor was liposarcoma of the pleomorphic type. The tumor showed extensive necrosis, but no metastatic invasion was found. So-called leukemoid reaction appears sometimes together with malignant neoplasms. The majority of these tumors show widespread bone marrow metastases, and without bone marrow invasion they only rarely induce this reaction. Besides it is not common for leukemoid reaction to be evoked by the development of malignant mesenchymal tumors except for malignant lymphomas. The pathophysiologic process of the present of the present case is thought to be a rare occurrence.
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PMID:An autopsy case of liposarcoma with granulocytic leukemoid reaction. 96 20

Liposarcoma is a rare tumor in the head and neck. No previous report of its occurrence in the tongue is found at the time of this writing and this prompts its presentation. Significant in its management is wide surgical excision. Irradiation may be effective in some metastases. Prognosis is best in well differentiated forms.
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PMID:Liposarcoma of the tongue. 99 79


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