Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The early (dynamic) and late (static) renal images obtained with 99mTc-dimercaptosuccinic acid (DMSA) were utilized to evaluate renal cortical malignant tumors in 30 cases of renal cell carcinoma each of which had been confirmed by operation or autopsy. Early images, performed 20--50 seconds after radionuclide administration, demonstrated abnormal vascular pools in the cortex. A cold area without DMSA uptake was demonstrated on the 2-hour or late images, reflecting a non-functioning renal mass. Lesions demonstrated with combined early and late images showed a good correlation with those demonstrated by renal angiography in 25 out of 27 cases. However, when almost all the renal tumor was replaced by necrotic lesions, the early image did not reveal hypervascularity. When a highly vascular renal tumor extended to the perinephric tissues, the tumor area was sometimes overestimated on the early image. It is almost impossible to diagnose renal cell carcinoma using radionuclide imaging alone. However, 99mTc-DMSA renal studies, using both early and late imaging, have proven to be a useful, noninvasive adjunct in the detection of malignant cortical lesions.
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PMID:Successful visualization of cortical malignant lesions on renal scintigram using 99mTc-dimercaptosuccinic acid. 47 42

Thoracoscopy with a single opening was carried out under general anesthesia with a cold light thoracoscope of 7 mm in diameter. Biopsies were taken under visual control for optical and electron microscopic examination. In a series of 40 mesotheliomas, 30 patients with pleural effusion underwent 36 thoracoscopies. In 29 patients the macroscopic lesions were compatible with the diagnosis of mesothelioma. The most specific aspects consisted in white-yellowish nodules, almost translucent, arising from the parietal pleura (9 patients). Another typical pattern, a dense pleural thickening, was found in 10 patients. In the remaining patients, the lesions observed were less specific. The biopsy was positive in 35/36 thoracoscopies (97%). A talc poudrage was carried out in 10 patients: their mean survival was 458 days. In ten matched mesothelioma patients who underwent pleurectomy the mean survival was only 395 days. In 12 patients at an early stage, the visceral pleura was not involved by the tumor: their mean survival was 636 days. In 11 patients both parietal and visceral pleura were involved by the tumor: their mean survival was 138 days: (p less than 0,001). It is concluded that in mesothelioma pleural effusions, thoracoscopy is a safe and efficient procedure in order to reach a precise diagnosis, prognosis and efficient palliative treatment of the effusion.
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PMID:[Thoracoscopy in pleural mesothelioma. Diagnostic, prognostic and therapeutic interest (author's transl)]. 55 11

The spontaneous release of tumor cell antigens from the cell surface into the circulation has been proposed as a mechanism whereby tumors may escape the immune response of the host. In this study we have found that Ehrlich ascites tumor cells after removal from the host (mouse) spontaneously release significant amounts of cell surface components during incubation for 1 h in cold isotonic buffer. Immunodiffusion studies revealed that immunoglobulin G (IgG) and a complement component (C3) are included in this spontaneously released material. These surface-bound humoral immune components are apparently released in the form of a high-molecular-weight aggregate (cell coat particle) as shown by ultracentrifugation and ultrafiltration experiments. Precipitation of IgG from the cell coat particle preparation with antibodies directed against mouse IgG followed by detergent gel electrophoresis of the immune precipitate revealed five major bands in addition to the heavy and light chains of IgG. These results suggest that host IgG is tightly bound to several other components at the cell surface, perhaps in the form of immune complexes. IgG is localized on the tumor cell surface in a highly heterogenous pattern with the appearance of patches and caps in some cells as shown by immunofluorescence analysis. The possibility that humoral immune components bind to the tumor cell surface and result in the shedding of high-molecular-weight aggregates of cell surface antigens into extracellular fluids is discussed.
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PMID:The spontaneous release of a high-molecular-weight aggregate containing immunoglobulin G from the surface of Ehrlich ascites tumor cells. 57 Oct 32

The authors present a retrospective study of 110 patients operated for adenocarcinoma of the thyroid between 1950 and 1975, and submitted to standard postoperative radiotherapy. Clinical manifestations are poor and preoperative scintigraphy display a cold tumor in 80 percent of those performed. The preoperative cytodiagnosis confirms malignancy in 90 percent of cases approximately, thereby reducing the number of complementary reoperations. In the latter the rate of complications. Increases from 25 percent to 44 percent. Three are twice as many recurrent nerve palsies and parathyroid resections in total thyroidectomies as compared to subtotal. However after radical resection local recurrences and metastases are 4 times less frequent. Under combined radio-surgical treatment 82 percent of patients are alive with a mean survival time of 9.4 years; 9 percent have died of their disease after a mean 4.1 years and 9 percent have died of an unrelated condition an average 7.2 years after. The authors favor total or near-total, i.e. extracapsular homolateral and intracapsular controlateral, thyroidectomy for follicular and papillar adenocarcinomas alike, followed by local radiotherapy and destruction by 131 iodine (Acta chir. belg., 1977,76, 553-561).
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PMID:Surgery of differentiated thyroid adenocarcinomas. 59 89

Findings on thyroid scintigram were compared with results of thyroid palpation and size and location of C-cell disease in 68 thyroid lobes of 35 patients with familial medullary thyroid carcinoma (MTC) and high basal or stimulated plasma calcitonin values. Rectilinear scans showed cold nodules in 24 (35%) of 68 lobes. In three lobes, the cold nodules did not coincide with MTC (2 macrofollicular adenomas, 1 colloid goiter). Thus, the true positive rate for rectilinear scans was 31%. Palpation identified nodules in 20 lobes (29%), but the true positive rate was only 26%. Patients with MTC have high basal or stimulated calcitonin values long before the tumor is detectable by scan or even later by palpation. When the tumors were large enough to be seen on thyroid scans, the most frequently encountered single pattern was that of symmetrically located cold nodules in the middle of otherwise normal thyroid lobes. This pattern, if encountered in a thyroid scan, should raise the suspicion of MTC.
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PMID:Thyroid scintigram in familial medullary carcinoma of the thyroid gland. 65 81

Carcinogenicity of an aqueous extract of bracken was studied in inbred strain ACI rats. In Experiment 1, Group 1 rats received a diet containing unprocessed dry bracken powder for 3 months, Group 2 received the boiling water extract of dry bracken as drinking water for 16 months, Group 3 received the cold water extract of dry bracken as drinking water for 16 months, and Group 4 received a diet containing the concentrated boiling water extract of dry bracken during the whole experimental period. Rats in Experiment 2 also received a diet containing the boiling water extract of dry bracken. A control group was fed a normal diet. Majority of the animals in Group 1 developed multiple ileal tumors, such as adenomas and adenocarcinomas. In Group 2, 6 of 11 rats which survived beyond 7 months developed tumors in either the ileum or urinary bladder, or in both. Rats in Group 3 had no tumor. In Group 4 and in Experiment 2, all the animals except 1 rat in Experiment 2 had urinary bladder tumor. Furthermore, almost all the rats in these groups had simultaneously ileal tumors. Based on these results, it may be assumed that the carcinogen in bracken is extractable in boiling water and is most probably also water-soluble.
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PMID:Carcinogenicity of boiling water extract of bracken, Pteridium aquilinum. 66 38

We obtained 246 cold cup biopsies from pre-selected sites of apparently non-tumor-bearing bladder urothelium from 82 patients who presented with bladder cancer for the first time. Of 75 patients with transitional cell carcinoma 32 (43 per cent) suffered coincidental urothelial abnormalities, the most common being atypia. Significant abnormalities occurred more commonly (77 per cent) in association with high grade tumors than with low grade tumors (15 per cent).
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PMID:Biopsy of apparently normal urothelium in patients with bladder carcinoma. 71 98

Natural cell-mediated cytotoxicity, observed on co-cultivation of peripheral blood lymphocytes (PBL) with malignant melanoma tumor cells (M4), is described. The activity was inhibited when PBL were cultured in autologous serum. Studies using competitive inhibition with cold targets and stimulation of PBL with other tumor cell lines failed to detect specificity.
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PMID:Stimulation of human NK-cell activity by cultured cells. I. Response of normals. 72 15

The total binding capacity of the cell receptors and not only the fraction required to elicit physiological response was detected and it is shown that specific receptors filled by endogenous estradiol were detected along with the unfilled sites. Changing the temperature of the incubation media altered intracellular distribution of bound estradiol. Late nucleolar retention of estradiol was shown after its release from nuclear protein. This unexpected finding may be a key event. Tumor tissues were obtained from 40 primary breast cancers, 2 endometrial carcinomas, and 1 lung and 1 gastric cancer; 2 normal human spleens, 2 mouse livers, and 1 breast from a 5-month pregnant women were processed. Tissue samples were transferred to a cold flask containing phosphate-buffered balanced salt solution. Further details of preparation are given to show typical estradiol-target cells containing variable amounts of specific estradiol-receptors. For immunofluorescence staining and indirect technique was used to show the in situ estradiol localization. The fluorescence staining showed 3 patterns. Cells incubated in the cold mostly displayed a bright, homogeneously diffuse fluorescence of the cytoplasm with the nuclear area unstained. There were some negative cells. The 2nd pattern of fluorescence was shown by those incubated at room temperature. Cytoplasmic staining was more marked and nuclear areas showed bright-fluorescent light stippling. A 3rd staining pattern was seen after slow postincubation warming up to 37 degrees C when increased nuclear staining occurred. Some cells did not show any nuclear labeling despite the clear cytoplasmic fluorescence. Preparations of human spleen, nontarget tumors, or mouse liver had no fluorescent cells. All fluorescent stainings were prevented by preincubation and washing in media containing Nafoxidine and N-ethylmaleimide. Control experiments confirmed the immune specificity of the detection of estradiol. Breast tissue cells from a pregnant women showed moderate cytoplasmic and faint nuclear fluorescence before incubation with estradiol, after which cytoplasmic staining was reinforced. Cells from the premenstrual beast cancers sometimes showed fluorescence without exposure to estradiol.
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PMID:Detection and dynamic localisation of estradiol-receptor complexes in intact target cells by immunofluorescence technique. 78 84

Sixty-two of 1242 patients with M components were found to have lymphoma. There were 33 patients with immunoglobulin M(IgM), 20 WITH IgG, 5 with IgA, and one patient with Bence Jones protein M components. Three patients had biclonal gammopathy. The types of lymphoma were: lymphocytic, 31; histiocytic, 12; mixed cell, 4; stem cell, 2; Burkitt's, 1; Hodgkin's disease, 9; and unclassified, 3. All patients were in stages III or IV of lymphoma, and the average duration of disease was 29.3 months when M components were detected. Anemia, abnormal peripheral blood lymphocytes, and lymphomatous involvement of the bone marrow were especially common among patients with IgM M components. Osteolytic lesions were found in 12 patients and osteosclerotic lesions in one. A second malignancy occurred in eight patients. The level of M component was below 1.0 gm/dl in 55 per cent of patients. Significant suppression of normal immunoglobulin levels in the serum was noted in 4 and 16 patients with IgG and IgM components, respectively. Bence Jones proteinuria was found in 19 per cent, cryoglobulinemia in 11 per cent, and cold agglutinins, all of anti-i specificity, in 10 per cent of the patients. Most of the M components decreased during therapy. Only two M components gradually increased. The mean survival of 39 patients who died was 10.4 months. The living patients have been followed for a mean period of 21.2 months. The presence of M components in lymphoma may suggest B cell origin of the tumor but the coexistence of plasma cell dyscrasia cannot be ruled out.
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PMID:M components associated with lymphoma: a review of 62 cases. 82 10


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