Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Areas of chordoma and chondrosarcoma have been reported extensively in the same tumoral mass located in espheno-palatine region. The same association in long bones of the extremities have been reported recently, with the name of "chordoide sarcoma", "parachordoma" or "chondroid chordoma". We present a case of "chordoid sarcoma". The cells of this tumor have morphologic features of chordoma and chondrosarcoma in both the optical and ultrastructural study. However some morphological, radiological and clinical aspects, suggest that this tumor possesses characteristics that define it as a separate entity.
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PMID:[Chordoid sarcoma of the femur. Electronic and optical microscopy study of a case]. 123 79

Extraskeletal myxoid chondrosarcoma is a rare tumor of cartilagenous origin, with only 41 previously reported cases. It has a distinctive histologic pattern and should be distinguished from chondrosarcoma of bone because of its different behavioral pattern. The light microscopic, histo-chemical and electron microscopic features of such a tumor are reported.
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PMID:Extraskeletal myxoid chondrosarcoma: a clinicopathological study. 125 8

The authors present a case of chondrosarcoma involving the lateral mass of the C-2 vertebra, treated by an apparent total removal of the tumor. A review of the literature revealed that these patients can be cured in a significant number of cases if a radical removal is accomplished.
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PMID:Chondrosarcoma of the cervical spine. Case report. 125 39

Eight cases of surgically and pathologically verified extraskeletal (soft tissue) chondrosarcoma were analyzed with regard to clinical and X-ray features. Their cardinal clinical aspects included presence of a local soft tissue mass and gradual enlargement of the mass accompanied by increasing pain. The X-ray signs were formation of a soft tissue mass, various forms of calcification in the central area of the tumor presence of saucer-like defect on the cortical surface of neighbouring bone in some cases, and bending deformity of the affected bone. The incidence and sites of predilection, the main X-ray findings, radiological diagnosis and differential diagnosis of the tumor were discussed.
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PMID:Extraskeletal chondrosarcoma. Report of 8 cases. 128 81

Five cases of primary chondrosarcoma, a rare tumor of the lung, are reported. The diagnosis should be made by pathology. Some conditions should be ruled out: 1. tumor from the chest wall, 2. chondrosarcoma of bone discovered after operation, 3. ovarian teratoma found prior to operation, 4. patient with history of hamartoma of the lung, and 5. atypical pathology. Pathologic subtyping is not prognostic. The main cause of death was intralobar spread. It never gives rise to extrathoracic metastasis and should be treated by surgery.
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PMID:[Primary chondrosarcoma of the lung]. 130 79

The clinical, pathological and radiographic materials of 99 cases with osteosarcoma, fibrosarcoma and chondrosarcoma of the jaws were analyzed comprehensively. Neither obvious differences of age, sex, duration, location of tumor, clinical symptoms and five-year survivals nor radiographic characteristics were found between these three types of sarcoma. The tumor stage and destruction of cortical bone by the tumor are the important factors influencing the prognosis of the patients. The radiographic findings are valuable for the estimation of prognosis.
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PMID:[A comprehensive analysis of osteosarcoma, fibrosarcoma and chondrosarcoma of the jaws]. 130 56

Eleven pediatric brain tumors were studied for the histone H3, Vimentin and MYC gene expression. H3, an S phase cell cycle-related gene (ccr), was found prevalently expressed in tumors with a high mitotic index (MI). Vimentin gene, which contributes to maintaining the cell structure but is also demonstrated to be an early responder gene to growth stimulation was found variously expressed. The different expression of Vimentin gene in the examined samples suggests the active proliferation of the tumor cells. Analysis of MYC gene expression was found increased only in a mesenchymal chondrosarcoma while in other samples MYC mRNA was undetectable. Medulloblastoma, chondrosarcoma, and choroid plexus carcinoma have high S phase H3 gene expression associated with a high MI. Differently an astrocytoma shows a low MI associated with high H3 gene expression. This first preliminary report of H3, Vimentin and MYC gene expression in brain tumors demonstrates that malignant cells are characterized by a different gene expression and different growth potentials.
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PMID:Expression of histone H3 cell cycle-related gene, vimentin and MYC genes in pediatric brain tumors. A preliminary analysis showing the different malignant cell growth potential. 131

Reconstruction of the hip joint by a saddle prosthesis after excision of a malignant pelvic tumor is a relatively new method, which thus far has been mainly used for revision of infected hip arthroplasties. One patient with a metastatic cystosarcoma phyllodes and one patient with a chondrosarcoma of the pelvis were treated by local resection and reconstruction with a saddle prosthesis. Although the patient with the metastatic cystosarcoma phyllodes died 9 months after surgery due to metastatic disease, both patients had early recovery, with no difference in leg length and obtained early painless complete weight bearing with satisfactory functional result. These two case reports clearly illustrate the usefulness of the saddle prostheses in limb saving surgery for malignant tumors of the pelvis.
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PMID:The use of the saddle prosthesis for reconstruction of the hip joint after tumor resection of the pelvis. 132 79

We describe an unusual soft tissue tumor occurring within the rectus femoris muscle of a 64-year-old woman. The site, size, macroscopic, and histological appearances were all consistent with an extraskeletal myxoid chondrosarcoma. However, the present case differs significantly from previous reports of this uncommon tumor in that electron microscopy did not show any evidence of chondroblastic differentiation. Furthermore, the cells failed to stain for vimentin while labeling intensely for neuron-specific enolase, contained large numbers of cytolysosomes having a multivesicular appearance, and focally produced an external lamina. Based on the typical histological appearances we conclude that this is an unusual variant of extraskeletal myxoid chondrosarcoma in which there is evidence of nerve sheath differentiation.
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PMID:Unusual extraskeletal myxoid chondrosarcoma. 137 11

A human fibrosarcoma cell line, HT-1080, and four new cell lines (HS-16, HS-28, HS-30, and HS-42) were established from untreated patients with mesenchymal chondrosarcoma, peripheral nerve sheath sarcoma, malignant hemangiopericytoma, and mixed mesodermal tumor, respectively, and were used for analysis of mechanisms of intrinsic resistance to methotrexate. All four new cell lines were resistant to methotrexate as determined by inhibition of thymidylate synthase in whole cells and by growth inhibition, as compared with HT-1080, a methotrexate sensitive cell line. Methotrexate uptake, level of dihydrofolate reductase, and inhibition of this enzyme by methotrexate in the four cell lines were comparable to HT-1080 cells. However, levels of long chain polyglutamates (glu3-5) of methotrexate achieved after a 24-h incubation with this drug were much lower in the four new cell lines as compared to the HT-1080 cell line (5- to 20-fold lower). The low levels of methotrexate polyglutamates formed is likely the major cause of intrinsic methotrexate resistance in these new sarcoma cell lines.
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PMID:Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. 137 1


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