Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analysis of 374 cases of enchondroma, 42% of which were localized in the short bones of the hand. The findings in radiology and pathology are presented and discussed, with special attention to the difficulty of classifying these tumors histologically and distinguishing them from chondrosarcoma. The recurrence rate in the short bones of the hand was 9%, and 19% in the long tubular bones. It was especially high after mere currettage of the tumor.
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PMID:[Enchondroma - radiology and pathology (author's transl)]. 50 34

The authors report twenty five cases of dedifferentiated chondrosarcoma, illustrating the principal clinical, radiographic and histological features. The prognosis is particularly grave in this neoplasm: the only correct therapy is radical removal of the tumour by amputation or disarticulation.
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PMID:Dedifferentiated chondrosarcomas. 55 17

A primary meningeal mesenchymal chondrosarcoma initially resembled an angioblastic meningioma because the typical chondroid islands were not demonstrable. Cartilage was seen only in an intracerebral recurrence and in subsequent extracranial metastases. Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material. Features of meningeal or pericytic cells were not seen.
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PMID:Primary meningeal mesenchymal chondrosarcoma. 58 58

Chondrosarcomas of the sternum are best treated by resection with tumor-free margins. Reconstruction of the manubrium and superior aspect of the sternum is one of the most difficult challenges for the reconstructive surgeon. In the past, most of the structural stability following resection of this area has depended on the formation of dense fibrous tissue and scar. We presented a case of reconstruction of the bony defect with autogenous bone grafting in conjunction with transposition of the pectoralis major muscle for increased protection and stability of the chest wall as well as for nourishment for the bone graft.
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PMID:Chondrosarcoma of the manubrium. Resection and reconstruction with pectoralis major muscle. 62 45

Sixteen cases of primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog were reviewed from the files of the Armed Forces Institute of Pathology (AFIP). The mean age of affected dogs was 9.5 years. The presenting clinical signs were epistaxis, nasal discharge or facial swelling. Eleven of the affected dogs were purebred. Three of these were Collies and two German Shepherds. The nasal cavity was involved most often. All neoplasms were malignant (11 carcinomas and five sarcomas), and there was invasion of the adjacent bony structures in most dogs. Tumors were classified according to prominent cell type and degree of differentiation into respiratory epithelial carcinoma (four), adenocarcinoma (one), squamous cell carcinoma (one), mucoepidermoid carcinoma (two), undifferentiated carcinoma (three), chondrosarcoma (three) and undifferentiated sarcoma (two).
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PMID:Primary neoplasms of the nasal cavity, paranasal sinuses and nasopharynx in the dog. A report of 16 cases from the files of the AFIP. 62 66

A dural mesenchymal chondrosarcoma is reported in a 19-year-old man. This tumor had features of angioblastic meningioma (meningeal hemangiopericytoma), by light microscopy. However, ultrastructurally this tumor could be distinguished from angioblastic meningioma, and its similarity to extracranial mesenchymal chondrosarcoma was confirmed.
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PMID:Dural mesenchymal chondrosarcoma. Case report. 64 61

The onset of metastatic chondrosarcoma in a young woman was heralded by the appearance of multiple firm, tender, cutaneous nodules two years after the primary tumor in the left scapula had been resected. Chondrosarcoma rarely metastasizes to the skin, but when it does, it may have an identical histological appearance to a cartilaginous tumor of the skin, an entity that is generally considered clinically benign. Although it is very unlikely that an occult chondrosarcoma will be first manifested clinically by a solitary cutaneous metastasis, the abrupt appearance of multiple cutaneous cartilaginous lesions would seem to warrant an investigation for primary chondrosarcoma.
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PMID:Multiple cutaneous metastases of a scapular chondrosarcoma. 64 73

Administration of hematoporphyrin derivative i.v. followed by local exposure to red light has resulted in complete or partial response in 111 of 113 cutaneous or s.c. malignant lesions. Tumors treated have included carcinomas of the breast, colon, prostate, squamous cell, basal cell, and endometrium; malignant melanoma; mycosis fungoides; chondrosarcoma; and angiosarcoma. No type has been found to be unresponsive. In several cases complete clearing of chest wall metastatis has been achieved in treated areas. Deep-seated and pigmented tumors required a higher dose of drug for effective treatment than did the more superficial and nonpigmented lesions. A high therapeutic ratio between tumor and skin response has been obtained by allowing at least 3 days between drug injection and exposure to the therapeutic light for 2,5-mg/kg doses and at least a 4-day interval for 5.0-mg/kg doses.
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PMID:Photoradiation therapy for the treatment of malignant tumors. 66 56

Two relapses of ectopic chondrosarcoma of rare localization were registered at early periods in a 5-month child after surgical operation. Complete regression of the tumor was observed after the 1st course of combined therapy with karminomycin, vincristin and cyclophosphan. Subsequent observations for 2 years showed that the child was practically healthy.
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PMID:[Case of the successful use of carminomycin in combination with cyclophosphane and vincristine in treating ectopic chondrosarcoma of rare localization in a 5-month-old infant]. 67 54

After excision of the hemipelvis through a combined subnatal and anterior incision preserving the lower extremity, five patients with periacetabular chondrosarcoma, after a follow-up of three to six years, were able to walk with no support or with minimum lateral support and had resumed their preoperative occupations. None had either the instability that might have been anticipated or incapacitating discomfort from the neoarthrosis, and there was no evidence of spread or recurrence of tumor in any of the five patients. The procedure, which has the same basic indications as a hindquarter amputation, is a rewarding substitute for that mutilating operation, although the follow-up is too short and the series is too small to warrant conclusions as to the cure rate.
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PMID:Partial or complete resection of the hemipelvis. An alternative to hindquarter amputation for periacetabular chondrosarcoma of the pelvis. 70 7


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