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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case is reported of a patient with pulmonary metastases from a renal adenocarcinoma who experienced subjective improvement and objective tumor regression on Bacillus Calmette-Guerin (BCG) and megestrol acetate therapy. In a subsequent Phase II trial, no objective responses were noted among 15 patients treated with megestrol acetate (160 mg/day X 56 days) and BCG (five immunizing doses intradermally, every 2 weeks X 5). It is concluded that this treatment regimen is not clinically useful in patients with metastatic renal adenocarcinoma.
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PMID:The phase II evaluation of Bacillus Calmette-Guerin plus megestrol acetate in patients with metastatic renal adenocarcinoma. 61 10

Bilateral renal cell carcinoma was diagnosed simultaneously in 6 patients and sequentially in 4 patients, 3 to 14 years after the first tumor had been removed by nephrectomy. Four patients treated conservatively with incomplete excision of the malignant disease are alive 18 months to 14 years after diagnosis. Oue experience suggests that a radical excision, requiring renal dialysis or transplantation, is seldom warranted.
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PMID:Bilateral renal cell carcinoma. 62 5

Five patients with renal cell carcinoma were noted at angiography to have vascular hepatic lesions which resembled metastatic renal cell carcinoma but which proved to be benign hepatic hemangiomas. The angiographic differentiation between small hemangiomas and metastatic vascular neoplasms of the liver can be difficult; angiographic characteristics may not be definitive. Surgery to remove the renal tumor should not be deferred solely on the basis of vascular hepatic lesions found at angiography.
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PMID:Hemangiomas of the liver in patients with renal cell carcinoma. 62 88

A male patient with clinical and pathologic features of blue rubber bleb nevus syndrome is described. Multiple hemangiomata were disseminated throughout the skin and gastrointestinal tract, and typical findings of B cell chronic lymphocytic leukemia and renal cell carcinoma were evident. This case demonstrates a unique instance of associated neoplasia in blue rubber bleb nevus syndrome.
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PMID:Association of blue rubber bleb nevus syndrome with chronic lymphocytic leukemia and hypernephroma. 62 29

Forty-four cases of metastatic renal adenocarcinoma to the lung were studied to assess the efficacy of surgical management and to review the histological criteria for diagnosis. Our data support the role of surgical resection in patients with unilateral pulmonary metastasis. Adverse prognostic features include radiographically multiple lesions and involvement of tracheobronchial lymph nodes. A better survival was associated with extensive tumor necrosis. In patients presenting initially with pulmonary metastases, nephrectomy is indicated only when the metastases are unilateral. The various histological patterns of the neoplasm, and features helpful in differential diagnosis are discussed. An intravenous pyelogram (IVP) is indicated for all patients presenting with clear cell tumors of the lung. In certain cases a renal arteriogram may be necessary to exclude the possibility of a renal primary.
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PMID:Pulmonary resection for metastatic renal adenocarcinoma: pathologic findings and therapeutic value. 63 May 46

A goat antibody against human renal-cell carcinoma reacted on immunofluorescence with renal-cell carcinomas from 20 patients, but not with normal adult human tissues, including kidney. After i.v. administration the I-131-linked antibody showed preferential tumor localization in six of seven patients with primary renal carcinoma. Labeled antitumor antibodies may have the specificity for tumor imaging that current radiopharmaceuticals lack.
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PMID:Radionuclide imaging of primary renal-cell carcinoma by I-131-labeled antitumor antibody. 63 34

One hundred and thirty-eight adenocarcinomas of human kidney were assessed histologically with special reference to the tumor malignancy as indicated by the 5-year survival of the patients. Four different grading systems were used; the classification based on the histologic type of tumor growth, the grading of malignancy according to Arner et al., the grading based on the nuclear structure of carcinoma cells and finally a combined grading system based on the nuclear structure and the demarcation of the tumor from the surround tissue. The histologic type of growth was observed to be an inappropriate basis for grading of renal carcinoma. The grading system of Arner et al. was an appropriate method of malignancy grading despite its somewhat low reproducibility. The grading system based on the nuclear structure of the tumor cells was an accurate measure of the intrinsic malignancy of renal carcinoma and gave an excellent correlation between tumor grade and the 5-year survival rate of the patients. The combined grading system was an equally accurate method in estimating the 5-year prognosis of ranal carcinomas and indicated that the poor demarcation of the tumor from the surroundings in an unfavorable prognostic sign.
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PMID:Grading of human renal adenocarcinoma. 63 86

Twenty-two consecutive cases of renal adenocarcinoma were graded histologically according to the nuclear structure of the tumor cells. The ultrastructural characteristics of these tumors were then evaluated and the findings were compared with the results of the nuclear grading. No ultrastructural characteristic was found which would have been specific for either Grade I, II, III or IV carcinomas. There was no ultrastructural features that could have been used as a basis for malignancy grading. The results show that electron microscopy has nothing to add to the nuclear grading system of renal adenocarcinoma and the value of this grading system is to be emphasized.
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PMID:Ultrastructural characteristics of human renal cell carcinoma in relation to the light microscopic grading. 63 87

In the group of 111 patients treated for hypernephroma, 24 have shown in addition to their usual symptoms a more systolic an elevated blood pressure up to 22 mm Hg and higher. In two cases was hypertension the only symptom. In the hypertensive group, 20 patients underwent nephrectomy and blood pressure returned to normal in all but one. Four pathophysiologic mechanisms of blood pressure elevation in hypernephroma are discussed: (1) AV shunts; (2) Compression of the renal artery or its branches due to tumor expansion; (3) Polycythemia; (4) Hypernephroma with hormonal activity. The hypertension of 6 of our patients was due to AV shunts, of 7, to renal vessels compression, and of 6 others, to a polycythemia.
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PMID:[Hypernephroma as a cause of high blood pressure (author's transl)]. 63 20

On immunofluorescence assay, goat antisera reacted with renal-cell carcinomas from 20 patients, but not with adult normal human tissues (including patient's normal kidney). After in travenous injection, the 131I-labeled antibody localized preferentially in metastatic renal carcinoma in 6 consecutive patients. Labeled antitumor antibodies may have the specificity for tumor imagining which current radiopharmaceuticals lack.
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PMID:Radionuclide imaging of metastases from renal-cell carcinoma by 131I-labeled antitumor antibody. 63 25


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