Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pelvicalyceal echo complex has a characteristic appearance as an echo-filled cylinder in which minimal sonolucency may normally be seen. Alteration in the pelvicalyceal echo complex is a helpful guide in the diagnosis of a variety of pathological processes involving the kidneys. Reliable diagnosis of moderate and marked hydronephrosis may be made by the appearance of uniformly sized, sonolucent collections in the pelvicalyceal echo complex which show communication with the renal pelvis. An adjacent simple renal cyst produces a sharply defined crescent shaped deformity of the pelvicalyceal echo complex, and scalloping is seen with multiple impinging renal cysts. Gross deformity of the central echo complex is seen with polycystic kidney disease, as well as in neoplasia. Edema and infiltrating hypernephroma may result in diminution of the pelvicalyceal echo complex. Amputation or a "V"-shaped splitting of the pelvicalyceal echo complex may be seen with neoplasia.
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PMID:The ultrasonic characteristics of the renal pelvicalyceal echo complex. 41 64

Five cases of extension of renal carcinoma into the inferior vena cava were detected using gray scale ultrasonography. Two different ultrasonographic appearances reflecting the intracaval tumor were observed. Four patients had one or two intraluminal echogenic nodules or thrombi, and the fifth case manifested generalized caval dilatation with innumerable diffuse low amplitude echoes emanating from the lumen. The role of ultrasonography in the complete evaluation of the patient with renal carcinoma is discussed, and the ultrasonographic features of intracaval tumor are demonstrated.
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PMID:Ultrasonic detection of renal tumor extension into the inferior vena cava. 41 44

Adenosine deaminase (ADA) activity was studied in tumor tissue, spleen, and bone marrow of animals bearing a transplantable murine renal carcinoma. Tumor tissue and splenic ADA specific activities were elevated in these animals when compared to controls although splenic specific activity subsequently declined with increasing tumor burden. Marrow ADA specific activity was the same in tumor bearing animals as in controls regardless of variations in tumor size. Studies of this enzyme may offer insight into salvage pathways of purine biosynthesis thereby suggesting exploitable targets for chemotherapy.
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PMID:Adenosine deaminase activity in a transplantable murine renal adenocarcinoma. 42 36

The clinicopathologic features of a case of fibroxanthosarcoma of the kidney are reported. This case represents the third reported case in the literature. The nine-year disease-free survival following nephrectomy in this case suggests that this tumor may have a prognosis different from that of the renal cell adenocarcinoma and that reporting of additional cases should be encouraged.
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PMID:Fibroxanthosarcoma of kidney. 43 59

A review of 890 cases of renal carcinoma in patients admitted to M. D. Anderson Hospital and Tumor Institute from 1975 to 1976 has revealed a significant increase in the proportion of patients in the age group forty to forty-nine years.
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PMID:Changing patterns in age distribution of renal carcinoma patients. 44 14

Renal oncocytoma is a rare tumor of probable proximal tubular origin characterized by uniform cells with abundant, granular, brightly eosinophilic cytoplasm containing numerous mitochondria. The tumor is benign clinically and can be distinguished from renal cell carcinoma.
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PMID:Renal oncocytoma. 44 26

Arteriovenous fistulas commonly occur in cases of renal cell carcinoma, but they rarely produce sufficient left-to-right shunting to cause decompensation of the cardiovascular system. A case of refractory hypertension and congestive heart failure secondary to arteriovenous shunting in bilateral renal cell carcinoma is presented. Renal blood flow studies at the time of staged nephrectomy, together with measurements of cardiac output, established parenchymal arteriovenous shunting as the cause of the patient's cardiovascular symptoms. Subsequent nephrectomy achieved a marked clinical and symptomatic improvement. The causes, diagnosis, and treatment of arteriovenous fistulas are discussed. Although nephrectomy offers dramatic resolution of clinical symptoms, long-term survival depends on the behavior of the neoplasm.
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PMID:Renal arteriovenous fistulas secondary to bilateral renal cell carcinoma. 44 78

Erythropoietin was measured by exhypoxic polycythemic mouse method in the course of a 64-yr-old male with renal cell carcinoma associated with erythrocytosis. Serum erythropoietin fluctuated with progression of the disease. Preoperative elevated erythropoietin (0.11 U/ml, p greater than 0.05) subsided after nephrectomy and again increased with developing lung metastasis (0.1 U/ml, p greater than 0.02). Erythropoietin was markedly increased in the tumorous extracts from primary renal cell carcinoma in the kidney (0.2 U/g, p greater than 0.01) and lung metastasis (0.8 U/g, p greater than 0.01). Renal cell carcinoma from the lung metastasis was transplanted into nude mice, resulting in erythrocytosis in some of these mic. In the erythrocytotic mice, erythropoietin was elevated to levels of 0.25--0.9 U/g (p greater than 0.01) in the tumorous extracts and increased (0.67 U/ml, p greater than 0.02) in the serum. These results indicate that this renal cell carcinoma is an erythropoietin-producing tumor, and this tumor has been successfully transplanted in nude mice for the first time.
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PMID:Erythropoietin levels in the course of a patient with erythropoietin-producing renal cell carcinoma and transplantation of this tumor in nude mice. 44 69

The estrogen-induced hamster renal carcinoma contains appreciable amounts of all cytosolic steroid receptor classes sedimenting as 7 to 8S moieties following sucrose gradient centrifugation. Their relative concentrations, expressed in fmol/mg protein +/- S.E. are progesterone (1496 +/- 23) greater than estradiol (218 +/- 3) greater than 5 alpha-dihydrotestosterone (154 +/- 7) greater than dexamethasone (138 +/- 3) greater than aldosterone (40 +/- 2). No cross-competition is apparent for either estrogen or progesterone receptors, but progesterone competes for both androgen and adrenocorticoid binding. These hormone-receptor complexes undergo nuclear translocation using purified tumor nuclei and in tissue minces at elevated temperatures. Salt-extractable nuclear receptors for estrogen (5S), androgen (3.2S), progesterone (2.7S), and corticosteroid (3.5S) have been identified. The existence of five specific steroid receptors within a single tissue is unique and provides a novel model for studying the interrelated actions of all steroid hormones and their therapeutic responses in a hormone-dependent neoplasm.
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PMID:Nuclear retention of all steroid hormone receptor classes in the hamster renal carcinoma. 44 67

Carcinogenicity of phenacetin was tested using Sprague-Dawley rats. Two groups of animals containing 50 males and 50 females per group were fed respectively with 2.5% and 1.25% phenacetin diet for 18 months and fed thereafter with basal diet for 6 months. Control animals containing 65 males and 65 females were fed with basal diet for 24 months. Animals surviving more than 24 months were regarded as effective animals and killed. Rats that died of tumor development within 24 months were also regarded effective animals. Every organ from the killed and dead animals was fixed in 10% formaldehyde solution and examined histopathologically. Effective number of rats was 27 males and 27 females in 2.5% phenacetin feeding group, and 22 males and 25 females in 1.25% phenacetin feeding group. In control group, 19 males and 25 females were effective. Neoplasms including spontaneous tumors were detected in 26 out of 27 males (96.3%) and 21 out of 27 females (77.8%) of 2.5% phenacetin feeding group, and in 20 out of 22 males (90.9%) and 19 out of 25 females (76.0%) of 1.25% phenacetin feeding group. In control group, 1 out of 19 males (5.3%) and 6 out of 25 females (24.0%) showed spontaneous tumor development. Histopathologically, carcinomas of the nasal cavity, such as adenocarcinoma, squamous cell carcinoma, and transitional cell carcinoma, and the urinary passage, as renal cell carcinoma of the kidney pelvis, and transitional cell carcinoma of the urinary bladder, were most conspicuous, suggesting the target organs of phenacetin carcinogenesis. Males showed higher tumor incidence compared to females. The higher the concentration of phenacetin given, higher incidence of tumors was observed.
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PMID:Tumors of Sprague-Dawley rats induced by long-term feeding of phenacetin. 44 75


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