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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors report their experience of a rare tumor of kidney : oncocytoma. This tumor was made of polygonal cells separated by an endocrinoid stroma. They report pathological feature and clinical course and pronostic who is better than in carcinoma. Other names have been given : proximal tubular adenomas, true kidney hypernephroma, Riopelle tumor.
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PMID:[Renal oncocytomas (author's transl)]. 22 99

Cytogenetic analyses were performed on 3 clonal cell lines derived from a human renal cell carcinoma and its lymph node metastasis, two long-term tissue culture cell lines (NC 65-Sp and NC 65-R) and a serially transplantable tumor line growing on nude mice and brought into culture at the fifth animal passage (NC 65-V). Karyotype were established using banding techniques. Most of the marker chromosomes could be identified and were derived by deletion, inversion, translocation, or isochromosome formation of Chromosomes 1, 3, 4, 5, 8, 9, and 17. These markers were different from HeLa markers. NC 65-Sp had a near diploid chromosome number, NC 65-R a hypotetraploid number, and NC 65-V had a bimodal chromosome number, and NC 65-V had a bimodal chromosome number. Three chromosome markers were shared by the three cell lines; NC 65-R and NC 65-V shared an additional set of four markers. Markers specific to each line were also observed; they demonstrated the independent derivation of the lines and eliminated laboratory cross-contamination. Common markers between the lines confirmed their common tumoral origin.
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PMID:Cytogenetic analysis of human renal carcinoma cell lines of common origin (NC 65). 29 78

Three cases of gastrointestinal bleeding caused by secondary renal carcinoma are presented. Hemorrhage occurred secondary to invasion of bowel anatomically related to the primary tumor. Bleeding can best be controlled by excision of tumor and involved intestine. Surgery is justified by the unpredictable prognosis for renal carcinoma with secondary disease.
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PMID:Recurrent renal carcinoma causing intestinal hemorrhage. 30 14

We used delayed hypersensitivity skin testing, in vitro lymphocyte blastogenesis, and lymphocyte surface markers to examine the relationships among host immunologic competence, tumor type, tumor stage, prognosis, and the effects of cancer treatments in patients with genitourinary cancer. We found correlations between host immune competence and both tumor stage and prognosis among patients with bladder cancer, renal cell cancer, and those with advanced prostate cancer not receiving endocrine therapy, but not among patients with prostate cancer receiving endocrine therapy. Radiation and chemotherapy suppressed T-lymphocyte levels, but a chemotherapy-induced tumor remission resulted in a rebound of T-cell counts to above normal levels. In tissue sections of bladder cancers, regions of mononuclear infiltration were virtually devoid of cells with complement receptors or receptors for cytophilic antibody, which suggested that lymphocytes infiltrating bladder cancers are predominantly T-lymphocytes.
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PMID:Host immunocompetence in genitourinary cancer: relation to tumor stage and prognosis. 31 91

Renal cell carcinoma may develop in up to 25% of patients with Lindau-von Hippel disease who survive the earlier manifestations of this disease, and this neoplasm may frequently be bilateral. With early detection of such lesions, operative cure of renal cell carcinoma is more likely in these patients. However, some patients may need to undergo bilateral nephrectomy for cure. Such a patient may benefit from cadaver renal transplant in spite of the increased risk of cancer in immunosuppressed patients. We present such a case in a patient with Lindau-von Hippel disease.
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PMID:Renal transplantation in Lindau-von Hippel Disease. 32 75

Adenosine deaminase (ADA) is a critical enzyme in purine metabolism and lymphocyte ADA activity is specifically related to immunocompetence in man. Since immunologic factors are relevant in patients with renal and transitional cell carcinoma, we studied lymphocyte ADA activity in these patients. In renal adenocarcinoma patients lymphocyte ADA activity was reduced. Such reductions were most marked in low-as compared to high-stage lesions. Nephrectomy resulted in a rise and disease progression in a decline in ADA activity. In contrast, bladder, carcinoma patients showed elevated lymphocyte ADA activity most marked in high-stage lesions. Disease progression was associated with a rise and tumor resection with a decline in lymphocyte ADA activity. Discordance in patterns of lymphocyte ADA activity when patients with renal and transitional cell carcinoma are compared suggests unique host-tumor interactions at the enzyme level. Studies of ADA may offer insight into molecular aspects of immune mechanisms.
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PMID:Studies of lymphocyte adenosine deaminase activity in patients with renal and transitional cell carcinoma. 39 61

Seven patients with multiple myeloma who developed a second neoplasm are presented. There were four patients with acute leukemia and three patients with non-hematologic neoplasms. The patients with acute leukemia were among the longest survivors (median duration approximately 72 months) and the response to anti-leukemic therapy in these patients was generally poor. Of the three patients with non=hematologic neoplasms, one patient was observed with simultaneous renal cell carcinoma and the other two patients developed adenocarcinoma of the colon and lung subsequently. In addition, two patients with mammary carcinoma who subsequently developed multiple myeloma were included. Literature was reviewed and the possibility that multiple myeloma itself might be a risk factor for the development of other malignancies was discussed.
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PMID:Second malignancies in patients with multiple myeloma. 40 42

Sarcomas of the kidney are highly malignant neoplasms. Abnormal vascularity can be detected in almost all types of sarcomas, but arteriovenous shunting, pooling of contrast material, and tumor staining are seldom present. Extension to renal vein and inferior vena cava may occur. While angiographic findings in our seven cases of renal sarcomas were nonspecific, this diagnosis should be considered in a relatively hypovascular neoplasm especially when the capsular arteries contribute considerably to the vascular supply. Nevertheless, statistically the most likely diagnosis of a hypovascular mass is renal cell carcinoma. Angiographic studies do not alter the management of the patient but merely suggest the diagnostic possibility of sarcoma. Angiographic diagnosis of different histologic types of sarcomas is not possible.
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PMID:Sarcoma of the kidney: angiographic features. 40 19

From 1964 to 1974, 1,668 patients with renal carcinoma were seen at the Mayo Clinic. Bone metastases were present in 167 of these patients (only lung metastatic involvement ranked higher in frequency). More than one-third of the patients with bone metastasis from renal carcinoma had this as a presenting lesion of occult renal tumor. This group constituted 4% of all patients with renal carcinoma evaluated during the study period. While most bone lesions were in the pelvis and lower lumbar spine, any bone may be involved. All patients with bone metastases from renal carcinoma have a poor prognosis. However, some bone lesions appeared as long as 10 or more years after the initial tumor. The most common radiographic features are a lytic destructive process with indistinct margins, erosion of the cortex, and frequent expansion into the soft tissues. Pathological features are common in the long bones, and calcifications are occasionally seen. The synovial joints are not affected. A well defined sclerotic margin is a common finding after radiation treatment, although it is not a reliable indicator of the stability of the lesion.
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PMID:Radiographic manifestations of bone metastases from renal carcinoma. 40 45

Since 1967 we have been using preoperative radiation therapy for renal cell carcinoma as proposed by Riches. Radiation therapy, to include the para-aortic lymph nodes, is given in 250-rad increments four times weekly to a total dose of 3,000 rads. After an interval of three weeks following radiation therapy, we performed radical nephrectomy. The object of this preoperative treatment is devitalization of growing cells in the periphery of the tumor, thus preventing metastases and local recurrence, and and decreasing the size of the tumor and thereby facilitating surgery. In one third of the cases there is radiologically demonstrable decrease in the size of the tumor, probably secondary to obliteration of the dilated veins in the capsule. The delay of six weeks has had no adverse effect on the outcome of metastases.
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PMID:Preoperative irradiation of renal cell carcinoma. 41 Dec 7


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