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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fifty examples of a distinctive clinicopathologic entity occurred in 49 patients who ranged in age from 8 to 70 (median 46) years. Forty-nine tumors were on the face, mainly the cheek, chin and forehead; most were present one to five years, and 85% of the patients were female. The growths varied in size from 3 to 8 mm; many were hard and annular, with a raised border and depressed nonulcerated center. Histologically, narrow strands of basaloid cells and epidermoid cyts infiltrated a fibrotic stroma. This tumor, which we have named desmoplastic trichoepithelioma, must be differentiated histologically from morphealike basal cell carcinoma, desmoplastic cutaneous metastasis, and certain benign adnexal neoplasms.
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PMID:Desmoplastic trichoepithelioma. 58 63

Three examples of an unusually aggressive form of basal cell carcinoma in the skin of the scalp were treated surgically. The extent of each tumor was verified with gross and microscopic examination. The tumors invaded fat, muscle, fascia, and bone. Dural involvement was seen in one case. Light microscopy showed a marked variation in growth patterns and cytologic types from one portion of the tumor to another. Characteristics included a diffusely infiltrating pattern with a fibrotic stromal response, rare intraepidermal tumor nests, formation of occasional duct-like structures, poor cellular cohesion with single-life invasion through dermal collagen, perineural invasion, and pleomorphism with varying nuclear cytoplasmic ratios. Basaloid populations with peripheral palisading were seen in each tumor. These malignancies may be representative of an unusual basal cell carcinoma variant unique to the scalp.
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PMID:Aggressive basal cell carcinoma of the scalp. 64 3

Malignant neoplasms in lateral cervical cysts and fistulae have been frequently described in the literature. In the following case, a tumor is reported which was found in the unusual localization of a preauricular fistula. The histologic diagnosis was basal cell carcinoma. In this 41-year-old male patient the tumor led to local recurrent inflammatory symptoms. Therapy consisted first of excision of the fistula. After final diagnosis was made, total parotidectomy and an additional excision of the skin were carried out.
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PMID:[Basal cell carcinoma developing in a preauricular fistula (author's transl)]. 65 83

The presence of contractile proteins in human cancer cells has been studied by means of: a) immunofluorescent staining using specific antibodies, and b) electron microscopy in order to detect the presence of cytoplasmic filaments. The tissues examined were: normal human skin, basal cell carcinoma of the skin, squamous cell carcinomas (of skin, oral cavity, and larynx), normal nonlactating mammary gland, and infiltrating mammary carcinoma with or without fibrosis. Normal tissues were negative after immunnoflurosescent staining of contractile proteins and contained no or minimal amounts of microfilaments as judged by electron microscopy. Tumor cells were strongly positive after immunoflouorescent staining for actin, myosin, light and heavy meromyosin but were negative for tropomyosin. Moreover, they contained prominent microfilaments (40 to 80 A in diameter) with some filaments (100 to 120 A in diameter) scattered in between. It appears that malignant cells contain an increased amount of contractile proteins, organized in the form of a filamentous apparatus, when compared to their normal counterparts. The study of the presence of contractile proteins in tumor cells may be of potential importance in evaluating malignant growth.
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PMID:Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study. 77 90

Whereas basal cell carcinoma usually is a slow-growing tumor of the head and neck region, we have observed, over a 20-year period, three large, unique basal cell tumors of the back that were distinctive and presented clinical and histologic problems in diagnosis. They commonly formed exophytic, vegetative, flesh-colored to red, sessile plaques up to 20 cm in diameter. Ulceration was the principal feature of a fourth tumor, which destroyed the skin of the entire lumbar area and invaded the muscle. Regional-node metastases from this tumor showed basal cell carcinoma. Histologically, all the primary lesions were adenoid basal cell carcinomas with mucinous stroma. Histochemistry in two cases demonstrated minimal respiratory enzymes and no special esterolytic or lysosomal enzymes. Surgery was curative in three of these cases of rare, giant variant of basal cell carcinoma of the skin.
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PMID:Giant basal cell carcinoma. 84 97

Four cases of metastasizing basal cell carcinoma, one occurring in the basal cell nevoid syndrome, are presented. Two patients are surviving without evidence of additional metastases. One patient died from cerebral involvement 31/2 years after a lymph node metastasis was established by aspiration biopsy. One patient died from complications of cerebral palsy one year after a metastasis to a regional lymph node was discovered in the primary resection of the neoplasm. Only 90 cases of metastases from basal cell carcinoma have been reported previously.
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PMID:Metastatic basal cell carcinoma. Report of four cases. 85 Jul 12

A case of a metastasizing basal cell carcinoma that began 24 years earlier as a rodent ulcer on the back is reported. Histologically there were strands of characteristic basal cell type cells and, in addition, areas of squamous cell differentiation. The problem of "epithelioma metatypique" is discussed. The autopsy showed pure basal cell metastases in the lungs, the paraaortal lymph nodes and penetration of the tumor masses into the vena cava inferior. The unsufficient treatment by X-ray seems to be a conditioning factor by injuring the surrounding stroma.
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PMID:[Metastizing basalioma. A case contribution]. 87 96

Two cases of basal cell carcinoma had diffused infiltration that included not only perineural but endoneurial invasion. One patient presented with trigeminal neuralgia, and the other patient developed localized neuralgia when the tumor recurred. Nests and indian files of carcinoma cells were in the endoneurium, a region that anatomically is devoid of lymphatics. The involved nerves displayed axonal degeneration. Such intraneural invasion by basal cell carcinoma is very rare, even in the scelerosing variety of basal cell carcinoma.
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PMID:Basal cell carcinoma with intraneural invasion. 92 62

A report is given on the formation of a basal cell carcinoma (Basalioma solidum) on a tubed pedicle flap of acromiopectoral transplanted into the oral cavity. This plastic successfully covered a vast perforation of the palate after a severe wounding by shell splinters 33 years ago. The histologically proofed basal cell carcinoma (Basalioma solidum) was entirely brought to disappearance by 6000 R tumor-dose telecobalt. After 1 1/2 years the patient was without any complaint and recurrence. Etiology and pathogenesis of basal cell carcinoma (Basalioma solidum) are discussed in the light of the literature.
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PMID:[Basal cell carcinoma (basalioma solidum) on a tubed pedicle flap in the oral cavity (author's transl)]. 97 Oct 48

Eight patients had plantar growths that were usually irregularly shaped, sharply outlined, verrucous, and several centimeters in greatest dimension. Clinical diagnoses included viral wart, deep mycosis, pyogenic granuloma, amelanotic melanoma, basal cell carcinoma, and eccrine poroma. The median age of the patients, and duration of the growth, were 52 and 16 years, respectively. Therapeutic modalities other than total excision were ineffective. The tumor, derived from surface epidermis, was composed of masses of pale-staining benign-appearing prickle cells, deeply invaginated by thick, compact, partially parakeratotic horn. Several lesions have recurred; amputation was required in one patient. This distinctive entity, apparently not described in the American literature, has been reported from Europe under such titles as epithelioma cuniculatum and papillomatosis cutis carcinoides. We believe that it is best interpreted as a form of verrucous carcinoma, the first cutaneous tumor--as opposed to lesions of mucous membranes and mucocutaneous junctions--to be so classified.
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PMID:Verrucous carcinoma of skin: epithelioma cuniculatum plantare. 99 Oct 89


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