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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An unusual case of basal cell carcinoma of the nipple from a 66-year-old women is presented. It is important to differentiate this lesion from other nipple-areolar tumors, especially Paget's disease. This report reviews the literature and adds a case that represents the third reported instance of this tumor of the female nipple.
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PMID:Basal cell carcinoma of the nipple: case report and review of the literature. 33 29

Twenty-eight cervicovaginal tracts from approximately 2-year-old female BALB/cCrgl mice neonatally exposed to ovarian steroids were cut into small segments and transplanted into syngeneic hosts. Within six months, six of 28 host animals developed tumors. Three tumors were from progesterone-exposed mice, two were from estrogen-exposed mice, and one was from estrogen-progesterone-exposed mice. These tumors have been maintained by serial transplantation for approximately two years. The progesterone-induced tumors are mixed tumors with both squamous cell and glandular components. The estrogen-induced tumors are squamous cell carcinomas. The estrogen-progesterone-induced tumor was originally a squamous cell carcinoma, which now resembles a basal cell carcinoma. The other tumors have maintained their original morphological characteristics. All tumors have proven to be hormone independent. No control cervicovaginal tracts developed tumors after transplantation, even after 24 months in the host animals.
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PMID:Transplantability and sex steroid hormone responsiveness of cervicovaginal tumors derived from female BALB/cCrgl mice neonatally treated with ovarian steroids. 44 60

Human basal cell carcinomas, obtained from 10 subjects were transplanted to 25 "nude" mice. Two methods of transplantation were used and compared. Grafting gave better results than subcutaneous implantation. Tumor cells were identified in 5 mice, however only 2 of them developed lesions with histology similar to human basal cell carcinoma. Grafts, in which tumors developed, were obtained from superficial basal cell carcinoma. No reasons for the cause of the low percentage of successful transplantation and slow rates of growth of the transplants are found; however, possible immunological, vascular and environmental factors are discussed.
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PMID:Heterotransplantation of human basal cell carcinomas in "nude" mice. 44 64

Two groups of patients, 37 with primary basal cell carcinoma of the eyelid and 16 with basal cell carcinoma of the eyelid previously treated by other physicians were reviewed. All of the tumors were excised with at least 3 to 4 mm of normal-appearing tissue at each margin of resection. All of the excised specimens were submitted for frozen section studies of the margins. A total of 20 (54.04%) of the previously untreated tumors and eight of the previously treated tumors had at least one margin involved with tumor cells. Repeated excisions under frozen section control were done until all of the margins were free of tumor cells. To date, none of the patients treated in this manner had a recurrence of the tumor.
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PMID:Frozen section control in the surgery of basal cell carcinoma of the eyelid. 45 10

Delayed radiation necrosis of the brain was found around the right ear in a patient with basal cell carcinoma of the skin. Five months after excision, the tumor recurred. The patient received 5,575 rads in 24 doses during radiotherapy. Thirteen months later, the patient had cerebral radionecrosis, which was the cause of death. At autopsy, typical radionecrotic lesions of the temporal lobe were found. There were widespread metastases.
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PMID:Delayed cerebral radionecrosis following treatment of basal cell carcinoma. 45 39

The number of tumor-infiltrating macrophages was estimated in 43 patients with skin cancer, including 18 cases of squamous cell and 25 cases of basal cell carcinoma. Macrophages were identified in cell cultures by 2 assays, namely phagocytosis and resistance to detachment by trypsin. The average percentage of adherent cells for the 2 groups of skin tumors was 4.5 +/- 2.6 and 10.2 +/- 5.2, respectively, and the difference was statistically significant. Follow-up studies after surgical excision of the primary neoplasm showed a relatively low macrophage content in 2 of the 4 cases in which local recurrences occurred. Preliminary functional studies suggested that soluble factors may be released by neoplastic cells, accounting for the inhibitory effect of tumor cell supernatants on macrophage chemotaxis in vitro.
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PMID:Macrophages in skin cancer: quantitative and functional studies. 46 81

The nose is one of the most common sites of malignancy on the face, probably because of its unique position of exposure to environmental damage. By far the most common type of nasal tumor is basal cell carcinoma. Squamous cell carcinoma is less common but considerably more aggressive, with a tendency to fast growth and metastasis. Tumors of either type are more likely to invade easily and resist treatment if they are in certain "danger zones." Nasal skin cancer in general has a relatively good prognosis, regardless of the type of treatment selected, ie, surgery, radiotherapy, cryotherapy, or electrodesiccation and curretage. However, tumors that are not eradicated have a long history of recurrences before proving fatal. When ablative surgery is performed, some type of reconstructive procedure is usually necessary.
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PMID:Nasal skin cancer:hazard to a uniquely exposed structure. 47 45

Light microscopic examination of a basalioma (basal cell carcinoma) revealed unusual keratinizing cells resembling signet ring cells with pink cytoplasmic inclusions. Ultrastructurally the inclusions consisted of filamentous masses encircled by abundant tonofilaments giving a striking picture of abnormal individual tumor cell keratinization.
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PMID:Basal cell carcinoma--signet ring type. Ultrastructural study. 47 28

A total of 97 cases of metastatic basal cell carcinoma have been reported in the literature, 22 of which were metastatic to bone. To date there has been no survival following bone metastasis. A case report of significant long-term survival--over three times the expected--is presented. The treatment described is perhaps a guideline for management of basal cell carcinoma metastatic to bone, though it is presumed the basic biological nature of the tumor determines length and quality of survival.
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PMID:Long-term survival in basal cell carcinoma metastatic to bone: a case report. 54

As life expectancy increases the diagnosis and treatment of basal cell carcinoma of the lids is assuming ever greater importance. While there is still some debate as to whether conservative or surgical treatment is preferable, the emphasis in conservative treatment varies. Our own view is based on an analysis of 531 surgically treated patients. For histologic differentiation we used the data of Lever (1958). Considering that our recidivity rate was only 6.2%, we recommend primary surgical treatment. After localization of the tumor the inner canthus in particular should be kept under observation for recurrences. Histologic differentiation showed the sclerodermiform basal cell carcinoma to be especially dangerous.
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PMID:[Prognosis of basal cell carcinoma of the eyelids in relation to histologic differentiation and thoroughness of resection]. 55 99


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