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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of basal cell carcinoma and epithelioma in the upper and lower lips are reported. The defects in the upper lip following tumor excision were repaired with an application of Burow's technique. Martin's method, after modification of Bernard cheiloplasty, was used for the repair of the lower lip defect. The methods proved to be quite effective in providing excellent aesthetic results. No disturbance was noted in the activity of the repaired upper lips. The labial function, however, associated with the orbicularis oris was left impaired in the newly formed lower lip.
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PMID:Primary reconstruction of defects in the upper and lower lips following tumor excision. 11 24

A double labeling method with two levels of tritiated thymidine was used to study 6 patients with seborrheic keratosis, 1 with a fibroepithelial tumor of Pinkus, and 1 with basal cell nevus syndrome manifesting three pits on the palm of the hand. The two latter types of lesions, known to be able to evolve into basal cell carcinoma, had an increased S-phase duration (18 hr for the germ cells of the palmar pits) as compared with normal epidermis (10 hr). This situation was similar to that observed in basal cell carcinoma, However, the S phase was not lengthened in seborrheic keratosis (9.2 plus or minus 1.6), a benign tumor in which malignant transformation is extremely rare. S phase was also of normal duration in the benign eosinophilic septa of the tumor of Pinkus.
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PMID:Kinetics of cell proliferation in benigh and premalignant tumors of the human epidermis. 12 65

Comparative ultrastructural studies of basal cell carcinomas, seborrheic keratoses, actinic keratoses, and control nontumor skin from human patients demonstrate structural differences between invasive and noninvasive tumor cells. Compared to the other specimen groups, biopsies of basal cell carcinomas reveal a decrease in hemidesmosomes and an increase in actin-like microfilaments in cells at the margins of the tumors. Benign tumors, i.e., seborrheic keratoses and actinic keratoses, have hemidesmosome areas and microfilament contents resembling control nontumor skin. The most striking hemidesmosome areas and microfilament contents resembling control nontumor skin. The most striking increase in microfilaments is in the most infiltrative "morphea" variants of basal cell carcinoma. These findings, in the context of other published reports, suggest that increased microfilaments are related to enhanced motility of invasive carcinoma cells in vivo and that decreased hemidesmosomes may be related to loss of cell to substratum or "anchorage" dependence of growth in malignant cells.
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PMID:Ultrastructural comparison of the interface between epithelium and stroma in basal cell carcinoma and control human skin. 13 74

Intercellular junctions of various types were found on the membrane fracture faces of human nodular basal cell carcinoma (BCC) cells. The junctional types represented include desmosomes, tight junctions, and gap junctions. A semiquantitative comparison of undifferentiated and differentiated nodular BCC showed that gap and tight junctions were observed on all exposed membrane fracture interfaces of the differentiated tumors, while only fifty six per cent of the membrane interfaces of the undifferentiated tumor exhibited similar junctional specializations. These membrane specializations may be a partial reflection of differentiation among the different types of BCC and their contribution to the less invasive character of nodular BCC cannot be ruled out.
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PMID:Intercellular junctional specializations in human basal cell carcinoma. A freeze-fracture study. 15 45

In two cases of basal cell carcinoma with prominent granular cell features, light microscopic examination showed a tumor with the general configuration of a nodular basal cell carcinoma. Focally, there were masses of cells with eosinophilic, granular cytoplasm and large cytoplasmic inclusions, strongly suggestive of granular cell myoblastoma. Ultrastructural observations in one case showed numerous lysosome-like organelles that were similar to those described for granular cell myoblastoma, but were identical to those described for the granular cell variant of ameloblastoma, a tumor that frequently resembles basal cell carcinoma. Additional features included tonofilaments and desmosomes, both of which support an epithelial origin for the granular cells in this rare variant of basal cell carcinoma.
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PMID:Granular cell basal cell carcinoma. A distinct histopathologic entity. 22 2

Fibroblast cultures derived from human basal cell carcinomas demonstrated an increased capacity to synthesize and secrete collagenase. Although the levels of collagenase were up to 8-fold greater than those of normal control cell lines, this phenotypic trait was not permanent and was expressed only for a few passages following primary explanation. The basal cell carcinoma fibroblast collagenase was secreted as a proenzyme. The kinetics of activation and the catalytic efficiency of the basal cell carcinoma fibroblast enzyme were equal to control collagenase, indicating that increased activity was due to increased synthesis of enzyme protein. Increased synthesis of collagenase was not due either to altered cell growth or to an overall increase in protein synthesis. Furthermore, synthesis of another major protein, of another major protein, collagen, was not enhanced. The data suggest that the tumors may have stimulated adjacent fibroblasts to produce more collagenase which is of importance in tumor invasion.
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PMID:Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas. 22 89

The authors present 8 cases of rare tumors of the nasal septum and define a number of characteristic points on the basis of each of them. The following are presented: --a malignant nevus, the rarety of E.N.T. sites of such tumors is emphasized, as well as important role of immunotherapy in their treatment, alongside surgery and radio-therapy. --a keratoacanthoma, difficult in terms of differential diagnosis from a basal cell carcinoma. -- a cavernous hemangioma, excision of which must be wide if recurrence is to be avoided. --one very hemorrhagic mixed tumor. --one case of pseudo tumoral tuberculosis in a woman with no known past history of tuberculous disease. --one very painful glomus tumor, radical treatment of which is surgical, in preference to radiotherapy. --two cylindromas of the septum, one taking the form of a large, angiomatous polyp, which puts in question the name of cystic adenoid carcinoma, suggested for these non-cutaneous tumors.
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PMID:[Rare tumors of the septum. 8 reported cases (author's transl)]. 23 Jul 77

Many observations support the premise of a close relationship between immunologic competency and the growth of human cancer. Immunotherapy against cancer in animals has been established. Its function appears to be adjunctive to other treatment modalities that first lower tumor burden. These findings are demonstrated in both clinical and laboratory studies of cancer in humans. At the present time, intralesional injections of BCG vaccine in immunocompetent patients with intradermal metastases are most effective. Immunotherapy with topical administration of 2,4 dinitrochlorobenzene is the treatment of choice in selected patients with squamous or basal cell carcinoma.
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PMID:Immunotherapy of malignancy in humans. Current status. 23 2

The authors describe six observations of malignant tumors which had appeared in the region of the irradiation fields after a period of 11 to 51 years following to a radiotherapy. The doses were between approximately 2000 and 9000 R resp. rd. The individual tumors were: one osteogenic sarcoma, one chondrosarcoma, two fibrosarcomas, one lymphangio-hemangio-sarcoma and one basal cell carcinoma. According to the present state of our knowledge about the induction of tumors by ionizing radiation, we presume that no threshold dose does exist and that the danger of a tumor induction increases with the dose. The function of the tumor induction is still in general discussion.
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PMID:[Contribution to the discussion about the induction of tumors by ionizing radiation (author's transl)]. 26 98

In 93 reported cases of metastatic basal cell carcinoma (BCC), 76 had spread through lymphatics or blood vessels. Two more cases are presented, bringing the total to 78. Metastasis to regional lymph nodes was the most frequent, followed in frequency by lungs, bones, and other organs. The size of the primary tumor, its site, its resistance to x-ray therapy, and the effects of radiation appeared to contribute to the occurrence of metastasis. However, in an appreciable number of cases, tumor dissemination was related to incomplete excision followed by immediate wound closure, particularly by grafting. It is recommended that wound grafting be delayed for at least six months after excision or large or recurrent BCC in order to assure complete removal.
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PMID:Metastatic basal cell carcinoma: review, pathogenesis, and report of two cases. 33 91


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