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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of a series of 97 invasive carcinomas of the cervix, 5 were found to have argyrophil tumor cells, and 3 of these 5 tumors were studied by electron microscopy. The ages of the 5 patients ranged from 36 to 49 years, with a mean age of 42.4 years. The morphologic features of these five tumors were well consistent with those described on a variety of endocrine polypeptide neoplasms such as thyroid medullary carcinomas, carcinoids, pancreatic islet-cell tumors, and oat cell carcinomas of the lung. Microscopically, the 5 tumors were characterized by the formation of solid-sheets, ribbons, streams, and rosettes. They were characterized electron microscopically by the presence of neurosecretory-type granules, the abundance of intracytoplasmic microfilaments, the absence of tonofibrils, and the paucity of desmosomal attachments. On the basis of the microscopic, electron microscopic and cytochemical characteristics, it is suggested that the tumors are a specific type of cervical carcinoma derived from the argyrophil cells, normally found among the linings of the endocervical glands and the cervical squamous epithelium. We believe these 5 tumors should be regarded as an endocrine tumor, another member of apudomas.
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PMID:Argyrophil cell carcinomas (apudomas) of the uterine cervix. Light and electron microscopic observations of 5 cases. 5 Jun 65

Fifty-five patients treated for cervical carcinoma developed bony metastases between January 1, 1961 and December 31, 1973. Roentgenograms were diagnostic in all but 2 of the patients. In 15 patients, a combination of radioactive scans and roentgenograms was used to establish the diagnosis. The most common mechanism of bony involvement from carcinoma of the cervix was extension of the neoplasm from para-aortic nodes, with involvement of the adjacent vertebral bodies. The earliest metastases were discovered at the time of the primary diagnosis. Thirteen years was the longest interval from the primary diagnosis until the discovery of bony metastases. Sixty-nine percent of the patients were diagnosed within 30 months. Ninety-six percent of the patients died within 18 months. Seventy-six percent of the patients received some form of therapy for their metastases. Thirty-six of these patients were treated with radiation therapy. Four of these patients received complete relief of symptoms, 24 some relief, and 8 patients received no relief.
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PMID:Bony metastases from carcinoma of cervix. Occurrence, diagnosis, and treatment. 5 Aug 73

The nuclear DNA content of cells from 20 cases of mammary aspirates was estimated by microspectrophotometry. Smears stained according to Papanicolaou were destained and Feulgen-reacted. Among the smears there were 14 with doubtless tumor cells, four with a benign cell picture, and two of a doubtful nature. The mammary lesions were in all cases verfied by histology. Measurements showed that smears of benign tumors had a diploid or diploid to tetraploid distribution of DNA. The two doubtful smears also showed the same DNA pattern, although in one case the cells were from a papillary carcinoma and in the second case from a fibroadenoma. Malignomas with a cell picture, monomorphous-atypical in Papanicolaou staining exhibited a DNA histogram with a peak in the diploid to hyperdiploid ranges. Carcinomas showing a polymorphous-atypical cell picture were characterized either by polyploid values, by a large spread, or by aneuploidy. Hence, it is impossible to safely distinguish benign cases from carcinomas by the DNA pattern, since DNA distribution is fairly identical in part of the cases in either group.
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PMID:Feulgen-DNA-cytophotometry on mammary tumor cells from aspiration biopsy smears. 5 68

A glycoprotein was isolated from 3M KCl extracts of mammary carcinoma. Addition of an optimal amount of the carcinoma associated glycoprotein induces proliferation of both peripheral blood lymphocytes from normal donors and from patients with mammary carcinoma. RNA-dependent DNA-polymerase levels were found to be markedly increased in glycoprotein-untreated lymphocytes from patients with mammary carcinoma and in glycoprotein-treated lymphocytes of both normal donors and tumor-bearing patients. A factor ("Blocking Factor") was eluted at pH 3.1 from the cell membrane of the mammary carcinoma cells. Addition of an optimal amount of this factor inhibits the glycoprotein induced stimulation of the RNA-dependent DNA-polymerase activity in glycoprotein-treated lymphocytes of both normal donors and tumor-bearing patients.
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PMID:Lymphocyte stimualtion by a mammary carcinoma assoicated glycoprotein. 5 27

Alpha-1-fetoprotein is an example of a circulating, measurable tumor product of diagnostic and therapeutic value. The involvement of its synthesis could be a result of a premalign cellular change in cell biochemistry. Contrary to the synthesis of trophic hormones in certain undifferentiated neoplasms, alpha-1-fetoprotein in hepatoma is specific for the organ origin of the tumor. Unlike the immunoglobulins in myeloma or the corticosteroids in adrenocortical tumors, it is a protein that normally can be synthetized in the fetus only. The purpose of the present paper is to discuss a new method for testing serum samples of blood donors being suspected of an alpha-1-protein by means of counterelectrophoresis. The diagnostic value is shown in a blood donor who could be singled out as a suspect of primary liver carcinoma only by means of serological testing.
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PMID:[Serological identification of carcinospecific antigens (and their significance as donor screening or for specific groups of diseases)]. 5 22

The clinical and pathologic features of 43 primary adenacarcinomas of the small intestine (32 jejunal and 11 ileal) are reported. Seventy-four percent of the patients presented with partial or complete small bowel obstruction, 56% complained of abdominal pain, 37% had symptoms of anemia (weakness, easy fatigability), and 35% had lost weight. Anemic hemoglobin levels occurred in 69%, and a palpable abdominal mass in 25%. Treatment consisted of a "curative" or "palliative" resection, or a bypass procedure. Seventy-nine percent of the tumors showed an annular, constricting pattern, while the remaining 21% had a predominantly fungating or polypoid appearance. Three individuals currently free of clinical recurrence have been followed less than 5 years. Of the remaining 40 patients, a 5-year cure was achieved in 11 (28%), including 6 (15%) who at present have no recurrence and 5 (13%) who subsequently died of other causes. Within 5 years, 28 of these 40 patients (70%) were known or presumed dead tumor, and 1 had succumbed to other causes (2%). Various pathologic features were correlated with the clinical course. Documented lymph node metastasis proved to be the most valuable prognostic finding, 88% of these individuals dying of tumor, as contrasted to 45% of those with tumor-free nodes. A few cases of superficially invasive carcinoma found in an otherwise benign adenomatous lesion had a good prognosis when symptoms were produced mainly by the adenoma, the carcinoma being a relatively minor component.
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PMID:Primary adenocarcinoma of the jejunum and ileum. A clinicopathologic study. 5 95

Distribution of the bleomycin A2 suspended in sesame oil (Oil Bleo Suspension) in rat organs and tumors after the intramuscular administration was investigated by bioassay, the effect of intratumor administration of the suspension on the growth of rat mammary carcinoma induced by 7, 12-dimethylbenz (a) anthracene was also studied. The oil suspension showed a protracted concentration in either tumor or organ tissues, but showed similar inhibitory effects on rat mammary carcinoma to those by regular bleomycin solution. Further studies should be performed on the effect of bleomycin A, in sesami oil on mammary carcinoma.
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PMID:[Distribution of bleomycin in sesame oil suspension in organs of rat with mammary carcinoma induced by 7,12-dimethylbenz (a) anthracene and its effect on the tumors (author's transl)]. 5 98

Single-agent chemotherapy of advanced and recurrent squamous carcinoma of the female genital tract has been largely ineffective. Combination-drug therapy which has augmented the efficacy of chemotherapy in numerous solid and nonsolid human tumors is usually attended by a degree of toxicity that has discouraged its use against malignancies exhibiting a poor response to single agents. A seven-drug regimen consisting of cyclophosphamide, 5-fluorouracil, actinomycin D, vincristine, cytosine arabinoside, methotrexate, and bleomycin administered during a 24 hour period at 4 week intervals was selected for clinical trial against squamous malignancies of the female genitalia because of its proved broad-spectrum activity among solid tumors and its low incidence of serious toxicity. Severe bone marrow depression occurred during only two of 98 drug cycles involving 23 patients. An objective tumor response was observed in nine of 18 evaluable patients. This regimen appears to be useful in the palliative management of squamous carcinoma of the female genital tract.
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PMID:Seven-drug polychemotherapy in the treatment of advanced and recurrent squamous carcinoma of the female genital tract. 5

(1) Passive hemagglutination and radioimmunoassay are suitable methods for the detection of AFP in the low concentration range. (2) In 3.72% of the cases a clinically unknown carcinoma was found in an unselected group of patients with liver cirrhosis. (3) 21.9% of the patients showed AFP elevations up to 2000 ng/ml. In 10.6% of this group, increasing titers demonstrated a primary liver cell carcinoma. In 89.4% a transitory rise of AFP was not associated with tumor growth. Levels return to normal values within three months in 90% of the cases. (4) Transitory AFP elevations are not correlated to clinical conditions (praecoma, coma, delirium, bleeding, ascites, shunt) or to biochemical parameters (GOT, GPT, bilirubin, prothrombin complex time, gamma-globulin). (5) A temporary rise in AFP is more frequently observed in groups with high hepatoma incidence than in groups with low hepatoma incidence. (6) Therefore, it may be suggested that a transitory rise of AFP could reflect a "primary reaction" of carcinogenesis. (7) Primary liver cell carcinoma is found to be more frequent in posthepatitic than in postalcoholic, cryptogenic, and other cirrhosis and to be more frequent in australia-antigen positive than in australia-antigen negative cases. (8) Routine serological tumor antigen screening of patients with a precancerous disease is useful.
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PMID:Early detection of hepatoma: prospective study in liver cirrhosis using passive hemagglutination and the radioimmunoassay. 5 21

Even though Bleomycin is excreted in the urine in high concentrations, side effects in the urinary tract due to the chemical nature of this compound are seldom observed. With respect to treatment of gynecological carcinomas, it is, therefore, important to examine the effect that Bleomycin when treatment involves the use of Endoxan. Cytologically, one finds an increase in desquanmation of the transitional epithelium and an increase in degenerate cell forms. The homogenous eosinophilic cellular inclusions which are observed, are specific for neither Endoxan nor for Bleomycin treatment. The antibiotic effect of Bleomycin results in an aseptic cystitis. The urocytogramm is suitable for examining the epithelial changes of the urinary tract in context with the gynecological carcinoma treatment and also for determing tumor breakthough into the bladder.
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PMID:[Urocytogram in the treatment with bleomycin]. 5 14


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