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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Meningiomas examined by computed tomography (CT) often show an area of decreased density surrounding the tumor. Various explanations include edema of the adjacent brain, loculated or trapped subarachnoid fluid, widening of the subarachnoid space, tissue necrosis, and demyelination. The present report describes a case in which this zone of diminished density was a large cystic astrocytoma, overlying a subfrontal meningioma.
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PMID:Case report: diminished density surrounding a meningioma, verified to be an overlying cystic astrocytoma. 61 12

A care is described of an astrocytoma grade 1 arising from the floor of the third ventricle, operated upon transcallosally. No disconnection symptoms were produced. Five years later the patient has above normal intelligence and is attending school at normal grade level in spite of a CT scan suggesting recurrence of the tumor.
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PMID:Transcallosal approach to third ventricle tumor: case report. Partial removal of an infundibuloma (grade I astrocytoma arising from the floor of the third ventricle). 61 49

A ciliary body tumor that was believed clinically to be a malignant melanoma developed in a 28-year-old woman and led to enucleation of her eye. The light microscopic appearance of the tumor was interpreted by light microscopy as a neurogenic neoplasm, possibly a choristomatous astrocytoma. Electron microscopic studies disclosed the smooth muscle origin of the tumor. Results of experimental embryologic studies performed on lower animals have proved that the neural crest contributes most of the connective tissues, "mesectoderm," of the globe and orbit in these species. The occurrence of hybrid neurogenic-myogenic tumors in the human eye supports the applicability of these embryologic discoveries to man. The association of a pigmented nevus with the present tumor is additional evidence of the neural crest origin of mesectodermal leiomyomas, since melanocytes are well-recognized descendants from the neural crest.
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PMID:Mesectodermal leiomyoma of the ciliary body associated with a nevus. 64 98

Two cases of optic nerve neuritis are reported. The first had typical clinical symptoms and the other had an atypical course. In the case of the first patient an astrocytoma was found in the right frontal lobe. The aetiology of the second case was a meningioma of the tuberculum sellae. The clinical findings in our cases are discussed with regard to 58 cases in the literature. In all cases of optic neuritis with typical and atypical course a tumor of the central nervous system must always be taken into consideration.
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PMID:[On the differential diagnosis of bilateral retrobular optic neuritis (author's transl)]. 65 Dec 21

The authors give follow-up information on Case 59 of Cushing's 1931 series of cerebellar astrocytomas. The patient died with a malignant cerebellar astrocytoma 48 years after partial removal of a previously benign astrocytoma at the same site. Including the present one, there have been only five reported cases in which this has occurred. Ordinarily, juvenile pilocytic astrocytomas are of extremely genign character, and it is well established that even with incomplete resections patients have survived for years without progression of the tumor. Not all of the cases so reported can be wholly accepted as respresenting malignant transformation of the tumor, but may instead be instances of recurrence of an inherently benign glioma since the presence of features such as endothelial hyperplasia or nuclear atypicality in a juvenile pilocytic astrocytoma does not warrant is being classified as malignant. Features truly suggestive of malignancy are hypercellularity, frequent mitoses, necrosis, and, in some instances, a diffusely infiltrative growth pattern; all of these features were found in the present case.
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PMID:Malignant transformation in benign cerebellar astrocytoma. Case report. 66 Feb 55

A case of 26-year-old female with malignant astrocytoma was described. Intracerebral hemorrhage appeared in apoplectic fashion on two occasions and surgery was done after each attack. At the first operation, a hematoma in the right putaminal region was totally evacuated and a specimen from the cavity wall showed tumor cells which could not be classified histologically at that time. The patient fully recovered postoperatively. Astrocytoma was confirmed 4 months later by the second operation for the repeated intratumoral hemorrhage. Only a half of the tumor was removed by the third operation. It was apparent that the tumor occupied the site of the right basal ganglia and infiltrated the internal copsule. We discussed the massive intratumoral hemorrhage and propose a craniotomy instead of simple trepanation for the treatment of intracerebral hematoma in order to make adequate biopsy of the hematoma wall and to remove the coexisting tumor, if present.
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PMID:[Repeated intracerebral hemorrhage in malignant astrocytoma--a case of apoplectic manifestation (author's transl)]. 67 38

A child treated for a desmoplastic medulloblastoma of the left cerebellar hemisphere at the age of 10 months developed a malignant astrocytoma in the same site 11 years later. Theories of origin of the second tumor, particularly in relation to concepts of the genesis of medulloblastoma in general, are discussed.
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PMID:Development of cerebellar malignant astrocytoma at site of a medulloblastoma treated 11 years earlier. Case report. 68 8

Two cases with epidermoid and one case with dermoid in the 4th ventricle were treated in our clinic during the last one year. The clinical findings in these three cases were described, and dermoid and epidermoid tumors in the 4th ventricle were discussed dealing with the incidence and the characteristic features of the findings in CT scanning. The correct diagnosis of both epidermoid and dermoid in the 4th ventricle was done by CT-scanning which showed an irregular low density area of EMI No. -4 approximately 12 in the posterior fossa without any contrast media enhancement. The low density lesion could be differentiated by both angiogram and ventriculogram from arachnoid cyst, ependymoma, cystic astrocytoma and cystic hemangioblastoma in the 4th ventricle. Total removal of the tumor was performed on 2 cases, and a part of the tumor capsule attached to the medulla oblongata was left in the other case. All patients returned to their own job after operation.
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PMID:[Three cases of the dermoid and epidermoid tumors in the 4th ventricle (author's transl)]. 68 54

A total of 132 children, less than 15 years of age at the time of diagnosis of an intracranial supratentorial tumor, were followed from 1 to 40 years. The patient material was unselected and the follow-up 100%. 73 were boys and 59 were girls. The tumors were located in the lateral region of the brain in 70 children and in the midline in 62. Astrocytoma was the most common histological type, followed by craniopharyngioma. The occurrence of the most malignant tumor types was significantly higher in the lateral than in the midline region. 84 children survived for more than 1 month after the initial diagnosis or surgery, and 29 of these were alive 15 to 40 years after operation. 45% of the children with tumors situated laterally and 30% of those with midline tumors were alive after 15 years. 14% of those who survived at least 15 years had severe and 34% slight neurological defects.
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PMID:Clinical aspects and long-term prognosis in supratentorial tumors of infancy and childhood. 69 34

Thirteen gliomas from 55 neurosurgical specimens, derived from 25 adults and 30 children, have been successfully grown as subcutaneous xenografts in immune-deprived or nude mice. Only 2 of the 30 paediatric specimens implanted (6.7%), a medulloblastoma and an astrocytoma Grade III, have grown compared with 11 of the 25 adult specimen (44%) which were mostly astrocytomas Grade III. Tumour growth usually occurred several months after implantation, and karyotypic analysis confirmed their human origin in all cases. The histopathology of xenografted tumours correlated with the original surgical material, both after initial implantation and when tumours had been passaged several times. Observations on tumour growth in various types of immune-deprived mice indicated that, within certain limits, the immunological competence of the host mouse did not relate to take rates of primary implants, but could affect the take rate of passaged tumours.
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PMID:Growth of human gliomas in immune-deficient mice: a possible model for pre-clinical therapy studies. 69 41


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