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Query: UMLS:C0027651 (tumor)
 685,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred smooth muscle tumors arising in the gastrointestinal tract and retroperitoneum were reviewed in an attempt to define criteria for the diagnosis of leiomyosarcoma in these sites. On the basis of aggressive behavior, 56 of these neoplasms were diagnosed as leiomyosarcoma. Mitoses were found to be the most useful indicator of malignancy; all of the tumors with five or more mitoses/10 HPF behaved aggressively and smooth muscle tumors with this degree of mitotic activity should be diagnosed as leiomyosarcoma. A paucity of mitoses, however, is no assurance of benignity as nearly 40% of the leiomyosarcomas in this series had fewer than five mitoses/10 HPF. Tumor cell necrosis was closely associated with aggressive behavior even when mitoses were infrequent and it is doubtful that benign smooth muscle tumors develop extensive tumor cell necrosis. In the absence of the requisite number of mitoses or tumor necrosis, it is difficult to distinguish some leiomyosarcomas from leiomyomas, but tumor size, cellularity and cellular atypia may be helpful parameters when assessed together. The importance of these criteria in different anatomical sites is discussed. It is emphasized that the criteria for the diagnosis of leiomyosarcoma of the uterus do not apply to non-uterine smooth muscle tumors. The actuarial 2-year survival rate was as follows: gastric leiomyosarcoma, 40%; small intestinal leiomyosarcoma, 60%; and retroperitoneal leiomyosarcoma, 16%.
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PMID:Smooth muscle tumors of the gastrointestinal tract and retroperitoneum: a pathologic analysis of 100 cases. 83 38

Aggressive cemento-ossifying fibroma is the most aggressive tumor of all cementum-containing neoplasms. An extensive, destructive cemento-ossifying fibroma of the ethmoid region was found in a patient. To our knowledge, this is the first case of a cemento-ossifying fibroma in this location. A radical maxillectomy was ultimately required to control the tumor, preserving orbital contents. The unique site of origin is thought to be the result of an ectopic periodontal membrane or of a primitive mesenchymal cell rest.
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PMID:Cementomas. II. Aggressive cemento-ossifying fibroma of the ethmoid region. 86 75

Since 1947, we have treated 19 children with neuroblastoma whose first symptoms were paralysis or weakness of an extremity, and/or incontinence due to tumor in the spinal canal. In 18 patients, the spine tumor was part of a dumbbell tumor which was present in the adjacent paravertebral area and in one, no extraspinal tumor was found. Aggressive treatment was employed for all. In 17 children, the intraspinal tumor was treated by laminectomy and irradiation with and without chemotherapy. Radiation and chemotherapy were used for two. The extraspinal tumor was excised totally in six and partially in six. All 12 children received postoperative radiation and chemotherapy. In 6 children, the extraspinal tumor was treated only with radiation and chemotherapy. Nine of 19 children are alive without evidence of neuroblastoma. Thirteen patients showed either partial (6) or full (7) neurologic recovery. Survival was related to the child's age at diagnosis and the extent of disease. While 8 of 9 children under 1 yr of age survived, only 1 of 10 children over 1 yr survived. None of the 5 children with Stage IV disease at diagnosis could be saved. The degree and frequency of neurologic recovery were greatest in children whose neurologic symptoms had been present the shortest times and were equal among those who survived and those who died. The outlook for children who became paralyzed by neuroblastoma is not hopeless; therapy aimed at saving life or neurologic function is both worthwhile and rewarding.
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PMID:Prognosis for children with neuroblastoma presenting with paralysis. 87 30

The acinic cell tumor of salivary gland origin, once thought to be benign, is now known to be an incidiously slow growing malignant neoplasm with lethal potential. While the degree of malignant behavior of individual acinic cell tumors is notably variable, all must be treated with aggression. Traditional and current methods of treatment are reviewed; and, in conjunction with the tumors herein reported, guidelines for managment of this uncommon malignancy are suggested. Four cases have been reviewed in detail and critically analyzed. The pathology, including features of both light and electron microscopy, in included--particularly in relation to the oncocytoid areas identified in from 10% to 40% of the parenchymal cells of our tumors. Since an accurate histopathologic diagnosis is the first step in the establishment of a proper treatment plan, pitfalls in histologic diagnosis have been stressed.
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PMID:Acinic cell tumors of salivary gland origin. 89 8

Hemangiopericytoma, a rare vascular tumor characterized by pericytes, has been confused with benign lesions. The tumor cannot be identified clinically and requires histopathologic examination. Although the five year survival rate is good, the 10 year survival rate is poor for tumors in the head and neck region. Aggressive treatment with wide surgical margins appears warranted. Surgery in combination with radiotherapy has improved the poor prognosis. A case of hemangiopericytoma of the parotid gland, the eighth known in the surgical literature, is presented which illustrates the difficulty in the diagnosis and treatment of this lesion.
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PMID:Hemangiopericytoma of the parotid gland with a review of the literature. 92 26

Three juvenile patients with cerebellar astrocytomas which have seeded the spinal subarachnoid space are presented. Histologic verification of the similarity between the posterior fossa tumor and its spinal implant was obtained in two of the three patients. The cerebellar tumors in all cases have been benign (grade I),and the behavior, other than their seeding has also been indolent. Review of pertinent literature discloses no similar experience with cerebellar astrocytomas. Aggressive therapy is advocated for the rare patient with subarachnoid seeding from this benign lesion.
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PMID:Spinal cord seeding from cerebellar astrocytomas. 97 37

Primary patellar neoplasms are distinctly unusual. A rare case of patellar giant cell tumor which caused clinical, radiographic, and histologic confusion is described. The lesion progressed rapidly, underscoring the potential aggressive behavior of the tumor. Amputation is the preferred treatment. A review of the literature is also presented.
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PMID:Patellar giant cell tumor. 97 77

A 72-year-old patient had a meningotheliomatous meningioma that invaded through the skull and into temporalis muscle. One year following craniotomy for removal of the neoplasm, he developed headaches, diplopia, and proptosis of the left eye. Biopsy of the orbital contents revealed a malignant supporting tissue neoplasm having a resemblance to the previous meningioma. No curative therapy was possible and the patient died 33 months after diagnosis. Autopsy examination showed extensive residual intracranial neoplasm and a 3-cm metastasis in the liver. The metastatic tumor appeared similar to the meningioma and did not appear malignant histologically. The case illustrates the distinct histologic variations in meningiomas and the difficulties in predicting their biologic activity. Aggressive local behavior may indicate possible malignant areas in the neoplasm. Therefore, examination of the neoplasm should be thorough. Such a correlation may suggest malignant biologic potential.
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PMID:Meningioma with sarcomatous change and hepatic metastasis. 103 80

Of 30 children treated for embryonal rhabdomyosarcoma the primary site of tumor was the bladder in 14 cases (9 boys and 5 girls) and the prostate in 16 cases. The mean age at diagnosis was 3 years in patients with bladder sarcoma and 6.5 years in patients with sarcoma of the prostate. Over-all survival rate has been 23 per cent--5 children with rhabdomyosarcoma of the bladder and 2 with rhadbomyosarcoma of the porstate are alive from 1 1/2 to 23 years postoperatively. Aggressive coordinated treatment with surgery, radiotherapy and cyclic combination chemotherapy is recommended.
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PMID:Embryonal rhabdomyosarcoma of the bladder and prostate in childhood. 112 15

A case of a functioning interstitial-cell tumor in a 12-year-old Negro boy is reported. The patient manifested precocious puberty, with signs of sexually aggressive behavior. The ultra-structural studies of the tumor showed features similar to those of the few cases previously reported in the literature. One characteristic finding was the presence of numerous membranous whorls within the cytoplasm. The cells grown in tissue culture were maintained for at least 9 weeks and were confirmed as testicular interstitial cells. Ultrastructurally they were similar to the cells in vivo, as evidenced by the finding of cytoplasmic organelles related to steroid synthesis.
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PMID:Interstitial-cell tumor of the testis. Tissue culture and ultrastructural studies. 116 31


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