Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
103,950 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 6290
nodal 4156
Mol 2530
MRI 1835
p53 1812
She 1548
osteosarcoma 1352
FDG 1218
epidermal growth factor receptor 1097
TNM 979
HER2 977
E-cadherin 972
vimentin 952
estrogen receptor 943
carcinoembryonic antigen 905
vascular endothelial growth factor 884
cytokine 875
collagen 873
tyrosine kinase 798
cytokeratin 776
Ki-67 714
BRAF 702
CEA 695
prostate-specific antigen 689
somatostatin 674
interferon 652
thyroglobulin 636
rhabdomyosarcoma 593
CD8 569
interleukin-2 557
progesterone receptor 540
EGFR 536
cage 533
matrix metalloproteinase 529
alkaline phosphatase 512
CD44 511
Pol 500
colon carcinoma 499
fibronectin 484
lymphoid 468
VEGF 457
PSA 451
mTOR 437
calcitonin 431
MMP-9 407
mucin 401
AKT 398
hormone receptor 394
catenin 387
IFN 381
MMP-2 374
KRAS 366
CD34 365
glycoprotein 363
IL-2 355
androgen receptor 353
PI3K 353
desmin 353
CD4 348
alpha-fetoprotein 343
chemokine 342
erbB-2 339
reserved 331
S100 317
urokinase-type plasminogen activator 312
CK20 309
synaptophysin 307
CXCR4 305
insulin 288
chorionic gonadotropin 278
keratin 276
MAPK 273
ras 264
ERK 262
neuron-specific enolase 260
tumor necrosis factor 258
neu 257
PTEN 253
PD-L1 250
chromogranin A 249
more...
Disease
metastases 103950
tumor 46273
cancer 42306
carcinoma 15367
breast cancer 10569
melanoma 8299
primary tumor 7239
adenocarcinoma 6206
prostate cancer 4693
colorectal cancer 4055
lung cancer 3570
squamous cell carcinoma 3566
liver metastases 3433
tumor growth 3340
tumor progression 3138
renal cell carcinoma 3027
sarcoma 2469
bone metastases 2424
lung metastases 2390
gastric cancer 2107
hepatocellular carcinoma 2053
lung carcinoma 1736
brain metastases 1683
osteosarcoma 1656
colon cancer 1619
metastatic breast cancer 1588
tumorigenesis 1379
non-small cell lung cancer 1376
lymphoma 1325
pancreatic cancer 1268
thyroid cancer 1250
carcinogenesis 1246
metastatic melanoma 1235
carcinoid 1190
Melanoma 1122
ovarian cancer 1087
aggressiveness 920
residual disease 855
neuroblastoma 854
rectal cancer 831
lymphadenopathy 816
bladder cancer 772
adenoma 742
cervical cancer 668
aggression 662
cutaneous melanoma 661
fibrosarcoma 658
epithelial ovarian cancer 639
rhabdomyosarcoma 635
leiomyosarcoma 621
esophageal cancer 612
Ewing's sarcoma 605
anemia 601
endometrial cancer 585
esophageal cancer 571
carcinomatosis 535
small cell lung cancer 522
head and neck cancer 514
hypercalcemia 511
mole 504
angiosarcoma 502
uterus 502
medullary thyroid carcinoma 500
skin cancer 492
bronchogenic carcinoma 492
renal cancer 487
metastatic renal cell carcinoma 486
leukemia 483
multiple myeloma 479
carcinoma of the breast 471
ductal carcinoma 466
solid tumor 456
PSA 451
meningioma 451
cirrhosis 445
systemic disease 432
pheochromocytoma 431
papillary thyroid cancer 427
WT1 421
chondrosarcoma 420
more...
Symptom
pain 2896
abdominal pain 694
diarrhea 583
dyspnea 461
nausea 456
vomiting 447
headache 442
fatigue 419
bone pain 383
anesthesia 372
weakness 323
back pain 319
cough 308
anorexia 304
nausea and vomiting 214
chest pain 182
seizures 180
discomfort 176
discomfort 171
hemoptysis 163
cachexia 134
epigastric pain 130
low back pain 117
ENT 110
collapse 109
shortness of breath 108
hepatomegaly 104
Ill 104
analgesia 103
erythema 103
cancer pain 94
flank pain 91
constipation 89
numbness 82
flushing 82
hoarseness 78
respiratory distress 78
paresthesia 74
splenomegaly 72
dizziness 70
lethargy 65
ataxia 64
abdominal discomfort 60
paresis 59
asthenia 58
chills 56
dysuria 50
colic 42
polyuria 42
exhaustion 41
paraparesis 40
neck pain 38
starvation 37
vertigo 36
masculinization 34
acute abdomen 34
myalgia 34
overweight 32
ophthalmoplegia 32
hip pain 32
blurred vision 32
sleepiness 31
pelvic pain 30
decreased appetite 30
arthralgia 30
tinnitus 29
exertional dyspnea 29
dysarthria 28
abdominal fullness 27
acidity 27
polydipsia 27
hemiplegia 27
syncope 26
hepatosplenomegaly 26
regurgitation 26
facial pain 24
shoulder pain 24
hypothermia 23
Sister Mary Joseph's nodule 23
acute abdominal pain 23
more...
Drug
Dermatol 1074
Cardiovasc 530
IL-2 361
CSF 272
Adriamycin 267
IFN-gamma 214
ENT 191
CPT-11 169
CTX 159
Herceptin 153
HCG 144
Paraffin 117
Docetaxel 110
lysine 109
uPA 99
Bevacizumab 99
Taxol 97
PTC 87
Imatinib 86
CAM 86
MAP 82
ROC 81
Leaf 78
Cetuximab 73
Oxaliplatin 69
Lipiodol 64
Leucovorin 59
Irinotecan 57
Sorafenib 57
Zoledronic acid 57
G-CSF 52
MTC 52
PTH 52
ADM 52
Monit 51
ABC 51
ROS 48
Gleevec 48
CTC 46
ETS 45
CTC 45
Zoledronic acid 45
CTX 44
DMSA 43
Taxotere 41
Portal 40
Gefitinib 40
Denosumab 39
Thyroglobulin 39
CTX 38
Etoposide 37
VCR 35
GEO 32
vitamin E 32
ADR 30
Gelatin 29
EHDP 28
Erlotinib 28
Ipilimumab 27
EE2 27
Vinorelbine 27
BLM 26
Fulvestrant 25
Nephron 25
CDX 24
DM1 24
MRC 24
CDX 24
Fluorescein 23
Gel 23
Zoladex 23
Lovastatin 23
ICI 23
Indomethacin 23
Clodronate 21
Sandostatin 21
Nephron 21
Zoladex 21
Sandostatin 21
G418 20
more...
Enzyme
ERK 2746
mitogen-activated protein kinase 668
prostate-specific antigen 665
focal adhesion kinase 528
alkaline phosphatase 512
urokinase-type plasminogen activator 372
luciferase 361
prostate-specific membrane antigen 264
lactate dehydrogenase 261
reverse transcriptase 261
protein kinase 250
MEK 249
collagenase 196
acid phosphatase 186
matrix metalloproteinase 2 153
MDP 152
peroxidase 147
CD10 144
APC 137
protein kinase C 130
caspase-3 127
MMP 124
tyrosinase 122
trypsin 104
thrombin 97
matrix metalloproteinase 9 95
plasmin 94
PARP 93
proteasome 90
gamma-glutamyl transpeptidase 89
thymidine kinase 87
catalase 86
ACS 86
P-glycoprotein 84
enolase 83
phosphatidylinositol 3-kinase 81
cathepsin D 77
cathepsin B 73
alanine aminotransferase 71
topoisomerase 66
RNA polymerase 66
topoisomerase 65
ATPase 64
thymidylate synthase 63
MMP-3 59
beta-galactosidase 59
succinate dehydrogenase 56
aspartate aminotransferase 53
neuraminidase 53
transcriptase 52
phosphoinositide 3-kinase 52
hyaluronidase 49
tissue plasminogen activator 49
lysozyme 48
hyaluronidase 45
AMP-activated protein kinase 42
creatine kinase 41
calcineurin 41
dihydropyrimidine dehydrogenase 41
glutathione S-transferase 40
renin 39
superoxide dismutase 39
NOS 38
aldehyde dehydrogenase 38
cdc2 38
GSK 37
RNase 37
aldehyde dehydrogenase 36
RNase 36
carbonic anhydrase 36
aldehyde dehydrogenase 36
aldehyde dehydrogenase 36
aldehyde dehydrogenase 36
lysyl oxidase 35
cathepsin K 35
DCF 34
lipoxygenase 34
MAP 34
firefly luciferase 33
thromboplastin 32
more...
Compound
Clin 10435
Dec 7224
DNA 3368
TNM 979
MDA 918
iodine 863
calcium 696
5-FU 624
oxygen 552
glucose 526
tyrosine 490
water 409
acetate 383
Thyroid 374
methionine 346
Adriamycin 344
His 299
fluorine 279
phosphate 272
sodium 271
galactose 259
DDP 246
nitric oxide 228
iron 217
TSH 215
sulfate 193
serine 192
MEK 191
DTPA 191
DIC 181
TNF 177
arginine 171
folinic acid 169
CPT-11 167
MTT 167
creatinine 165
BCG 164
Optimal 162
barium 162
CTX 159
ACTH 154
CAM 150
lysine 149
ATP 138
nitrogen 135
ethanol 134
DBA 133
PEG 131
leucine 129
Vimentin 127
MCA 125
MCA 124
Cardiol 122
SCC 121
Tamoxifen 120
ADR 120
Tamoxifen 117
MMC 116
Androgen 115
cysteine 113
VP-16 113
cobalt 112
A 71 111
zinc 111
strontium 110
silver 110
retinoic acid 110
CO2 108
ASA 105
DBA 103
DBA 103
formaldehyde 102
Methotrexate 101
Paclitaxel 100
Adrenal 99
Estrogen 97
Gemcitabine 97
Gemcitabine 97
Phe 94
threonine 93
more...