Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
6290
nodal
4156
Mol
2530
MRI
1835
p53
1812
She
1548
osteosarcoma
1352
FDG
1218
epidermal growth factor receptor
1097
TNM
979
HER2
977
E-cadherin
972
vimentin
952
estrogen receptor
943
carcinoembryonic antigen
905
vascular endothelial growth factor
884
cytokine
875
collagen
873
tyrosine kinase
798
cytokeratin
776
Ki-67
714
BRAF
702
CEA
695
prostate-specific antigen
689
somatostatin
674
interferon
652
thyroglobulin
636
rhabdomyosarcoma
593
CD8
569
interleukin-2
557
progesterone receptor
540
EGFR
536
cage
533
matrix metalloproteinase
529
alkaline phosphatase
512
CD44
511
Pol
500
colon carcinoma
499
fibronectin
484
lymphoid
468
VEGF
457
PSA
451
mTOR
437
calcitonin
431
MMP-9
407
mucin
401
AKT
398
hormone receptor
394
catenin
387
IFN
381
MMP-2
374
KRAS
366
CD34
365
glycoprotein
363
IL-2
355
androgen receptor
353
PI3K
353
desmin
353
CD4
348
alpha-fetoprotein
343
chemokine
342
erbB-2
339
reserved
331
S100
317
urokinase-type plasminogen activator
312
CK20
309
synaptophysin
307
CXCR4
305
insulin
288
chorionic gonadotropin
278
keratin
276
MAPK
273
ras
264
ERK
262
neuron-specific enolase
260
tumor necrosis factor
258
neu
257
PTEN
253
PD-L1
250
chromogranin A
249
more...
Disease
metastases
103950
tumor
46273
cancer
42306
carcinoma
15367
breast cancer
10569
melanoma
8299
primary tumor
7239
adenocarcinoma
6206
prostate cancer
4693
colorectal cancer
4055
lung cancer
3570
squamous cell carcinoma
3566
liver metastases
3433
tumor growth
3340
tumor progression
3138
renal cell carcinoma
3027
sarcoma
2469
bone metastases
2424
lung metastases
2390
gastric cancer
2107
hepatocellular carcinoma
2053
lung carcinoma
1736
brain metastases
1683
osteosarcoma
1656
colon cancer
1619
metastatic breast cancer
1588
tumorigenesis
1379
non-small cell lung cancer
1376
lymphoma
1325
pancreatic cancer
1268
thyroid cancer
1250
carcinogenesis
1246
metastatic melanoma
1235
carcinoid
1190
Melanoma
1122
ovarian cancer
1087
aggressiveness
920
residual disease
855
neuroblastoma
854
rectal cancer
831
lymphadenopathy
816
bladder cancer
772
adenoma
742
cervical cancer
668
aggression
662
cutaneous melanoma
661
fibrosarcoma
658
epithelial ovarian cancer
639
rhabdomyosarcoma
635
leiomyosarcoma
621
esophageal cancer
612
Ewing's sarcoma
605
anemia
601
endometrial cancer
585
esophageal cancer
571
carcinomatosis
535
small cell lung cancer
522
head and neck cancer
514
hypercalcemia
511
mole
504
angiosarcoma
502
uterus
502
medullary thyroid carcinoma
500
skin cancer
492
bronchogenic carcinoma
492
renal cancer
487
metastatic renal cell carcinoma
486
leukemia
483
multiple myeloma
479
carcinoma of the breast
471
ductal carcinoma
466
solid tumor
456
PSA
451
meningioma
451
cirrhosis
445
systemic disease
432
pheochromocytoma
431
papillary thyroid cancer
427
WT1
421
chondrosarcoma
420
more...
Symptom
pain
2896
abdominal pain
694
diarrhea
583
dyspnea
461
nausea
456
vomiting
447
headache
442
fatigue
419
bone pain
383
anesthesia
372
weakness
323
back pain
319
cough
308
anorexia
304
nausea and vomiting
214
chest pain
182
seizures
180
discomfort
176
discomfort
171
hemoptysis
163
cachexia
134
epigastric pain
130
low back pain
117
ENT
110
collapse
109
shortness of breath
108
hepatomegaly
104
Ill
104
analgesia
103
erythema
103
cancer pain
94
flank pain
91
constipation
89
numbness
82
flushing
82
hoarseness
78
respiratory distress
78
paresthesia
74
splenomegaly
72
dizziness
70
lethargy
65
ataxia
64
abdominal discomfort
60
paresis
59
asthenia
58
chills
56
dysuria
50
colic
42
polyuria
42
exhaustion
41
paraparesis
40
neck pain
38
starvation
37
vertigo
36
masculinization
34
acute abdomen
34
myalgia
34
overweight
32
ophthalmoplegia
32
hip pain
32
blurred vision
32
sleepiness
31
pelvic pain
30
decreased appetite
30
arthralgia
30
tinnitus
29
exertional dyspnea
29
dysarthria
28
abdominal fullness
27
acidity
27
polydipsia
27
hemiplegia
27
syncope
26
hepatosplenomegaly
26
regurgitation
26
facial pain
24
shoulder pain
24
hypothermia
23
Sister Mary Joseph's nodule
23
acute abdominal pain
23
more...
Drug
Dermatol
1074
Cardiovasc
530
IL-2
361
CSF
272
Adriamycin
267
IFN-gamma
214
ENT
191
CPT-11
169
CTX
159
Herceptin
153
HCG
144
Paraffin
117
Docetaxel
110
lysine
109
uPA
99
Bevacizumab
99
Taxol
97
PTC
87
Imatinib
86
CAM
86
MAP
82
ROC
81
Leaf
78
Cetuximab
73
Oxaliplatin
69
Lipiodol
64
Leucovorin
59
Irinotecan
57
Sorafenib
57
Zoledronic acid
57
G-CSF
52
MTC
52
PTH
52
ADM
52
Monit
51
ABC
51
ROS
48
Gleevec
48
CTC
46
ETS
45
CTC
45
Zoledronic acid
45
CTX
44
DMSA
43
Taxotere
41
Portal
40
Gefitinib
40
Denosumab
39
Thyroglobulin
39
CTX
38
Etoposide
37
VCR
35
GEO
32
vitamin E
32
ADR
30
Gelatin
29
EHDP
28
Erlotinib
28
Ipilimumab
27
EE2
27
Vinorelbine
27
BLM
26
Fulvestrant
25
Nephron
25
CDX
24
DM1
24
MRC
24
CDX
24
Fluorescein
23
Gel
23
Zoladex
23
Lovastatin
23
ICI
23
Indomethacin
23
Clodronate
21
Sandostatin
21
Nephron
21
Zoladex
21
Sandostatin
21
G418
20
more...
Enzyme
ERK
2746
mitogen-activated protein kinase
668
prostate-specific antigen
665
focal adhesion kinase
528
alkaline phosphatase
512
urokinase-type plasminogen activator
372
luciferase
361
prostate-specific membrane antigen
264
lactate dehydrogenase
261
reverse transcriptase
261
protein kinase
250
MEK
249
collagenase
196
acid phosphatase
186
matrix metalloproteinase 2
153
MDP
152
peroxidase
147
CD10
144
APC
137
protein kinase C
130
caspase-3
127
MMP
124
tyrosinase
122
trypsin
104
thrombin
97
matrix metalloproteinase 9
95
plasmin
94
PARP
93
proteasome
90
gamma-glutamyl transpeptidase
89
thymidine kinase
87
catalase
86
ACS
86
P-glycoprotein
84
enolase
83
phosphatidylinositol 3-kinase
81
cathepsin D
77
cathepsin B
73
alanine aminotransferase
71
topoisomerase
66
RNA polymerase
66
topoisomerase
65
ATPase
64
thymidylate synthase
63
MMP-3
59
beta-galactosidase
59
succinate dehydrogenase
56
aspartate aminotransferase
53
neuraminidase
53
transcriptase
52
phosphoinositide 3-kinase
52
hyaluronidase
49
tissue plasminogen activator
49
lysozyme
48
hyaluronidase
45
AMP-activated protein kinase
42
creatine kinase
41
calcineurin
41
dihydropyrimidine dehydrogenase
41
glutathione S-transferase
40
renin
39
superoxide dismutase
39
NOS
38
aldehyde dehydrogenase
38
cdc2
38
GSK
37
RNase
37
aldehyde dehydrogenase
36
RNase
36
carbonic anhydrase
36
aldehyde dehydrogenase
36
aldehyde dehydrogenase
36
aldehyde dehydrogenase
36
lysyl oxidase
35
cathepsin K
35
DCF
34
lipoxygenase
34
MAP
34
firefly luciferase
33
thromboplastin
32
more...
Compound
Clin
10435
Dec
7224
DNA
3368
TNM
979
MDA
918
iodine
863
calcium
696
5-FU
624
oxygen
552
glucose
526
tyrosine
490
water
409
acetate
383
Thyroid
374
methionine
346
Adriamycin
344
His
299
fluorine
279
phosphate
272
sodium
271
galactose
259
DDP
246
nitric oxide
228
iron
217
TSH
215
sulfate
193
serine
192
MEK
191
DTPA
191
DIC
181
TNF
177
arginine
171
folinic acid
169
CPT-11
167
MTT
167
creatinine
165
BCG
164
Optimal
162
barium
162
CTX
159
ACTH
154
CAM
150
lysine
149
ATP
138
nitrogen
135
ethanol
134
DBA
133
PEG
131
leucine
129
Vimentin
127
MCA
125
MCA
124
Cardiol
122
SCC
121
Tamoxifen
120
ADR
120
Tamoxifen
117
MMC
116
Androgen
115
cysteine
113
VP-16
113
cobalt
112
A 71
111
zinc
111
strontium
110
silver
110
retinoic acid
110
CO2
108
ASA
105
DBA
103
DBA
103
formaldehyde
102
Methotrexate
101
Paclitaxel
100
Adrenal
99
Estrogen
97
Gemcitabine
97
Gemcitabine
97
Phe
94
threonine
93
more...