Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 6290
nodal 4156
Mol 2530
MRI 1835
p53 1812
She 1548
osteosarcoma 1352
FDG 1218
epidermal growth factor receptor 1097
TNM 979
HER2 977
E-cadherin 972
vimentin 952
estrogen receptor 943
carcinoembryonic antigen 905
vascular endothelial growth factor 884
cytokine 875
collagen 873
tyrosine kinase 798
cytokeratin 776
Ki-67 714
BRAF 702
CEA 695
prostate-specific antigen 689
somatostatin 674
interferon 652
thyroglobulin 636
rhabdomyosarcoma 593
CD8 569
interleukin-2 557
progesterone receptor 540
EGFR 536
cage 533
matrix metalloproteinase 529
alkaline phosphatase 512
CD44 511
Pol 500
colon carcinoma 499
fibronectin 484
lymphoid 468
VEGF 457
PSA 451
mTOR 437
calcitonin 431
MMP-9 407
mucin 401
AKT 398
hormone receptor 394
catenin 387
IFN 381
MMP-2 374
KRAS 366
CD34 365
glycoprotein 363
IL-2 355
desmin 353
androgen receptor 353
PI3K 353
CD4 348
alpha-fetoprotein 343
chemokine 342
erbB-2 339
reserved 331
S100 317
urokinase-type plasminogen activator 312
CK20 309
synaptophysin 307
CXCR4 305
insulin 288
chorionic gonadotropin 278
keratin 276
MAPK 273
ras 264
ERK 262
neuron-specific enolase 260
tumor necrosis factor 258
neu 257
PTEN 253
PD-L1 250
chromogranin A 249
PD-1 247
albumin 243
KIT 231
p16 229
metastasis suppressor 227
IL-6 226
CD31 225
aromatase 223
prostate specific antigen 220
pT1 220
lectin 219
somatostatin receptor 217
IFN-gamma 217
p21 217
gastrin 217
CXCL12 216
epidermal growth factor 216
lactate dehydrogenase 216
CK7 215
beta-catenin 212
PC-3 212
receptor tyrosine kinase 212
F10 211
thymus 211
Bcl-2 210
smooth muscle actin 207
N-cadherin 202
HLA 198
pT3 196
proliferating cell nuclear antigen 194
MEK 193
polypeptide 193
prostate-specific membrane antigen 192
AE1 190
MET 190
hepatocyte growth factor 186
acid phosphatase 185
PIK3CA 182
lymphokine 181
cell adhesion molecule 180
interferon-alpha 178
gut 178
TNF 177
CSF 176
matrix metalloproteinase 2 174
MIB 172
cyclin D1 172
bcl-2 171
MMP9 169
adhesion molecule 168
IL-8 167
caspase-3 166
proto-oncogene 165
histone 164
metalloproteinase 163
ERK1 163
EGF 163
EMT 162
Rho 162
thyroid hormone 162
PC3 161
interleukin 2 157
p63 156
cytokeratin 19 156
c-kit 155
AE3 154
RET 154
MDP 152
nm23 152
NRAS 152
STAT3 151
EMA 150
ACTH 150
parathyroid hormone-related protein 149
fused 149
parathyroid hormone 147
CD56 147
p38 146
TGF-beta 146
tumour suppressor 145
more...
Disease
metastases 103950
tumor 46273
cancer 42306
carcinoma 15367
breast cancer 10569
melanoma 8299
primary tumor 7239
adenocarcinoma 6206
prostate cancer 4693
colorectal cancer 4055
lung cancer 3570
squamous cell carcinoma 3566
liver metastases 3433
tumor growth 3340
tumor progression 3138
renal cell carcinoma 3027
sarcoma 2469
bone metastases 2424
lung metastases 2390
gastric cancer 2107
hepatocellular carcinoma 2053
lung carcinoma 1736
brain metastases 1683
osteosarcoma 1656
colon cancer 1619
metastatic breast cancer 1588
tumorigenesis 1379
non-small cell lung cancer 1376
lymphoma 1325
pancreatic cancer 1268
thyroid cancer 1250
carcinogenesis 1246
metastatic melanoma 1235
carcinoid 1190
Melanoma 1122
ovarian cancer 1087
aggressiveness 920
residual disease 855
neuroblastoma 854
rectal cancer 831
lymphadenopathy 816
bladder cancer 772
adenoma 742
cervical cancer 668
aggression 662
cutaneous melanoma 661
fibrosarcoma 658
epithelial ovarian cancer 639
rhabdomyosarcoma 635
leiomyosarcoma 621
esophageal cancer 612
Ewing's sarcoma 605
anemia 601
endometrial cancer 585
esophageal cancer 571
carcinomatosis 535
small cell lung cancer 522
head and neck cancer 514
hypercalcemia 511
mole 504
uterus 502
angiosarcoma 502
medullary thyroid carcinoma 500
bronchogenic carcinoma 492
skin cancer 492
renal cancer 487
metastatic renal cell carcinoma 486
leukemia 483
multiple myeloma 479
carcinoma of the breast 471
ductal carcinoma 466
solid tumor 456
PSA 451
meningioma 451
cirrhosis 445
systemic disease 432
pheochromocytoma 431
papillary thyroid cancer 427
WT1 421
chondrosarcoma 420
liver cancer 418
carcinoma of the breast 413
Prostate Cancer 409
neuroendocrine tumor 405
choriocarcinoma 401
thrombocytopenia 397
neutropenia 397
prostatic adenocarcinoma 396
glioma 392
teratoma 391
dysplasia 382
hypertension 379
Dukes 375
Merkel cell carcinoma 368
pneumonia 364
seminoma 364
spinal cord compression 363
uveal melanoma 362
bone disease 362
MCF 362
tumor angiogenesis 361
brain tumor 356
transitional cell carcinoma 350
malignant fibrous histiocytoma 344
hemangioma 343
mammary tumor 342
glioblastoma 340
SCID 336
uterine cervix 330
neuroendocrine carcinoma 325
Osteosarcoma 323
Osteosarcoma 323
lymphatic vessels 322
mesothelioma 321
stromal tumors 321
liposarcoma 318
basal cell carcinoma 317
multiple endocrine neoplasia 316
testicular cancer 313
Hodgkin's disease 312
dysphagia 309
paraganglioma 308
pathological fracture 301
carcinoid syndrome 300
gastrointestinal stromal tumor 299
medulloblastoma 296
skin metastases 295
diabetes 294
liver cancer 292
rare disease 290
bowel obstruction 287
ductal carcinoma in situ 284
osteoporosis 278
liver disease 275
sepsis 257
carcinoma in situ 255
Hepatocellular carcinoma 241
retinoblastoma 241
Lymph node metastases 236
depression 234
sepsis 228
germ cell tumor 228
Colon 227
Colon 227
adrenocortical carcinoma 227
Colon 227
tuberculosis 220
synovial sarcoma 219
goiter 218
vagina 217
mole 214
invasive cancer 211
ureter 211
sarcoidosis 210
schwannoma 206
laryngeal cancer 203
myelosuppression 202
Hippel 200
glioblastoma multiforme 197
leukopenia 195
more...
Symptom
pain 2896
abdominal pain 694
diarrhea 583
dyspnea 461
nausea 456
vomiting 447
headache 442
fatigue 419
bone pain 383
anesthesia 372
weakness 323
back pain 319
cough 308
anorexia 304
nausea and vomiting 214
chest pain 182
seizures 180
discomfort 176
discomfort 171
hemoptysis 163
cachexia 134
epigastric pain 130
low back pain 117
ENT 110
collapse 109
shortness of breath 108
Ill 104
hepatomegaly 104
analgesia 103
erythema 103
cancer pain 94
flank pain 91
constipation 89
flushing 82
numbness 82
respiratory distress 78
hoarseness 78
paresthesia 74
splenomegaly 72
dizziness 70
lethargy 65
ataxia 64
abdominal discomfort 60
paresis 59
asthenia 58
chills 56
dysuria 50
polyuria 42
colic 42
exhaustion 41
paraparesis 40
neck pain 38
starvation 37
vertigo 36
masculinization 34
myalgia 34
acute abdomen 34
overweight 32
ophthalmoplegia 32
blurred vision 32
hip pain 32
sleepiness 31
pelvic pain 30
decreased appetite 30
arthralgia 30
tinnitus 29
exertional dyspnea 29
dysarthria 28
polydipsia 27
acidity 27
abdominal fullness 27
hemiplegia 27
syncope 26
hepatosplenomegaly 26
regurgitation 26
facial pain 24
shoulder pain 24
Sister Mary Joseph's nodule 23
acute abdominal pain 23
hypothermia 23
right upper quadrant pain 22
stridor 22
night sweats 21
nipple discharge 21
nipple discharge 21
intestinal bleeding 20
tenesmus 20
leg edema 20
hot flushes 19
myoclonus 19
clubbing 19
otalgia 19
oliguria 18
functional recovery 18
angina 18
knee pain 18
hot flashes 17
bloating 17
leg pain 17
productive cough 15
fever of unknown origin 15
testicular pain 14
pleuritic chest pain 14
urinary frequency 14
HSA 13
anal pain 13
cyanosis 13
sciatica 13
pallor 13
emaciation 12
distraction 12
agitation 12
thigh pain 11
tremor 11
insomnia 11
prostatism 11
orthopnea 11
Wind 10
memory loss 10
heartburn 10
tingling 10
sore throat 10
persistent cough 10
tonic-clonic seizure 9
loin pain 9
tachypnea 9
spasm 9
non-productive cough 8
wheezing 8
eye pain 8
consciousness disturbance 8
penile lesion 8
nasal discharge 8
rhinorrhea 8
dry skin 7
dysesthesia 7
arm pain 7
peau d'orange 7
neuralgia 7
dental pain 7
Cushingoid 7
acute pain 7
neck stiffness 7
Scratch 7
Cushingoid 7
breakthrough pain 7
Flu-like symptoms 7
hypoproteinemia 7
hopelessness 6
acute stress 6
chronic back pain 6
renal colic 6
chronic cough 6
cerebellar ataxia 6
menopausal symptoms 6
thinning 6
excessive sweating 5
dyschezia 5
Welt 5
right lower quadrant pain 5
more...
Drug
Dermatol 1074
Cardiovasc 530
IL-2 361
CSF 272
Adriamycin 267
IFN-gamma 214
ENT 191
CPT-11 169
CTX 159
Herceptin 153
HCG 144
Paraffin 117
Docetaxel 110
lysine 109
uPA 99
Bevacizumab 99
Taxol 97
PTC 87
Imatinib 86
CAM 86
MAP 82
ROC 81
Leaf 78
Cetuximab 73
Oxaliplatin 69
Lipiodol 64
Leucovorin 59
Sorafenib 57
Irinotecan 57
Zoledronic acid 57
MTC 52
PTH 52
ADM 52
G-CSF 52
ABC 51
Monit 51
Gleevec 48
ROS 48
CTC 46
ETS 45
Zoledronic acid 45
CTC 45
CTX 44
DMSA 43
Taxotere 41
Portal 40
Gefitinib 40
Thyroglobulin 39
Denosumab 39
CTX 38
Etoposide 37
VCR 35
GEO 32
vitamin E 32
ADR 30
Gelatin 29
Erlotinib 28
EHDP 28
Ipilimumab 27
Vinorelbine 27
EE2 27
BLM 26
Nephron 25
Fulvestrant 25
CDX 24
CDX 24
DM1 24
MRC 24
Lovastatin 23
Fluorescein 23
Zoladex 23
Gel 23
ICI 23
Indomethacin 23
Clodronate 21
Zoladex 21
Sandostatin 21
Sandostatin 21
Nephron 21
Spectrum 20
G418 20
TTC 20
VCR 20
ACT 20
TAC 19
Everolimus 19
IFN-beta 18
ascorbate 17
Fotemustine 17
Urokinase 17
Pemetrexed 16
Xeloda 16
APD 16
IL-11 16
Asn 16
p75 15
ETA 14
Gemzar 14
Estracyt 13
lactose 13
NVP 13
PDL 13
EPI 13
Mitomycin-C 13
Meth 13
Imiquimod 12
Pertuzumab 12
Gelfoam 12
RFP 12
Levovist 12
SrCl2 12
Estracyt 12
Retinoic acid 12
Gastro 12
Luteinizing 12
ALA 12
Mutagen 11
Albumin 11
DNase I 11
Tetrofosmin 11
Depo-Provera 11
Aredia 10
caffeine 10
Arimidex 10
Fluorescein 10
Glucagon 10
Vandetanib 10
OctreoScan 10
Navelbine 10
Glutathione 10
Indocyanine green 10
NBT 10
Sunitinib malate 10
TAT 10
ProstaScint 10
NADH 9
DHT 9
CTA 9
balanced salt solution 9
MDM 9
Gd-BOPTA 9
Isosulfan blue 9
CPM 9
Activin 9
Trabectedin 9
FSH-beta 9
Novantrone 9
Ibandronate 9
Angiotensin II 9
Thyrogen 9
DHT 9
CCL 8
Ketoconazole 8
Vena 8
AMC 8
nitroglycerin 8
Estrogens 8
Vena 8
Spectrum 8
Diphenhydramine 8
more...
Enzyme
ERK 2746
mitogen-activated protein kinase 668
prostate-specific antigen 665
focal adhesion kinase 528
alkaline phosphatase 512
urokinase-type plasminogen activator 372
luciferase 361
prostate-specific membrane antigen 264
lactate dehydrogenase 261
reverse transcriptase 261
protein kinase 250
MEK 249
collagenase 196
acid phosphatase 186
matrix metalloproteinase 2 153
MDP 152
peroxidase 147
CD10 144
APC 137
protein kinase C 130
caspase-3 127
MMP 124
tyrosinase 122
trypsin 104
thrombin 97
matrix metalloproteinase 9 95
plasmin 94
PARP 93
proteasome 90
gamma-glutamyl transpeptidase 89
thymidine kinase 87
catalase 86
ACS 86
P-glycoprotein 84
enolase 83
phosphatidylinositol 3-kinase 81
cathepsin D 77
cathepsin B 73
alanine aminotransferase 71
RNA polymerase 66
topoisomerase 66
topoisomerase 65
ATPase 64
thymidylate synthase 63
beta-galactosidase 59
MMP-3 59
succinate dehydrogenase 56
aspartate aminotransferase 53
neuraminidase 53
phosphoinositide 3-kinase 52
transcriptase 52
tissue plasminogen activator 49
hyaluronidase 49
lysozyme 48
hyaluronidase 45
AMP-activated protein kinase 42
dihydropyrimidine dehydrogenase 41
calcineurin 41
creatine kinase 41
glutathione S-transferase 40
superoxide dismutase 39
renin 39
aldehyde dehydrogenase 38
NOS 38
cdc2 38
GSK 37
RNase 37
carbonic anhydrase 36
aldehyde dehydrogenase 36
aldehyde dehydrogenase 36
RNase 36
aldehyde dehydrogenase 36
aldehyde dehydrogenase 36
lysyl oxidase 35
cathepsin K 35
DCF 34
lipoxygenase 34
MAP 34
firefly luciferase 33
thromboplastin 32
caspase-8 31
granzyme B 31
MAT 30
MAT 30
transglutaminase 28
ALDH 27
TACE 27
sialyltransferase 27
sialyltransferase 27
sialyltransferase 27
dihydropyrimidine dehydrogenase 26
thymidine phosphorylase 25
AMPK 25
lipase 25
MDR 24
caspase-9 24
cytosine deaminase 24
glyceraldehyde-3-phosphate dehydrogenase 24
cathepsin L 23
DNA methyltransferase 23
phosphoglucose isomerase 22
MIP 21
AMPK 21
interstitial collagenase 21
adenylate cyclase 21
phosphodiesterase 21
tyrosine hydroxylase 20
caspase-1 20
alcohol dehydrogenase 19
ACE 19
dihydrofolate reductase 19
STK11 19
chymotrypsin 18
CD13 18
ornithine decarboxylase 17
thyroid peroxidase 17
IKK 17
AST 17
PAL 17
ricin 16
glucose-6-phosphate dehydrogenase 16
ADH 16
kallikrein 16
pyruvate kinase 16
ceruloplasmin 16
arginase 16
PDK1 15
NO synthase 15
indoleamine 2,3-dioxygenase 15
ribonucleotide reductase 15
5'-nucleotidase 14
HDR 14
DNase 14
elastase 14
NADPH oxidase 14
phospholipase C 14
phospholipase A2 14
ribonucleotide reductase 13
dipeptidyl peptidase IV 13
NADPH oxidase 13
isocitrate dehydrogenase 13
MEKK1 13
DNA polymerase 13
ribonuclease 13
ribonuclease 13
tryptase 13
fumarase 13
TSA 12
demethylase 12
hexokinase 12
Thy1 12
isocitrate dehydrogenase 12
complex I 12
prostaglandin synthetase 12
endonuclease 12
pepsin 11
glutathione reductase 11
sialidase 11
CPT 11
adenosine deaminase 11
more...
Compound
Clin 10435
Dec 7224
DNA 3368
TNM 979
MDA 918
iodine 863
calcium 696
5-FU 624
oxygen 552
glucose 526
tyrosine 490
water 409
acetate 383
Thyroid 374
methionine 346
Adriamycin 344
His 299
fluorine 279
phosphate 272
sodium 271
galactose 259
DDP 246
nitric oxide 228
iron 217
TSH 215
sulfate 193
serine 192
DTPA 191
MEK 191
DIC 181
TNF 177
arginine 171
folinic acid 169
CPT-11 167
MTT 167
creatinine 165
BCG 164
Optimal 162
barium 162
CTX 159
ACTH 154
CAM 150
lysine 149
ATP 138
nitrogen 135
ethanol 134
DBA 133
PEG 131
leucine 129
Vimentin 127
MCA 125
MCA 124
Cardiol 122
SCC 121
ADR 120
Tamoxifen 120
Tamoxifen 117
MMC 116
Androgen 115
cysteine 113
VP-16 113
cobalt 112
A 71 111
zinc 111
retinoic acid 110
strontium 110
silver 110
CO2 108
ASA 105
DBA 103
DBA 103
formaldehyde 102
Methotrexate 101
Paclitaxel 100
Adrenal 99
Gemcitabine 97
Estrogen 97
Gemcitabine 97
Phe 94
threonine 93
hydrogen 90
urea 89
PEG 87
ACS 86
vitamin D 86
ACS 85
Docetaxel 84
GM1 82
Pac 81
potassium 80
Estrogen 79
hyaluronic acid 78
CBDCA 77
CBDCA 77
BCNU 74
Asp 74
BLM 74
DFS 73
Gly 71
cAMP 71
Interleukin-2 68
copper 67
CAP 65
MAP 64
PMA 61
alanine 59
ADP 59
phosphorus 56
PAS 55
FUDR 55
ADP 55
ADP 55
A 42 54
Leucovorin 53
Capecitabine 52
Luminal 52
MTC 52
A 3 52
NH2 52
CAT 52
CAT 51
PAP 51
PGE2 51
CAT 51
PAP 51
Neo 51
6-12 50
PAP 50
Octreotide 50
prostacyclin 50
PAP 50
pyrimidine 50
salt 50
pyrimidine 50
MTX 48
GTP 48
AMP 48
glutamate 47
CCC 47
CCNU 46
bromide 46
TPA 46
TPA 46
glutamine 45
GSH 45
GSH 45
acetic acid 45
aldosterone 43
SDS 43
Collagen 41
BEP 41
Calcitonin 40
COX 40
proline 40
tryptophan 39
Progesterone 39
Vincristine 38
PGE 37
Hematoxylin 37
GlcNAc 36
more...