Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We previously performed a global analysis of the gene expression of gastric cancer cell lines established from peritoneal dissemination (SNU-5, SNU-16, SNU-719, KATO-III and GT3TKB) with the cDNA microarray method to identify the novel markers for the detection of micro-metastasis in peritoneal cavity. One of the up-regulated genes is Reg IV, which is a member of the Reg gene family belonging to calcium dependent lectin (C-type lectin) gene superfamily. We have examined Reg IV potential as a novel marker for the detection of peritoneal micro-metastases of gastric cancer. Reg IV expression was examined in five gastric cancer cell lines established from peritoneal dissemination and compared with myeloid leukemia cell (HL60), methothelial cell lines Met5A and the other gastric cell line established from primary tumor (SNU-1) by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Reg IV was highly overexpressed in 4 gastric cancer cell lines established from peritoneal dissemination, but weakly expressed in other cell lines. According to Reg IV mRNA expression levels in surgically resected specimens, the quantity of Reg IV correlated with wall penetration. Furthermore, Reg IV mRNA expression level in the peritoneal wash from 35 gastric cancer patients was also prone to correlation with wall penetration. These results suggest that Reg IV may be involved in peritoneal dissemination of gastric cancers and Reg IV may be a potential novel marker for peritoneal dissemination of gastric cancers.
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PMID:[Over expression of Reg IV in peritoneal dissemination of gastric cancer]. 1555 56

The diagnosis and management of prostate cancer is hampered by the absence of markers capable of identifying patients with metastatic disease. In order to identify potential new markers for prostate cancer, we compared gene expression signatures of matched androgen-dependent and hormone refractory prostate cancer xenografts. One candidate gene overexpressed in a hormone refractory xenograft was homologous to the regenerating protein gene family, a group of secreted proteins expressed in the gastrointestinal tract and overexpressed in inflammatory bowel disease and cancer. This gene, Reg IV, was confirmed to be differentially expressed in the LAPC-9 hormone refractory xenograft. Consistent with its up-regulation in a hormone refractory xenograft, it is expressed in several prostate tumors after neoadjuvant hormone ablation therapy. As predicted by its sequence homology, it is secreted from transiently transfected cells. It is also expressed strongly in a majority of hormone refractory metastases represented on two high-density tissue microarrays. In comparison, it is not expressed by any normal prostate specimens and only at low levels in approximately 40% of primary tumors. These data support Reg IV as a candidate marker for hormone refractory metastatic prostate cancer.
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PMID:Reg IV: a promising marker of hormone refractory metastatic prostate cancer. 1578 72

We had performed a global analysis of the gene expression of gastric cancer cell lines established from malignant ascites to identify the novel markers for the detection of micro-metastasis in peritoneal cavity. One of the up-regulated genes is Reg IV, which is a member of the Reg gene family belonging to calcium dependent lectin (C-type lectin) gene superfamily. But the role of Reg IV in peritoneal dissemination is still unclear. We have examined the potential of Reg IV as a novel marker for the detection of peritoneal micro-metastases of gastric cancer. Reg IV expression was examined by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Mean Reg IV mRNA expression levels in surgically resected specimens (n = 41) were more than 20-times higher than those in normal mucosa from those patients. Furthermore, Reg IV mRNA expression level in the peritoneal wash was strongly higher in peritoneal metastasis compared to those without peritoneal metastasis. These results suggest that Reg IV may be involved in peritoneal dissemination of gastric cancers and Reg IV would be a potential novel marker for peritoneal dissemination of gastric cancers.
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PMID:[Analysis of Reg IV expression in peritoneal dissemination of gastric cancer using real-time RT-PCR]. 1631 15

Tumor metastasis is the leading cause of death in patients with advanced gastric cancer (GC). Limited therapeutic regimens are available for this condition, which is associated with a poor prognosis, and the mechanisms underlying tumor metastasis remain unclear. In the present study, increased histone methyltransferase G9A expression in GC tissues correlated with advanced stage and shorter overall survival, and in vitro and in vivo experiments revealed that G9A promoted tumor invasion and metastasis. Moreover, we observed that Reg IV induced G9A via the p-ERK/p-SP1 pathway. SP1 directly binds the G9A promoter and enhances G9A expression, and upregulated G9A then forms a transcriptional activator complex with P300 and GR, thereby promoting ITGB3 expression induced by dexamethasone (DEX) and contributing to GC metastasis. However, the G9A-mediated increase in ITGB3 expression was not dependent on the SET domain and methyltransferase activity of G9A. This study demonstrates that G9A is an independent prognostic marker and promotes metastasis in GC, thus suggesting that it may be a tumor biomarker and potential therapeutic target in GC.
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PMID:G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner. 2944 39