Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of epididymotesticular metastases are reported: one epididymal from a carcinoma of the kidney by retrograde venous spread and the other testicular secondary to a carcinoma of the prostate and apparently by arterial spread. Epididymotesticular metastases of carcinomas are rare. When the initial carcinoma is known, or even treated, the development of a large testis should lead to consideration of the possibility. Treatment should consist of inguinal orchidectomy with ligation of the spermatic cord as high as possible.
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PMID:[Epididymal and testicular metastases. 2 cases (author's transl)]. 49 14

Six monoclonal antibodies directed against ovarian adenocarcinoma were generated by use of 100,000 x g supernatants of Triton-X-100 solubilized extracts of ovarian serous adenocarcinoma as the antigen source. Immunoperoxidase preparation of frozen-sections and routinely processed paraffin section specimens revealed a highly restricted reactivity of these antibodies when tested with adult (n = 2) and fetal (n = 3) tissue types. Coreactivities were occasionally observed with epithelia of the kidney, mammary gland, and pancreas. One monoclonal antibody, Ki-OC I-6-2, cross-reacted only with epididymal epithelia. No coreaction occurred with normal tissue of the ovary, Fallopian tube, or uterus. All antibodies were additionally tested on 74 cases of nonovarian malignancies, 15 cases of ovarian metastases of nonovarian carcinomas, and 114 specimens of ovarian neoplasms other than carcinomas. Ki-OC I-6-2 had no cross-reactivity with these tumors except for one case of renal cell carcinoma. This monoclonal antibody recognized serous, mucinous, and poorly differentiated adenocarcinoma cell types. None of the six antibodies reacted with clear cell or endometrioid carcinoma. All were found to be of the IgG-1 subclass. The tumor antigen to which Ki-OC I-6-2 immunoreacted was estimated to have a molecular weight of 80 kilodaltons (KD).
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PMID:Six new monoclonal antibodies to serous, mucinous, and poorly differentiated ovarian adenocarcinomas. 217 66

We present a rare case of primary carcinoma of the left epididymis in a 32-year-old man. Pathological diagnosis was anaplastic carcinoma of epididymis. The patient is alive and free of metastases 2 years after orchidectomy. Clinical and pathological aspects of epididymal carcinomas are discussed with reference to previously reported cases.
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PMID:A case of primary carcinoma of the epididymis. 368 38

A case of adenocarcinoma of the stomach was initially diagnosed by detection of epididymal metastases. The case is presented and the importance of histologic examination of peroperatively removed tissue is emphasized.
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PMID:Metastatic tumour of the epididymis. A case report. 370 72

This is an up-to-date report about two patients suffering respectively from testicular and epididymal metastases of a renal adenocarcinoma in the condition following tumour nephrectomy in anamnesis. It is a survey on literature including the number of cases published.
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PMID:Intrascrotal metastases from renal cell carcinoma. 381 22

A patient with carcinoma of the colon developed metastases to the penis and right epididymis. These two organs are rare locations for metastases and the concurrent involvement of both sites has not been previously described. Our patient and the results of a literature review are presented. Two hundred eighteen cases of penile and 37 separate cases of epididymal metastases were identified. The genitourinary and gastrointestinal tracts were the predominant sites of the primary malignancies. Presenting symptoms, the interval between diagnoses of the primary and metastatic lesions, and the therapy of the penile/epididymal deposits varied greatly. Surgical excision is the major mode of therapy; radiotherapy, chemotherapy, or hormonal therapy may be beneficial in selected cases. Survival among these patients is poor due to the presence in most patients of widespread metastases in addition to their genital lesions. However, instances of prolonged survival are noted in both groups. Patient characteristics and possible mechanisms of metastatic spread to the genitals are discussed.
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PMID:Secondary malignancies of the penis and epididymis: a case report and review of the literature. 388 Aug 9

In a series of 24 patients with cerebellar haemangioblastoma two subsequently developed renal carcinoma and one was found to have an epididymal tumour. The association between renal carcinoma and cerebellar haemangioblastoma is discussed. Repeated investigation of the genitourinary tract is advised in all cases of cerebellar haemangioblastoma to detect renal carcinoma before metastases have developed.
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PMID:Cerebellar haemangioblastoma and genitourinary tumours. 485 86

This paper reports the effects of prolonged stilbestrol administration in ovariectomized female dogs and some observations on the effects of this hormone on a group of male dogs. It was shown previously that ovarian tumors, which frequently metastasise to serous surfaces, can be produced in dogs by prolonged administration of stilbestrol. Total amounts of stilbestrol given to individual dogs in this study ranged from 180 to 570 mg, mainly over a period of 48 weeks. The ability of non-ovarian serous surfaces to proliferate in response to stilbestrol, independently of ovarian metastases, was studied in 5 females and 4 males. Papillary proliferations occurred on the uterine serosae in 3 females and on the testicular and epididymal serosae in 2 males. In no case was there papillary proliferation on serous membranes of non-genital organs. One of 2 entire females given stilbestrol had proliferations regarded as metastases of ovarian origin on non-genital serous membrane. In addition to ovarian changes, stilbestrol can cause primary proliferative lesions in the serous membranes of certain genital organs in both sexes. There is no evidence that serous membranes of non-genital organs be capable of a primary proliferative response to stilbestrol.
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PMID:Proliferative lesions of serous membranes in ovariectomised female and entire male dogs after stilboestrol administration. 515 33

A case of bilateral epididymal metastases appearing sixteen years after nephrectomy for renal cell carcinoma is reported. A literature review of intrascrotal metastases from renal cancer reveals that they are uncommon. The possible mechanisms of spread are discussed.
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PMID:Late intrascrotal metastases from renal cell carcinoma. 675 56

We report 2 cases of rhabdomyosarcoma of the paratesticular tissues. Differentiation from chronic epididymal infection, such as tuberculosis, may be difficult but it must not delay operation. Lymphography is of limited value in delineating lymph node metastases. In both cases secondary spread was suggested but not confirmed histologically. Lymphography, because of a definite mortality rate of 0.1 per cent and morbidity rate of 1 per cent, would appear not to be indicated.
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PMID:Rhabdomyosarcoma of the paratesticular tissues. 728 56


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