Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This work is based on a review of 120 peripheral bone metastases of the upper limbs found in the literature and 10 others selected from a personal series of 469 cases of bone metastases. The authors stress the scarcity of these lesions (2%), metastases arising in bones of the forearm are usually part of a widespread osseous involvement, generally of mammary or prostatic origin. Metastases to the bones of the hand are more peculiar: 1) Those from bronchogenic carcinoma account for 50%. 2) Resultant soft tissue necrosis creates swelling, redness, heat and pain, which can mimic acute osteomyelitis. 3) X-rays reveal isolated osteolysis affecting metacarpals, phalanges, or more rarely carpal bones. Distal location of those metastases does not modify therapeutic management amputation is the best effective palliative treatment and must be discussed every time there is a concomitant skin ulceration, or if bone metastasis is unique or if the primary tumor is cured or accessible to treatment.
Sem Hop 1982 Dec 16
PMID:[Distal bone metastases of the upper limb]. 629 77

Five cases of chondrosarcoma are reported. Some specific characteristics of this tumor are recalled : prevalence is approximately 10% of primary malignant bone lesions, onset usually occurs between 40 and 70 years of age, prevalence is higher in males, elective sites are the proximal long bones and pelvis, pain is often the initial symptomatology, the patient's general condition remains satisfactory over a long period of time, sedimentation rates have no diagnostic or prognostic value, medullary arteriography and computed tomography are helpful for evaluation the topography and the extension of a vertebral localization, and the course is protracted. Prognosis is dependent on both the surgical possibilities and the characteristics of the tumor (site, size, histologic grade). Conversely to metastases which occur electively in grade III tumors, recurrences are not necessarily correlated with the histologic grade; they often occur in tumors whose localization precluded radical surgery and may be the occasion of development into a higher grade of malignancy. Inasmuch as it is feasible, carcinologic surgery is the only effective therapy; it carries hope for 10 year survival times in approximatley 70% of patients.
Sem Hop 1983 Mar 10
PMID:[5 cases of chondrosarcoma. Review of the literature]. 630 84

Chemotherapy is essential for the treatment of malignant diseases in childhood. Monitoring a child on chemotherapy includes: 1) looking for evidences of relapse or metastases; 2) if necessary, adjusting doses according to blood counts; 3) preventing and treating intercurrent infections, which are mostly viral, once the initial regimen is completed; 4) diagnosing and, if possible, treating, harmful side-effects, which cannot always be precluded; 5) helping both patient and family to live a normal life; in this respect, normal school attendance is of particular significance.
Sem Hop 1983 Mar 17
PMID:[Monitoring anticancerous and antileukemic chemotherapy in children]. 630 3

Fourteen adult patients with inoperable soft tissue sarcoma (with metastases in 4 cases) received chemotherapy as primary treatment. Nine cases were treated by CYVADIC (cyclophosphamide, vincristin, doxorubicin, DTIC) and five cases by DECAV (DTIC, cyclophosphamide, cis-platinum, doxorubicin, vindesine). An objective response was obtained in 7 cases (1 complete remission and 6 regressions greater than 50%) and stabilization in 4 cases. Seven patients became operable after 2 to 6 courses of chemotherapy and a complete resection could be performed in 6 cases. The duration of the response was 2 to 39 months. Toxicity with both combinations was acceptable. We conclude that chemotherapy can provide initial tumor reduction and permit subsequently less radical surgery.
Sem Hop 1983 May 12
PMID:[Primary chemotherapy in soft tissue sarcomas considered inoperable]. 631 Jul 58

From a series of 50 thyroid cancers with lymph node metastases, the authors have conducted a topographical study of lymph node dissemination in the neck according to the topography of the primary cancer and its anatomopathological form. The prognostic aspects drawn from this casuistic study concern the anatomopathological form, the type of lymph node extension in the neck, and the type of lymph node dissection carried out for curative purposes. This study's main findings are that the anatomopathological element predominates over lymph node dissemination, and that conservative lymph node removal remains preferable to the classical total excision.
Sem Hop 1983 May 26
PMID:[Lymph node involvement in 50 cases of thyroid cancer. Topographic and prognostic study]. 631 Jul 73

Clinical and pathological findings in a forty-eight-year-old woman with malignant mesenchymatous hamartoma of the liver (embryonic sarcoma) are reported. Special emphasis is put on the monomorphic leiomyosarcomatous aspect of the peritoneal metastases, and on the presence of pseudo-tumorous foci abounding in plasmocytes and centered by recent phlebitis.
Sem Hop 1983 May 26
PMID:[Malignant mesenchymatous hamartoma of the liver in adults. Apropos of a case]. 631 Jul 77

Two cases of spinal subarachnoidal metastases are reported. From data from the literature, the authors review clinical manifestations and diagnostic difficulties. Etiopathological evidence which may explain this localization is discussed.
Sem Hop 1983 Sep 22
PMID:[Subarachnoid spinal metastases. Apropos of 2 cases]. 631 4

Diagnosis is suggested by the functional symptoms and digital rectal examination and must be confirmed by histological examination. The second step is to evaluate the patient's condition, the extent of the cancer and the consequences on the urinary system; the choice of the treatment depends on this evaluation. The most common tumors are adenocarcinomas with a histological grading strongly correlated to the lymphatic involvement and frequency of metastases. Lymphatic involvement is closely related to the local clinically demonstrable involvement, histological grade, serum acid phosphatase concentrations and results of lymphography. Upon diagnosis of cancer of the prostate more than half the patients already harbour metastases, usually of the bone. This percentage is correlated to the size of the primary tumor, involvement of the seminal vesicles, histological grade and lymphatic involvement. The authors propose a series of investigations adapted to each case.
Sem Hop 1983 Oct 13
PMID:[Diagnosis and evaluation of the extent of cancer of the prostate]. 631 15

Twenty-six patients with known primary tumors were treated surgically for pulmonary metastases between 1951 and 1979. The metastases were diagnosed more often (58% of cases) by routine radiological examinations than because of thoracic symptoms. While diagnosis of the primary tumor and the metastases was simultaneous in three cases, the average lapse of time between the two diagnoses was 5 years and 1 month in the other cases. In four cases, it was 10 years or more. Lung X-rays showed single tumors more often than multiple tumors (12%). Broncho-fibroscopy was usually normal, but a preoperative biopsy showed the metastatic nature of the tumor in 5 cases. Ablation was by lobectomy (42%), pneumonectomy (23%) or atypical resection (27%). The hospital mortality rate was 7.6%. The survival rate at 1, 3 and 5 years (71%, 39%, and 17%) is identical to that of primitive bronchial tumors, and seems to be influenced by certain factors, such as the locus of the primitive tumor (with a particularly bad prognosis for ENT tumors), the lapse of time between the diagnoses of the primary and secondary tumors, the fact that there is one, rather than several, metastases, or that the metastases are monolateral rather than bilateral, and, finally, the limited nature of the exeresis. These factors prompt regular, systematic and prolonged radiological monitoring in search of further pulmonary metastases.
Sem Hop 1983 Nov 24
PMID:[Surgical treatment of pulmonary metastases. Apropos of 26 cases]. 632 Mar 80

The aim of this study is to determine the value of serum ferritin assay alone or combined with CEA and beta-2-M. For the diagnosis of breast cancer, serum ferritin is of little value, with 23% false positive and 41% false negative results. Furthermore, combination with CEA and beta-2-M assays does not improve the diagnosis of malignancy. However, mean ferritin concentrations and percentage of positive results increase with tumor volume, number of involved lymph nodes, distant metastases, and exacerbations. During follow up, variations in serum ferritin concentrations parallel clinical course in 77% of patients, as compared to 62% for the three proteins. Ferritin can be involved in biological exchange processes. Association with hepatic, hematological or inflammatory disorders must therefore be considered in interpreting an increase in serum ferritin in cancer patients.
Sem Hop 1984 Jan 26
PMID:[What value should be given to assays of serum ferritin in breast cancers? Correlation with various biological parameters]. 632 Apr 39


<< Previous 1 2 3 4 5 6 Next >>