Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The intravenous injection of high molecular dextran (HMD), increased pulmonary metastases of the carcinosarcoma of Walker 256, from 35 per-cent of the control animals to 64 per-cent of the animals treated with HMD. A significant prolongation of the clotting time and prothrombin; and a decrease in fibrinogen levels platelets, hematocrit and factors II, V, VII and VIII were observed following the infusion of HMD. There was no obvious untoward side effect of HMD in any of the animals studies.
 ...
PMID:The effect of high molecular dextran on coagulation and metastes. 101 21

Reported in this paper are two cases of aggressive perineovulvar angiomyxoma. Soft, painless tumours with gelatinous cut surface were detected in either patient, two women aged 32 and 46 years. Histological findings included fibromyxoid stroma with spindle-shaped and stellate cells as well as vascularization in striking abundance. Most of the vessels were thin-walled. There was no plexiform arborization. Strongly atypical nuclei or mitoses or necrotic foci were not recordable. The tumour exhibited infiltrative growth. Tumour cells could be immunohistochemically associated with antibodies against vimentin, whereas negative responses were recorded from antibodies against S-100 protein, factor-VIII-associated protein and pancytokeratin. Aggressive angiomyxoma is a biologically benign neoplasia prone to recurrence and typically localized in soft tissue of the pelvic region. Metastases so far have never been found. Wide local excision has proved to be the optional therapeutic approach.
 ...
PMID:[Aggressive angiomyxoma of the vulva and perineum]. 142 Jan 11

A total of 659 freshly diagnosed nasopharyngeal carcinoma (NPC) (1984-1987), were investigated by computed tomography (CT), treated with locoregional radiotherapy to radical dose, and given neoadjuvant chemotherapy (CHEMO) with 2-3 courses of cisplatinum and 5-fluorouracil for bulky (greater than or equal to 4 cm) cervical nodal metastasis and booster radiotherapy (PPB) for parapharyngeal disease. All except 15 patients were fully evaluable with complete data entry till death or to the last follow-up (minimum 2 years). The data have been analysed extensively to identify variables of potential prognostic significance. The assessed factors include patients' sex and age, nasal involvement (NAS), oropharyngeal involvement (ORO), parapharyngeal involvement (PAR), muscle involvement (MU), skull base involvement (BS), cranial nerves (II-VIII) palsy (CN1), cranial nerves (IX-XII) palsy (CN2), intracranial extension (IC), laryngopharyngeal extension (HYP), confinement to nasopharynx (NP), Ho's N-stage (Nho), maximal nodal size (Nmax), nodal mobility (Nf- fixed, Npf- doubt in mobility, Nm- mobile), nodal laterality (unilateral, contralateral, bilateral), nodal multiplicity (single, multiple), and presentation with distant metastasis (M1). These factors have been assessed as to their interdependence and correlation with the clinical course (study endpoints) using both monovariate analyses and Cox's Regression model. Significant association among Ho's T2 and T3 features was identified. Advanced Ho's N-stage correlated significantly with bulky nodes, multiple nodes, fixed nodes, and, contralateral and bilateral nodes. Poor prognostic factors found to be significant by both monovariate analyses and Cox's Regression model included the M1, Nho (advanced), CN1, BS, and CN2 for the actuarial survival (ASR) for all patients (659), the Nho (advanced), CN1, CN2, and BS for the ASR for the non-metastatic patients (628), the absence of NP and the male sex for the local failure rate (628), the Nho (advanced), CN2, and BS for the distant metastasis rate (628), and the Nho (advanced), CN1, and BS for the disease-free survival (DFS) (628). In addition, old age, male sex, and the presence of parapharyngeal disease were probably significant in predicting poor survival (ASR); CN1 was probably significant in predicting more local failures, and, the parapharyngeal disease and the intracranial extension for more distant metastases. The Ho's N-staging is superior to the other N-stage classifications, because once the Ho's N-stage has been determined, other nodal characteristics including nodal size, multiplicity, laterality, and fixity, are prognostically insignificant.
 ...
PMID:Prognostic factors in nasopharyngeal carcinoma investigated by computer tomography--an analysis of 659 patients. 147 Jun 99

The authors review the clinical, radiological and pathological features of 6 cases of glomus tumors of the temporal bone. Out of the 6 patients, 5 were female; age was distributed between 22 and 76 years (mean 48 years). The main clinical features were hypoacusia, tinnitus and otoscopic findings suggestive of the diagnosis. In one case was noted the concomitant presence of a neurinoma of the VIII cranial nerve with a ipsilateral glomus tumor, and in another case there was a concomitancy of carotid body tumor with temporal glomus jugularis tumor. Metastases were not observed in any case. Tumoral lesions were successfully ressected employing microsurgical techniques and a multidisciplinary staff involving neurosurgeons, head and neck surgeons and otolaryngologists. Radioteraphy was not employed, neither pre-operative embolization. Some aspects related to the nosology, embriology, pathophysiology, diagnosis and treatment of this interesting type of neoplasms are discussed.
 ...
PMID:[Glomus tumors of the temporal bone: a report of 6 cases]. 254 64

An 80-year-old man was seen in the clinic with a two month history of pain, bleeding and deafness in his left ear; accompanied by a left facial palsy. Six months earlier, anaplastic carcinoma of the bladder had been diagnosed and treated with radiotherapy. On examination there was a mass in his left external auditory canal and VII, VIII, IX and X left cranial nerve palsies. Histology of a biopsy was identical with his original bladder tumour. He received a course of palliative radiotherapy but died shortly after. Post-mortem demonstrated the left temporal bone metastasis extending into the middle and posterior cranial fossae. There was no evidence of residual bladder tumour, or other primary tumour. Temporal bone metastases are probably more common than generally thought. Presentations like this may become more common as cancer therapy improves, with patients surviving longer and presenting later with metastatic disease.
 ...
PMID:Metastasis to the temporal bone, secondary to carcinoma of the bladder. 276 28

Cutaneous angiosarcoma are rare tumours and occur particularly rarely on the extremities. There are only a few reports in the literature concerning their clinical and catamnestic behaviour. We report the case of a 57-year-old male North African with a large exophytic and nodular tumour of the left forearm that showed a vasoformative histological pattern. The endothelial cell origin was proven by immunocytochemistry using endothelial cell antibodies such as anti-vWf (syn.:anti F VIII R:Ag), UEA I and the monoclonal antibody BMA 120. The patient's history revealed that the neoplasm had grown slowly for more than 15 years. After partial resection, the tumour enlarged rapidly and the patient died of widespread metastases.
 ...
PMID:[Cutaneous metastatic angiosarcoma of the forearm]. 306 96

The problem of the differential diagnosis both of central nervous system haemangioblastomas and metastases of renal clear cell carcinomas was investigated by immunoperoxidase labelled antibody staining of five cases each of haemangioblastoma and metastatic renal carcinoma. Staining using anticarcinoembryonic antigen (CEA), antikeratin, antifactor VIII related antigen, and antibrush border was unhelpful. All five of the haemangioblastomas were negative and all five of the metastases were positive for epithelial membrane antigen (EMA), as defined by immunoperoxidase staining. This shows that commercially available anti-EMA monoclonal antibody is useful in distinguishing the two pathological entities.
 ...
PMID:Immunoperoxidase labelled antibody staining in differential diagnosis of central nervous system haemangioblastomas and central nervous system metastases of renal carcinomas. 352 31

Between 1969-1984 (16 years) 17 patients with "malignant haemangioendothelioma" of the thyroid were admitted to our services. This type of cancer is usually found in patients with a long history of goiter and is a very aggressive tumor. Infiltration of surrounding tissues is mostly responsible for death by asphyxia or uncontrollable bleeding. Some patients die also from metastases, which were seen frequently in the lungs. A precise preoperative diagnosis of the disease can be achieved rarely, histological classification has improved using immunohistochemical assays of Factor-VIII antigen in tumor tissue. No "prescription" for therapy can be given: results of surgery, radiotherapy and chemotherapy do not show significant differences (also in a variety of combinations). If the diagnosis is properly established, palliation will be the only therapeutic goal.
 ...
PMID:[Malignant hemangioendothelioma of the thyroid gland]. 374 89

Epithelioid hemangioendothelioma (EH) is a vascular neoplasm that occurs predominantly in soft tissue and is not infrequently misdiagnosed as an epithelial neoplasm or angiosarcoma. Only a few cases of hepatic EH have been described, and a relationship to oral contraceptive (OC) use in patients with the hepatic lesions has not generally been recognized. We present a series of five patients with malignant epithelioid hemangioendothelioma of the liver. Confirmation of the endothelial origin of these tumors was provided by positive immunoperoxidase staining for Factor-VIII-related antigen in the four cases studied by that technique, and by the demonstration of Weibel-Palade bodies in two tumors examined by electron microscopy. All five patients were young women (mean age 33 years) and all five gave a history of OC use of 4-7 years' duration. The clinical course varied from indolent but progressive to rapid death. One patient who underwent resection of the primary tumor has survived 3 years without evidence of disease, and one patient with metastatic disease who was treated with radiation and chemotherapy has survived for 8 years with disease. Three patients with extrahepatic spread have died of the tumor. Early diagnosis of this distinctive tumor might offer the hope of salvage by resection or liver transplantation.
 ...
PMID:Malignant epithelioid hemangioendothelioma of the liver in young women. Relationship to oral contraceptive use. 390 92

Six cases of Ewing's sarcoma were investigated by electron and immunofluorescence microscopy. A layer of basement membrane-like deposits was found between typical principal and secondary tumor cells. To clarify the nature of these ultrastructural deposits, antibodies against collagen type IV were applied to frozen sections of corresponding tumor tissue. This reaction revealed type IV collagen as a regular component of basement membranes in nonneoplastic tumor capillaries, but it was equally able to localize collagen type IV between single tumor cells in capillary-free areas. With the same method, factor-VIII-associated protein, predominantly found in endothelial cells, could be demonstrated in some tumor cells. These results demonstrate that, in addition to anaplastic cells, some tumor cells are found in Ewing's sarcoma that share certain differentiating features with the endothelial cell.
 ...
PMID:Biologic characterization of human bone tumors. I. Ewing's sarcoma. A comparative electron and immunofluorescence microscopic study. 681 37


1 2 3 4 5 Next >>