Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antitumor agents can inhibit tumor growth by 4 major cellular mechanisms; suppressing proliferation, inducing differentiation, killing the cells or forcing them to senescence. Senescent cells (CS) are in permanent paralysis because they are unable to divide, penetrate the surrounding tissues, metastasize, and respond to treatment. In this short review, we will focus on cellular senescence (CS) induced by retinoids in mammary pre-malignant and tumor cells and its potential clinical implication. Novel information is provided about the role of retinoic acid receptor beta 5 (RARbeta5) in mediating the retinoid-induced senescent program.
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PMID:To kill tumor cells or permanently paralyze them in senescence? 1965 Jan 65