Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Molecular genetic studies of C. elegans vulval development have helped to define an evolutionarily conserved signaling pathway from an EGF-like ligand through EGF-receptor, Ras and MAP kinase to the nucleus. Further studies have identified novel positive regulators such as KSR-1 and
SUR-8
/
SOC-2
and negative regulators such as cbl/SLI-1. The many negative regulatory proteins might serve to prevent inappropriate signaling, and thus are analogous to tumor suppressor genes.
Cancer
Metastasis
Rev 1999
PMID:C. elegans vulval development as a model system to study the cancer biology of EGFR signaling. 1072 84
