Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The International Society of Paediatric Oncology (S.I.O.P.) organised a study and trial on nephroblastomas in September 1971. This first trial was stopped in October 1974. In this period, 398 patients were included in trial and study. Patients came from 42 Centres in 14 countries. Eligible for the clinical trial were 195 patients. The clinical trial consisted of 2 parts: Part 1. Radiotherapy: Pre- and post-operative radiotherapy versus post-operative radiotherapy alone. Part 2. Chemotherapy: One single course of actinomycin D versus multiple courses of actinomycin D. For the radiotherapy trial, 137 cases were suitable after randomization. Concerning the recurrence-free survival, there were no significant differences following the actuarial statistical method. The same for survival. There was a high rate of ruptures in the post-operative group. These ruptured cases caused a higher rate of metastases and asked for a heavier treatment. Especially because of these ruptured cases the conclusion is drawn that pre- and post-operative radiotherapy is a better way of treatment for nephroblastomas when they cannot be expected to be a stage I tumour on clinical grounds. For the chemotherapy trial, 160 cases were suitable. There was no difference between the group of patients receiving a single course versus multiple courses of actinomycin D. Disease-free interval and survival in both groups in all stages were the same. The conclusion is drawn that this way of treatmetn does not make any difference. In a second study, chemotherapy with two agents is considered in two groups of patients receiving 6 months chemotherapy vincristine and actinomycin D versus 15 months.
An Esp Pediatr 1976 Dec
PMID:Trial and study on nephroblastomas S.I.O.P. No. 1. 18 55

The authors describe a new case of mandibular metastasis of a hepatome. They recall that these metastases indicate tumour and that they are generally haemorrhagic. Diagnosis is confirmed by means of biopsy, but the scanner or echotomography and angiography reveal the primary lesion. Investigation using marked technetium pyrophosphate is essential to screen for further osseous lesions.
Rev Stomatol Chir Maxillofac 1976 Dec
PMID:[Mandibular metastasis disclosing a primary cancer of the liver]. 19 Jun 69

Plasma hCT levels were less than 50 pg/ml in 50 normal subjects. In 16 patients with medullary carcinoma of the thyroid (MCT), plasma hCT levels were distinctively elevated and they fell significantly after total thyroidectomy, but in 11 of them plasma levels were still high, indicating the presence of metastases. In 74 patients with the other types of malignancy, plasma hCT levels were found to be high in 9 cases (3 oat cell carcinoma of the lung, 4 malignant carcinoids, one malignant pheochromocytoma and one acute myelocytic leukemia). Except for the leukemic case, all these tumors were derived from neural crest. In 12 patients with primary hyperparathyroidism, plasma hCT levels were less than 20 pg/ml. In 13 hypoparathyroid patients, two with pseudohypoparathyroidism and one with pseudoidiopathic hypoparathyroidism, plasma hCT levels were slightly elevated. Some patients with uremia had elevated plasma hCT levels, but there was no relation between plasma levels of hCT and those of PTH, urea nitrogen or creatinine. In response to Ca (4.5 mg/kg/10 min) or tetragastrin (4 mug/kg/5 min) infusion, a marked increase in plasma hCT was observed in all patients with MCT, but not in normal subjects. In 5 hypoparathyroid patients, a significant increase to both stimuli was also observed in all cases. Two patients with pseudopseudohypoparathyroidism responded to the Ca load. These results indicate that the determination of plasma hCT levels especially after a short Ca or tetragastrin infusion is important to study various pathological conditions.
Endocrinol Jpn 1976 Dec
PMID:Plasma human calcitonin (hCT) levels in normal and pathologic conditions, and their responses to short calcium or tetragastrin infusion. 19 Dec 50

A freeze dried preparation of BCG with a low ratio of living to dead organisms (LV) was compared to a frozen liquid preparation with high viability (HV) for its ability to eradicate established dermal tumors and microscopic lymph node metastases in guinea pigs. The cure rate achieved by the intralesional injection of LV-BCG did not differ significantly from that of HV-bcg when similar numbers of viable organisms were injected.
Cancer 1977 Dec
PMID:Immunotherapy of a guinea pig hepatoma with living BCG: a frozen liquid and a lyophilized preparation are equally active. 20 59

Two cases of endocrine inactive malignant islet cell tumors diagnosed by angiography are presented. The angiographic features are described and the differential diagnosis of the tumor and its metastases are discussed. Radiological literature of the past decade on this subject is reviewed.
Rofo 1977 Dec
PMID:Non-functioning islet cell tumours of the pancreas: a review of radiological literature and a report on two cases. 20 49

Eighty-five patients with a diagnosis of minimal breast cancer were evaluated. The predominant lesion was intraductal carcinoma, and axillary metastases occurred in association with minimal breast cancer in seven of 96 cases. One death occurred due to minimal breast cancer. Bilateral mammary carcinoma was evident in 24% and bilateral minimal breast cancer in 13% of the patients. The component lesions of minimal breast cancer have varied biologic activity, but prognosis is good with a variety of operations. The multifocal nature of minimal breast cancer and the potential for metastases should be recognized. Therapy should include removal of the entire mammary parenchyma and low axillary nodes. The high incidence of bilateral malignancy supports elective contralateral biopsy at the time of therapy for minimal breast cancer.
Ann Surg 1977 Dec
PMID:Minimal breast cancer: a clinical appraisal. 20 33

Telangiectasia-associated hepatic fibrosis (TAHF) in a 68-year-old woman with hereditary haemorrhagic telangiectasia (HHT) is described. The patient died of oat-cell carcinoma of the lung. In addition to the structural alterations which have been described previously in HHT, the liver exhibited focal midlobular hepatocytic necrosis and tumour metastases. The possibility that treatment of HHT was causally related to some of the hepatic abnormalities found in our patient and the differentiation of TAHF from true cirrhosis are discussed.
J Clin Pathol 1977 Dec
PMID:'Pseudocirrhosis' in hereditary haemorrhagic telangiectasia. 20 9

A series of halogenated compounds was tested by oral intubation in 200 Osborne-Mendel rats and 200 B6C3F1 mice of both sexes. Carbon tetrachloride, used as a positive control, induced liver and adrenal tumors in mice and neoplastic nodules in the livers of rats. 1,2-Dibromoethane and 1,2-dibromo-3-chloropropane caused stomach tumors with many metastases in both rats and mice. Chloroform, known to cause hepatocellular carcinomas in mice, led in addition to kidney tumors in male rats. 1,2-Dichloroethane was much weaker than the analog, 1,2-dibromoethane, and induced only a few stomach tumors in rats. It increased liver and lung tumors in mice. Most of the compounds, namely, trichloroethylene, 1,1-dichloroethane, 1,1,2-trichloroethane, hexachloroethane, and tetrachloroethylene, increased hepatocellular carcinomas in mice but had little or no action in rats. Iodoform tended to increase thyroid tumors in male rats and hepatocellular carcinomas in male mice. The action of 3-chloropropene was questionable. No tumors could be attributed to 1,1,1-trichloroethane (methyl-chloroform).
Environ Health Perspect 1977 Dec
PMID:Carcinogenicity studies on halogenated hydrocarbons. 20 28

The results of surgical treatment in 470 patients with carcinoma of the lung were analyzed by stage of disease and by histologic cell type. The need for accurate staging in selecting treatment and in prognosis for survival is emphasized. Surgical resection improved survival time in all categories of patients by effective local control of the lesion. The over-all five year survival rate was 14 per cent. Early stages of carcinoma of the lung were more amenable to surgical cure. The highest five year survival rate was 43 per cent and was observed in resected Stage I carcinomas. Only 29 per cent of this group died of the disease and 28 per cent, of other causes. The continued high incidence of death due to distant metastases underlines the necessity of combining operation with other forms of treatment.
Surg Gynecol Obstet 1978 Dec
PMID:Results of surgical treatment of carcinoma of the lung by stage and cell type. 21 53

The case of primary oat-cell carcinom of the larynx with metastases in the thyreoid gland and paratracheal lymphnodes is reported on. The different methods of treatment are examined, used examples of the much more common oat-cell carcinoma of the lung. The applicability of the methods to oat-cell carcinoma of the larynx is discussed. Our treatment scheme of surgery and extended radiation is used if the tumor is known to be locally restricted.
Laryngol Rhinol Otol (Stuttg) 1978 Dec
PMID:[Therapy of primary oat-cell carcinoma of the larynx (author's transl)]. 21 59


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