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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The treatment results of the Rotterdam working group on esophageal cancer during the period January 1970-January 1978 were assessed. A total number of 328 patients were treated: 230 males and 98 females. Of the 133 patients eligible for a combined treatment modality i.e. preoperative radiotherapy and surgery, 52 showed irresectable or metastatic disease during operation. The five year actuarial survival rate of the 81 patients, in whom curative surgical resection of the tumor was performed, amounted to 21%. Females fared better than males, the five year survivals being 42% and 12% respectively. This female preponderance in survival is partly explained by the considerable postoperative mortality of the male patients: 28% vs 7.4% in females. Patients who received only radiation therapy, whether curative or palliative, had a very bad prognosis. It is concluded that preoperative irradiation followed by surgical removal of the tumor should be performed in all operable-curable patients.
Ann Surg 1979 Dec
PMID:Carcinoma of the esophagus: results of treatment. 9 16

Disappointing results of radical mastectomy for treatment of inflammatory breast carcinoma led to its abandonment and the use of alternative therapeutic methods without improvement of survival rates. Results of radical mastectomy combined with other therapeutic modalities have not been fully evaluated so far. In a series of nine patients with proven inflammatory breast carcinoma and no distant metastases, two underwent radiotherapy, oophorectomy, and adrenalectomy (group A) and seven underwent preoperative irradiation, radical mastectomy, postoperative irradiation, and chemotherapy (group B). There were no local recurrences in either group. Group A patients survived five and eight months (mean, 6.6+/-2.1) and patients of group B survived 45.5+/-26.2 months (p less than 0.05). Results show no rational basis for withholding radical mastectomy, but suggest that improved survival may be obtained when radical mastectomy is an integral part of a rational sequential therapeutic schedule.
Am J Surg 1978 Dec
PMID:Inflammatory carcinoma of the breast. A therapeutic approach followed by improved survival. 10 13

The histological distribution of receptors for Ricinus communis Fraction 1 (RCA1) in oral carcinomas and in oral epithelial cells during wound healing has been studied by use of fluorescein-tagged RCA1. Biopsies from 15 human oral carcinomas and adjacent normal mucosa showed RCA1 receptors at the cell membranes in the basal and spinous layer of the normal epithelium, whereas receptors could not be demonstrated in invading islands of the tumors. In healing oral wounds from eight humans and three monkeys, RCA1 receptors were demonstrated both in normal epithelium adjacent to the wounds and in the epithelial outgrowth from the wound margin. Titrations, however, showed that the epithelial outgrowth reacted more weakly than did the normal adjacent epithelium. These results support previous in vitro studies showing changes in carbohydrate composition of moving normal cells and of malignant cells, a finding that may be of interest in relation to formation of metastases.
Cancer Res 1978 Dec
PMID:Expression of Ricinus communis receptors on epithelial cells in oral carcinomas and oral wounds. 10 24

Nineteen postmenopausal patients with metastatic breast cancer refractory to conventional combination chemotherapy were treated with monthly cycles with the combinations of vinblastine, adriamycin, thiotepa and halotestin. Ten patients (52%) responded with a greater than 50% regression of measurable tumor. The median duration of response was 11.5 months, with 5/10 patients still responding at a mean follow-up of 10 months. Only 2/10 responders have died with a mean follow-up of 13.8 months. In contrast, 8/9 nonresponders have died (median survival 6.0 months). Response to therapy was neither influenced by site of disease, time interval from diagnosis to primary chemotherapy nor duration of response to primary chemotherapy. No patient was hospitalized because of drug induced toxicity. This combination of drugs is a tolerable effective regimen for patients relapsing after adjuvant chemotherapy or after primary combination chemotherapy for grossly metastatic disease.
Cancer 1978 Dec
PMID:Vinblastine, adriamycin, thiotepa, and halotestin (VATH): therapy for advanced breast cancer refractory to prior chemotherapy. 10 10

In the presence of a solid intrarenal mass, ultrasound scans should not be limited to the mass itself. Modern commercial gray scale equipment is capable of demonstrating both tumor extension into the inferior vena cava and the metastatic disease to the liver. The presence of multiple solid intrarenal masses favors the diagnosis of metastatic disease to the kidney or multiple angiomyolipomas. Retroperitoneal lymphadenopathy or an adrenal mass coincidental with an intrarenal mass suggests metastatic disease. These possibilities can be detected by echography if prone scans are performed over the suprarenal region and the contralateral kidney, and supine scans are performed for evaluation of the inferior vena cava, liver, and retroperitoneum.
J Clin Ultrasound 1978 Dec
PMID:The complete echographic evaluation of solid renal masses. 10 19

Thoracoabdominal computed tomography (CT) scanning was performed prior to treatment on 30 patients with proven carcinoma of the esophagus. Operative, bronchoscopic, and/or autopsy data were reviewed and showed that CT correctly identified the extent of medistinal spread in 27 patients and intraabdominal metastases in 22 patients. The ability of CT to reliably predict the extent of disease should help the surgeon and radiation oncologist plan optimal therapy.
AJR Am J Roentgenol 1979 Dec
PMID:CT of the esophagus. II. Carcinoma. 11 94

On the basis of 110 prostatic osteoses that were histologically proven, constantly painful and demonstrated by X-ray, treated by early estrogenotherapy using very high doses, backed up by a high-dose maintenance estrogenotherapy, the authors study the clinical, radiological, histological and biological profile of this metastatic cancer, as well as the response to treatment. The median actuarial survival time of the patients studied is 18.5 months. No statistically significant prognostic correlation was found. Only patients who are clinically estrogen-sensitive, are suffering from bone metastases without a combined visceral conditions, and have a normal initial rate of alcaline phosphates, tend to have a better prognosis (median actuarial survival 31 months versus 18.5 months for the overall population).
Rev Rhum Mal Osteoartic 1979 Dec
PMID:[Prostatic osteosis. Retrospective study of 110 cases treated with high-dose estrogens]. 11 98

Intercellular glycosaminoglycans (GAGs) from various tissues were analyzed by cellulose acetate electrophoresis and enzymatic treatment with specific mucopolysaccharidases. Each tissue exhibits a particular composition of sulfate and unsulfated molecular species. Invariably, malignant human neoplasias and their metastases show striking variations in the electrophoretic pattern typical of the corresponding normal tissue. An absolute or relative increase in surface ChS A/C and HA seems to be a consistent feature of neoplastic transformation. On the other hand, the GAGs composition of benign noninfiltrative tumors does not vary greatly with respect to the original normal tissue.
Tumori 1979 Dec 31
PMID:Intercellular glycosaminoglycans in human cancer. 12 Jun 29

A 5 years survival of 20% without local recurrence and/or metastasis was obtained after radiation therapy alone. This figure is slightly inferior to the survival rate of surgically treated tumours. Failure is mostly due to the appearance of metastases after radical treatment in spite of additional chemotherapy and/or immunotherapy. But experience has also shown that certain cancers "locally controlled" by radiation therapy can recur 3, 5, 8 or even more years later. Two thirds of squamous cell carcinomas are sterilized with doses of 60 Gy. A dose of 80-90 Gy has a greater curative effect on tumours usually unresponsive to doses of 60 Gy. But this level of radiation results in significant damage to normal tissue with inacceptable complications. Even with such doses, quiescent cells and hypoxic cells remain unresponsive. These cell populations are both clonogenic later. Megavoltage therapy must therefore be associated with chemical and physical radiosensitizing agents (e. g. hyperthermia and drugs of the nitro-imidazole group). Treatment protocols also fully exploit the biological effect of chemotherapy recruitment, cell synchronisation and synergistic lethal effect. The biological effects to neutrons on hypoxic cells were also explored, as most of the latter respond to neither X nor kappa therapy. In all, the new treatment strategy must seek the complementarity of the specific biological effects or radiotherapy chemotherapy and radiosensitizing agents (chemical and/or physical). The goal is a 10% growth rate in the cure of squamous cell carcinomas.
Rev Fr Mal Respir 1979 Dec
PMID:[The use of potentiating agents in megavoltage therapy of non-resected localized carcinoma of the lung (author's transl)]. 12 19

In 156 patients the dynamic liver perfusion study with 99mTc-sulfur colloid and the scintillation camera was performed. Out of the 81 cases with confirmed diagnosis, the rapid sequential liver study was only in one case to provide an additional information of clinical importance, which could not be demonstrated by static liver imaging. Except for 2 patients with carcinoid metastases of the liver and 3 cases of acute hepatitis, we did not find any significant difference in the activity appearance in the liver between normal subjects and patients with liver metastases and diffuse liver diseases.
Rofo 1975 Dec
PMID:[The radionuclide hepato-angiography in the clinical diagnosis (author's transl)]. 12 7


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