Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary bony lymphomas are rare, and nearly all are high-grade B-cell lymphomas. Natural killer (NK)/T-cell lymphomas are highly aggressive lymphomas of NK- or T-cell lineage with predominant extranodal presentation and are divided into nasal and nasal-type (extra-nasal). We report a primary bony peripheral T-cell lymphoma mimicking NK/T-cell lymphoma, nasal type. A 22-year-old Taiwanese male presented with a frontal skull bone mass noted for 3 weeks, and received craniectomy with tumor removal. His tumor showed extensive coagulative necrosis with angioinvasion by large lymphoma cells expressing CD2, CD8, CD16, CD43, CD45, CD45RO, CD56, T-cell intracellular antigen-1, and granzyme B, but not CD3, CD4, CD20, CD57, CD68, and betaF1. In situ hybridization for Epstein-Barr virus-encoded mRNA was negative. Polymerase chain reaction study of formalin-fixed tissue showed clonal rearrangement of the T-cell receptor-gamma chain gene. The diagnosis was peripheral T-cell lymphoma, unspecified subtype. The initial stage was I(EA). His lymphoma was refractory to chemotherapy, and bony metastases developed in the right iliac bone 2 months later. He died of disease after 6 months without autopsy. We emphasize the importance of detailed immunohistochemical and gene rearrangement studies for the classification of malignant lymphomas via a very rare primary bony lymphoma of peripheral T-cell subtype.
 ...
PMID:Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report. 1209 74

A quantification of peripheral blood CD2, CD3, CD4, CD8 i CDDR positive cells was performed to evaluate effectiveness of a bovine thymic extract, TFX-thymomodulin in expresing those surface markers, modulated by postoperative radiotherapy in breast cancer patients. Twenty patients with histologically proven breast cancer, assigned to clinical stage II using the criteria of TNM (Tumour Node Metastasis) classification were divided into two compatative groups: the first one was treated with radiotherapy only, whereas the second one was additionally treated with TFX-thymomodulin. The quantification of CD2, CD3, CD4, CD8 and CDDR positive peripheral blood cells was performed before and after treatment in both comparative groups, using the indirect immunofluorescent technique. We found significantly lower reduction in CD4 and CDDR positive cells in the breast cancer patient group, treated with radioimmunotherapy, compared to the group, treated with radiotherapy only. TFX-thumomodulin could be effective in reducing the changes of examined surface markers, caused by radiotherapy in breast cancer patients.
 ...
PMID:[Changes in surface markers on peripheral blood lymphocytes, caused by thymic extract in breast cancer patients]. 1817 97

Although remission rates for metastatic melanoma are generally very poor, some patients can survive for prolonged periods following metastasis. We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions to search for a molecular basis for this observation and to develop improved methods for predicting patient survival. We identified a group of 266 genes associated with postrecurrence survival. Genes positively associated with survival were predominantly immune response related (e.g., ICOS, CD3d, ZAP70, TRAT1, TARP, GZMK, LCK, CD2, CXCL13, CCL19, CCR7, VCAM1) while genes negatively associated with survival were cell proliferation related (e.g., PDE4D, CDK2, GREF1, NUSAP1, SPC24). Furthermore, any of the 4 parameters (prevalidated gene expression signature, TILs, CD3, and in particular MI) improved the ability of Tumor, Node, Metastasis (TNM) staging to predict postrecurrence survival; MI was the most significant contributor (HR = 2.13, P = 0.0008). An immune response gene expression signature and presence of TILs and CD3+ cells signify immune surveillance as a mechanism for prolonged survival in these patients and indicate improved patient subcategorization beyond current TNM staging.
 ...
PMID:Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. 2030 34

Previously we have reported that a high frequency of E-rosette forming cells (T-cells) in the blood of newly diagnosed breast cancer patients was associated with the development of distant metastases and a short survival. In the present investigation, comprising 204 untreated breast cancer patients, we showed that the proportion of the total T-cell population (CD2 and CD3 positive cells) and the proportion of helper/inducer T-cells (CD4 positive) was positively linked to spread of cancer cells to axillary nodes which in turn Was strongly correlated to prognosis. The latter subset also correlated significantly to time to development of distant metastases. Cox multivariate regression analysis showed that the frequency of these lymphocytes, independently of other variables, predicted prognosis. Our present as well as our previous results do not support the view that a high proportion of T-cells in the blood forecast a good prognosis.
 ...
PMID:Blood lymphocyte subsets in operable breast-cancer - relation to extent of tumor disease and prognosis. 2157 2


<< Previous 1 2