Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (
R 7000
) has been proved to be a very potent mutagen. The purpose of this study was to demonstrate the carcinogenicity of a
R 7000
to male Wistar rats initially 6 weeks old.
R 7000
was dissolved in olive oil at a concentration of 1 mg/ml for injection. A S.C. injection of 0.5 ml containing 0.5 mg of
R 7000
was given once a week in the neck of each animal tested. Ten control animals were not injected and 10 animals received a 0.5 ml injection of olive oil every week to serve as control. The remaining 70 animals were divided into five groups. Four groups of 10 animals received a total of either 2.5 mg, 5 mg, 7.5 mg or 10 mg of
R 7000
; the fifth group of 30 animals received 12.5 mg of
R 7000
. In animals which did not receive
R 7000
, no malignant tumor was observed. In those to whom
R 7000
was administered tumors began to appear at the site of the injection after the third month. At the sixth month of the experiment, most of the animals injected had a tumor at the injection site. The number of tumor-bearing animals and the time between the first injection and the tumor appearance were closely related to the dose of
R 7000
injected. These tumors were high grade fibrosarcomas, one animal developed a salivary fibrosarcoma. No other tumors or
metastases
were found in the autopsied animals. The high carcinogenicity of
R 7000
in vivo is analogous to that of methylcholanthrene. The exact mechanism of action of 2-nitro-naphthofurans as carcinogens remains to be explained.
...
PMID:Induction of sarcomas in rats by subcutaneous injection of 7-methoxy-2-nitro-naphtho[2,1-b]furan (R 7000). 396 29
