Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear.
 ...
PMID:Malignant intraocular tumors. 680 Jun 27

From 1960 through 1976, 353 consecutive patients with carcinoma of the tonsillar region were primarily treated with radiation therapy. The mean age of patients was 58 years with males predominating (78%). Patients were classified according to a TNM and stage classification. Most of the tumors were large, and the specific site of origin could not be determined in 33% of the patients. The predominant identifiable sites were the soft palate and uvula, 18%, the anterior tonsillar pillar, 18%, and the tonsillar fossa, 13%. Patients were treated with radiation to doses of 6700 rad given in 48 days and 33 fractions using Cobalt 60 radiation. We found a 91.7% control rate for patients with T1 disease and 76.9%, 49.5%, and 25% for T2, T3, and T4 patients, respectively. The overall local control rate was 62.3%. Surgery was used most often in recurrences for Stage III patients. Salvage surgery was carried out in 93 patients. Surgery was more successful in controlling the disease in patients in whom the primary was controlled by irradiation. Overall, the tumors in 43% of the patients who had surgery were subsequently controlled as a result of this treatment. Metastasis occurred rapidly, with 75 of the patients exhibiting metastases by 18 months. Complications were not related to dose but were slightly higher in patients who had surgery (5%). We conclude that radiation therapy is the preferred treatment for Stage I and II squamous cell carcinoma of the tonsillar region. No satisfactory results were obtained in Stage IV; other approaches should be tried.
 ...
PMID:Radiation therapy of carcinoma of the tonsillar region. 683 15

Haemangiopericytomas are vascular tumours derived from Zimmerman's pericytes, the cells surrounding blood capillaries which correspond to the smooth muscle cells in the arterial and venous walls. This rarely observed tumour is usually found in the limbs (more than 50 p. cent of cases) or the face. Pelvic haemangiopericytomas are most frequently observed in women, and are then of uterine origin, their occurrence in men, and in the perivesical space, being exceptionally rare (seven cases reported in the publishing literature). The authors describe such a case, and review the clinical and radiological characteristics of the lesion. Diagnostic difficulties are emphasized, as confusion with a sarcoma can arise, even after histological examination. Surgical excision should be conducted routinely, but local recurrence or pulmonary metastases may occur in view of the potential malignancy of these tumours. Complementary cobalt therapy is therefore justified.
 ...
PMID:[A rare tumour: paravesical pelvic haemangiopericytoma (author's transl)]. 702 96

From July 1970 to January 1977, 23 patients with previously untreated cancer of the cervix (CA CX), mostly Stage IIIB, were included in this study. The para-aortic lymph nodes (PALN) were histologically documented to have metastatic disease in all 23 patients. External radiation treatment (RT) was delivered using a Cobalt--60 machine to a spade-shaped field to treat the pelvic cavity and para-aortic area. The majority of the patients received 4000-6000 rad to the pelvic cavity and from 5000-5500 rad to the PALN's by external RT. In addition, intracavitary radium was used in 21 patients. Five patients are alive and free of disease at 115, 110, 90, 73 and 45 months after completion of RT. One survivor had clinical Stage IB, one had Stage IIB, and three had Stage IIIB cervical carcinoma. Two of 15 patients with clinically enlarged and suspicious para-aortic nodes are alive, while 3 of 8 patients with clinically normal appearing nodes survived. Three (60%) of the survivors developed late bowel radiation damage. Eighteen patients died--10 during the first year, 3 during the second year, 2 during the third year, 1 during the fourth year and 2 during the eighth year of the follow-up. Five (27.8%) of the patients who died had developed late bowel radiation damage. Fifteen of the 18 died with disease at an average of 21 months. Three patients died of intercurrent disease. Their average survival was 40 months, double that of patients dying of disease. This report suggests that in cancer of the cervix, radiation therapy can control some PALN metastatic disease, but the risk of complications is rather high. In the absence of better methods of management, this risk of complications is justifiable because the alternative is to leave known disease untreated.
 ...
PMID:Para-aortic lymph node irradiation in carcinoma of the cervix after exploratory laparotomy and biopsy-proven positive aortic nodes. 706 Dec 47

The necessary application of a differentiated therapy for prostatic cancer requires the involvement of the N-category for determining the therapy. Hitherto existing statements on the lymphogenic metastases of this tumor have been made by means of method whose statements have been limited by the non-presentability of the pelvic lymph nodes, inflammatory-degeneratively changed lymph nodes, and micrometastases. The pelvic en-bloc-lymphadenectomy has been performed and the lymph nodes prepared in successive cuts in the light of a functional patient series of 93 prostatic cancer patients. The standardized procedure allowed statements on the distribution of the pelvic lymph nodes and the corresponding metastases, the size of the metastases and their histologic structure. In prostatic cancer is a high percentage of micrometastases. Lymphogenic metastases can already be detected in low tumor categories, on the other hand metastases are not obligatory in advanced tumors. There is no correlation between the histologic degrees of differentiation of the primary tumor and the lymphogenic metastases. Compared with the metastasis histology the primary tumor histology reveals a distinct morphologic change. According to present investigations, the lymphogenic metastases occur prior to the bone metastases. Since pelvic lymphogenic metastases cannot be covered exactly by means of the conventional methods as well as the metastases cannot be estimated in the single case, there is the necessity for making the pelvic en-bloc-lymphadenectomy before performing a localized tumor treatment such as prostatic vesiculectomy or tele cobalt therapy.
 ...
PMID:[Lymphogenic metastases in prostatic cancer--operative and histopathologic investigations ]. 712 58

The authors report the results of a trial of the treatment of recurrences of advanced carcinomas of the bladder using Cis-Diamino-Dichloro-Platinum administered by continuous IV infusion over a period of 24 hours at a dose of 100 mg/m2, under cover of hyperhydration and anti-haematizing drugs. The trial involved 10 patients who has had the following initial treatment : - excision for 8 of them (2 total cystectomies for T4, one total cystectomy for T3B, 2 total cystectomies for T3A and 3 partial cystectomy for T1); - preoperative cobalt therapy for 7 of them (2 flashes of 7.5 gray) - postoperative chemotherapy (VM26 and 5FU) for 5 patients. The targets evaluated were : 7 remaining pelvic tumours or recurrences, 3 lung metastases, two cases of venous compression with oedema of the lower limbs, 3 node metastases, 3 bone and 1 sciatic metastases. Results : - 1 complete remission with disappearance for 10 months in the same patient of pulmonary metastases, venous compression and an inguinal node; - 3 partial remissions for 2 to 9 months; - 2 minor remissions of 3 to 5 months; - 3 stabilizations and 1 progression. It is interesting to note the greater efficacy on distant metastases (2/3 complete disappearances of lung metastases, 2/2 disappearances of oedema of the lower limbs) than on pelvic tumours (4/7 regressions). In total, 4 objective responses out of 10 occurring between the 2nd and 6th week after the first course. The authors announce a valuable synergism of DDP with cyclophosphamide and adriamycin.
 ...
PMID:[Evaluation of the efficacy of cis-diamino-dichloro-platinum as monochemotherapy in the treatment of advanced malignant tumours of the bladder (author's transl)]. 719 29

A follow-up study of 69 patients with malignant tumors of the hypopharynx is reported. They were treated either with Cobalt-60-gamma-rays or with 19 MeV Betatron X-rays mainly up to a dose of 60 Gy over a 6 week period. 53 of the 67 patients with carcinomas had very large tumors (T3 and/or N3). The 3-year survival rate in group N0 was 15%, and in group N1--3 7%. These rates could not be improved on by radical operations prior to radiotherapy. 51 of the 67 patients with carcinomas died due to local or regional disease. 7 patients developed distant metastases. These results could not be improved on by increasing the dose to 70,0 Gy.
 ...
PMID:[Radiation therapy of tumors of the hypopharynx (author's transl)]. 723 Oct 18

In the years from 1968-1977 to 44 out of 63 patients with carcinomas of the nasopharynx and to 15 out of 19 patients with malignant lymphomas of the nasopharynx curative radiation therapy was applied. The survival-rates for all carcinomas amount to 63,2% after 3 years, and to 46,5% after 5 years. Half of the patients live up to only 9% of their mean, age- and sex-dependent life expectancy. The prognosis differs with the histological type. Patients with transitional-cell-carcinomas had the smallest chance of survival; half of them did not survive. 0.08% of their age-dependent life expectancy. Skeletal infiltration and metastases of the cervical lymph nodes have a bad influence on the therapeutic results. Local recurrences developed in 20% of the patients. Using the examples of 3 patients, who don't belong to the analyzed collective, we shall discuss and optimize the radiotherapeutic management. As a result it is found out, that the megavoltage irradiation therapy (42 MeV X-rays) makes a better dose distribution in tumour-volume than cobalt 60 rays.
 ...
PMID:[Carcinomas of the Nasopharynx. Clinical aspects--treatment results--therapeutical improvements (author's transl)]. 726 99

The authors propound five personal clinical cases of intra-thyroid metastases from epithelial carcinomas. Looking through the world literature, they found 134 other such cases. Analyzing these cases, there is a marked preponderance of renal cancers. The other most frequency primary cancers are of the breast, tract, lungs and skin epitheliomas. Undeclared metastases discovered at autopsy seem to be much more frequency (approximately 7.7% of those who die of their cancer have such metastases). This discrepancy between the rarity of clinical metastases and the frequency of microscopic metastases is explained by their very great latency and their very slow progress. This justifies the attempt at a curative treatment every time this is possible: surgery plus cobalt therapy. This can produce a fairly long survival rate: one year and four months on average when the metastasis is discovered before the primary cancer; two years and then months when the metastasis is discovered after.
 ...
PMID:[Metastases to the thyroid from adenocarcinomas. Review of the world literature around five personal cases (author's transl)]. 740 16

A case of adenocarcinoma of the prostate in a twenty-seven-year-old man is reported. He responded initially to cobalt radiation to the prostate, but metastases developed subequently and he died thriteen months after the histologic diagnosis was made. Three of the 4 previously documented cases in men below age thirty who also presented with symptoms of obstruction of the lower urinary tract or bone pain died four, five, and twelve months later. The other patient was asymptomatic and alive thirty-one months after detection on a routine physical examination. Although based on a small number of cases, men below age thirty with prostatic adenocarcinoma have a poor prognosis, which appears to be related to the presence of symptoms at the time of diagnosis.
 ...
PMID:Adenocarcinoma of prostate in a twenty-seven-year-old man. 742 9


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>