Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gene
C4orf7
, renamed
FDC-SP
(follicular dendritic cell secreted protein,
FDC-SP
) was first isolated from human tonsils. Up to the present, the function of this gene was still poorly understood. In this study, we report the expression of gene
C4orf7
in a panel of tumor types. The percentages of
C4orf7
positive expression in the tumor patients with
metastases
were notably higher than those in the cancer without
metastases
. On the contrary, the expression was hardly noted in normal tissues and corresponding benign lesions. In vitro, the up-regulation of
C4orf7
in ovarian cancer cell lines was associated with enhanced motility and invasiveness. Furthermore, the overexpression of
C4orf7
resulted in Akt ser473 phosphorylation and decreased E-cadherin expression. The role of
C4orf7
in ovarian cancer cell morphology, motility and invasion was demonstrated.
...
PMID:C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion. 2081 73
