Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Human
CUB and Sushi multiple domains 1
(
CSMD1
) is a membrane-bound complement inhibitor suggested to act as a putative tumor suppressor gene, since allelic loss of this region encompassing 8p23 including
CSMD1
characterizes various malignancies. Here, we assessed the role of
CSMD1
as a tumor suppressor gene in the development of breast cancer in vitro and in vivo. We found that human breast tumor tissues expressed
CSMD1
at lower levels compared to that in normal mammary tissues. The decreased expression of
CSMD1
was linked to a shorter overall survival of breast cancer patients. We also revealed that expression of
CSMD1
in human breast cancer cells BT-20 and MDA-MB-231 significantly inhibited their malignant phenotypes, including migration, adhesion and invasion. Conversely, stable silencing of
CSMD1
expression in T47D cells enhanced cancer cell migratory, adherent and clonogenic abilities. Moreover, expression of
CSMD1
in the highly invasive MDA-MB-231 cells diminished their signaling potential as well as their stem cell-like properties as assessed by measurement of aldehyde dehydrogenase activity. In a xenograft model, expression of
CSMD1
blocked the ability of cancer cells to
metastasize
to secondary sites in vivo, likely via inhibiting local invasion but not the extravasation into distant tissues. Taken together, these findings demonstrate the role of
CSMD1
as a tumor suppressor gene in breast cancer.
...
PMID:Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. 2776 75
