Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients with symptomatic cystic metastases from ovarian epithelial carcinoma underwent ultrasound (US)-guided percutaneous aspiration and temporary injection of 99% ethanol into the cyst. In the first case, the patient initially underwent surgical resection of the mass and received systemic chemotherapy, but the cyst recurred 2 months later. Percutaneous aspiration and ethanol sclerotherapy were performed twice in the second case; fluid reaccumulated 2 months after the initial procedure. No side effects occurred. During the follow-up period (8 months in the first case and 4 months in the second), no clinical recurrence of the initial symptoms was noted. At the end of that period, a recurrent but asymptomatic cystic lesion was revealed at US examination in the first case. In the second case, a minimal asymptomatic residual collection was depicted with computed tomography. The results indicate that this technique should be considered in patients with symptomatic cystic metastases from ovarian carcinoma and may have potential benefit in the palliative treatment of such lesions.
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PMID:Percutaneous ethanol injection for the treatment of symptomatic cystic metastases from ovarian carcinoma. Work in progress. 172 14

Two hundred and twenty-one cases of epidermoid carcinoma of the pharynx diagnosed between 1965 and 1984 were analysed. Fifty-seven per cent of the carcinomas were poorly differentiated and 57% of the patients had stage IV disease; 65% had lymph node metastases at the time of diagnosis. Radiotherapy was the primary treatment. Between 1977 and 1979, preirradiation chemotherapy was used and from 1979 the effect of the radiosensitizer misonidazole was investigated in split-course radiotherapy. Loco-regional failure occurred in 60% after primary treatment. No changes in treatment results were observed during four consecutive 5-year periods. The five-year corrected actuarial survival rate in the whole series was 33%. It is concluded that the treatment results are still unsatisfactory, and that chemotherapy, optimized radiotherapy, and radiosensitizers as used in the present series did not seem to improve the results. Alcohol and tobacco restriction is emphasized for prevention.
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PMID:Epidermoid carcinoma of the pharynx. Therapeutic results in a series of 221 patients. 200 82

Percutaneous ethanol injection (PEI) was performed under ultrasound (US) guidance in the outpatient department in 14 patients with 21 metastases 1.0-3.8 cm in diameter. The primary cancer was colorectal adenocarcinoma (seven patients), adenocarcinoma of the stomach (four patients), abdominal leiomyosarcoma (one patient), gastrinoma of unknown origin (one patient), and bronchial carcinoid (one patient). The indicators of therapeutic efficacy were US, computed tomography, fine-needle biopsy, and serologic markers. No complications occurred after a total of 175 treatment sessions. Complete response was obtained in 11 lesions, nine of which were less than 2 cm in diameter, and in all endocrine metastases (four lesions in two patients) with a maximum, recurrence-free follow-up of 38 months. Carcinoembryonic antigen values decreased in all patients but one for a 2-6-month period. The natural course of metastatic disease strictly limits the applicability of PEI, a local treatment. Single, metachronous, nonoperable metastasis of adenocarcinoma and endocrine metastases seem to be the only indications for PEI.
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PMID:Liver metastases: results of percutaneous ethanol injection in 14 patients. 202 79

The effectiveness of percutaneous ethanol injection therapy was investigated in 20 patients with hepatocellular carcinoma (six cases), or hepatic metastases (twenty-five cases). 131 ethanol injections were performed between december 1987 and march 1990 for 30 lesions. Indications for this procedure included inadequate response to conventional treatment and tumor diameter less than 5 cm. Histopathologic examination, performed in all cases, showed that the tumor was completely necrotic in 16 cases, partially necrotic in 8 cases and not modified in 6 cases (one patient was not evaluable). Alpha-feto-protein and CEA levels were decreased in 12/17 cases. 16 patients were still alive at the end of the study (the mean follow-up period was 11.3 months). We conclude that ethanol injection may be a valuable treatment for small hepatic tumors.
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PMID:[Ultrasound-guided percutaneous ethanol injection of small malignant tumors of the liver. Results in 20 patients]. 217 12

The first case of carcinosarcoma originating from the renal pelvis in Japan is reported. A fifty-five year old woman was admitted to the hospital on July 13, 1987, complaining of a one-year history of lumbago. On physical examination, a mass of child's head size was palpable in the right loin. There were other palpable masses in the posterior head (8 x 8 cm), left anterior chest (3 x 3 cm) and sacral region (3 x 3 cm). A chest X-ray showed multiple pulmonary metastases and an excretory urogram revealed a non-visualizing right kidney. Computed tomogram and renal angiogram suggested right renal tumor. Right renal arterial embolization with ethanol sclerosing was performed. She had previously undergone biopsy of the sacral lesion at another hospital, histological examinations of which pointed to suspected carcinosarcoma. She was treated by a combination chemotherapy with vincristine, adriamycin and cyclophosphamide. Despite one course of chemotherapy, her general condition deteriorated with progression of metastatic lesions in the regions other than the lungs. She died of the disease on december 9, 1987. Autopsy was performed. Sections of the right kidney showed a transitional cell carcinoma in-situ with squamous and glandular differentiation in addition to the chondrosarcoma. The metastases were found in the liver, lung and bone, all of which consisted of chondrosarcoma. On the other hand skin metastases consisted of both carcinomatous and sarcomatous elements. The pathological specimens were reviewed at the Armed Forces Institute of Pathology, Washington, D.C.
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PMID:[A case of carcinosarcoma originating from the renal pelvis]. 228 21

A medullary carcinoma of the thyroid was preoperatively diagnosed on ultrasonically guided fine needle aspiration biopsies. After cytocentrifugation, the tumor cells displayed a dense cytoplasmic silver granulation with the Sevier-Munger technique when applied to air-dried or acetone-ethanol-fixed samples and an obvious calcitonin immunoreactivity after fixation in Bouin's fluid. These methods may prove useful in the identification of nonpalpable metastases and recurrences of medullary carcinomas of the thyroid, especially since the cytologic typing of medullary thyroid carcinoma cells may be difficult with routine stainings.
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PMID:Cytologic diagnosis of a medullary carcinoma of the thyroid by Sevier-Munger silver staining and calcitonin immunocytochemistry. 243 62

Renal artery embolization without subsequent nephrectomy was used to treat renal adenocarcinoma in 25 patients. The tumour had metastasized in 15 cases, and was locally advanced in six cases and localized in four. The aim was palliation of local symptoms in 20 cases. It was achieved in 11 of 14 patients with gross haematuria and in three of six with severe local pain. No prolongation of survival time was evident, and all the patients died of renal adenocarcinoma within 38 months. Regression of metastases was not seen. In one patient, embolization with absolute ethanol was followed by infarction of the left colon and death.
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PMID:Renal artery embolization in the palliative treatment of renal adenocarcinoma. 244 59

The effectiveness of ultrasonically guided percutaneous ethanol injection therapy was investigated in 8 patients who had hepatocellular carcinoma (two cases), hepatic metastases from colorectal carcinoma (five cases) and hepatic metastasis from breast carcinoma (one case). Tumor diameter was less than 5 cm in all cases. Fifty-nine ethanol injection were performed for 11 lesions. Histopathologic examination, performed in all cases, showed that the tumor was completely necrotic in 4 cases, partially necrotic in 3 cases and unchanged in 4 cases. Serum alphafetoprotein and carcinoembryogenic antigen decreased in 5 out of 8 cases. Seven patients were still alive at the end of the study with a mean follow-up period of 10.7 months. We conclude that ethanol injection may be a valuable treatment for small hepatic tumors.
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PMID:[Treatment of minor hepatic tumors with ultrasonically guided percutaneous injection of absolute alcohol. Results in 8 patients]. 256 Apr 38

Classification of tumors is based on histogenesis and on determination of malignancy. In well differentiated neoplasias the tumor tissue reveals a similar morphological pattern similar to that of the normal tissue from which they have originated. In contrast less differentiated neoplasias do not show such similarities to normal tissue in conventional stains and special procedures such as electron microscopy or immunohistology have to be performed in order to detect cell specific products. In many undifferentiated tumors this is not possible because loss of differentiation and organisation in tumor cells do not allow the production of cell specific substances. A new possibility for determining the histogenesis of tumors is the use of antibodies which are specific for one type of intermediate filaments. Intermediate filaments are structures, which together with microtubules and microfilaments form the cytoskeleton. Intermediate filaments are composed of different polypeptides, which show a cell type specificity. Keratins are the intermediate filaments characteristically found in keratinizing and nonkeratinizing epithelia. Desmin is the specific intermediate filament type of sarcomeric, visceral and some type of vascular smooth muscle tissue. Vimentin filaments are characteristic of endothelial cells, fibroblasts, macrophages, chondrocytes and most but not all lymphatic cells and the only intermediate filament type present in these cells. Neurofilaments are composed of three different polypeptides, which form the so called neurofilament triplet and are characteristically found in central and peripheral neurons. Glial fibrillary acidic protein (GFAP) forms the intermediate filament system of normal and reactive astrocytes and also some ependymal cells contain GFAP. Thus cells and tissues can be divided into five different types by the use of appropriate polyclonal or monoclonal antibodies. In the current study we were interested to determine with a large number of specimens, whether primary tumors or metastases continue to express the intermediate type characteristic of the normal tissue. The following results demonstrate, there is abundant evidence that intermediate filaments can be used as cell type specific markers both for normal tissue and for tumors. 1. To exclude wrong negative results by intermediate filament typing, a reliable detection of intermediate filaments should be performed on cryostat sections or on material, which has been recently ethanol fixed and paraffin embedded. With many antibodies fixation of the tissue in formalin results in a decrease of reactivity.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Intermediate filament proteins as markers in tumor diagnosis]. 334 Nov 48

Milled black pepper (Piper nigrum) force-fed to Egyptian toads as a suspension in amphibian saline or injected subcutaneously in the dorsal lymph sac as an ethanol extract, induced primary tumours in the liver and secondary tumours in other organs (kidney and spleen). When applied to the skin of experimental animals as an ethanol extract, black pepper induced primary tumours in the liver and secondary tumours in the ileum and stomach. Tumours of the liver were diagnosed as hepatocellular carcinomas and those of the other organs as metastases of the primary liver tumours. It is speculated that one or more constituents of black pepper may be responsible for tumour induction in the organs of the Egyptian toad Bufo regularis.
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PMID:Carcinogenicity testing of black pepper (Piper nigrum) using the Egyptian toad (Bufo regularis) as a quick biological test animal. 336 2


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