Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the work results of focused, local therapy of the MMU (localised at choroidea) in the years 1988-92, with episclerally fixed applicators of the beta-emittors Ru106/Rh106 are presented. After this, so called "brachytherapy" (without enucleation), the group of 17 eyes (treated 18 times) was evaluated 18-54 months after therapy. Favourable results of treatment of the MMU at choroidea (small and localised) with episcleral, focused beta-radiation are emphasised. Up to December 31, 1992 at the group of 17 eyes healed MMU of the choroidea showed 58.8% of treated patients. Effective visual acuity (between 0.4-1.0) was preserved in 66.6% of the eyes. Exitus due to metastases occurred in 5 patients (24-48 month after therapy) showing the mortality rate 29.4%. These results are comparable with published statistics.
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PMID:[Results of treatment of malignant melanoma of the choroid using local beta-irradiation (Ru106/Rh106) from 1988 to 1992]. 820 50

The authors draw attention to the possible application, and present their initial experience with examination of serum for the presence of oncomarkers (using radioimmunological methods) in clinical practice of ophthalmooncology in a group of 12 patients treated at the First Ophthalmological Clinic, Faculty Hospital Comenius University, Bratislava in 1997. The mean age of the patients was 59 years. In the first sub-group are nine histologically confirmed malignant melanomas of the uvea (eight times after enucleation of the bulbus and once after block-excision combined with application of the beta-emitter Ru106). In the second sub-group are three patients (one female patient with MMU after application of the beta-emitter Ru106 without enucleation and two patients under investigation on account of a naevus of the choroid). In the whole group of 12 patients the following oncomarkers were examined: TK titre, TPA, B2M and NSE and the patients are monitored so far during a one year period of dispensarization. Elevated levels of beta-2-microglobulin (B2M) were recorded in 50% of the patients and elevated levels of the tissue polypeptide antigen (TPA) in 25% (in the group of histologically confirmed malignant melanomas of the uvea). On examination of the other oncomarkers (TK, NSE and FE resp.) no positive results were recorded. The importance of investigation of the mentioned oncomarkers in ophthalmooncology is in particular the possibility of early detection of metastases in patients after termination of treatment on account of a malignant melanoma of the uvea.
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PMID:[Use of oncologic markers in ophthalmic oncology]. 981 80