Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

30 patients with renal tumours were treated with Depo-Provera (Medroxyprogesterone). Among the 21 patients operated on without metastases and with an parallel metastasis (fibrous capsule, adipose capsule, peritoneum) in the course of 6 to 15 months no one died of a tumour progression. Among the 9 patients with a distant metastasis in one case the regression of the metastasis could be achieved, whereas in another case progesterone stopped the progression of the intraoperatively observed liver metastasis.
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PMID:[Experiences with Depo-Provera (medroxyprogesterone) in the treatment of kidney tumors]. 296 Nov 62

Sixty-two evaluable patients with advanced breast cancer were treated with medroxyprogesterone acetate (Farlutal. Erba) 500mg orally twice or three times a day. After thirty days, one patient had a complete response (1.6%), 33 patients had partial response (53.2%). 11 had stable disease (17.7%), and 17 progressive disease (27.4%). The response rates of bone, lung and chest wall metastasis were higher. And the older patients showed a better response than the younger. The response did not show significant correlation with KPS, menopausal status, disease-free intervals after operation, numbers of metastases and the dose of medroxyprogesterone acetate. The response rate in ER positive patients was higher than the ER negative, but the difference was not statistically different. The side effects of high-dose medroxyprogesterone acetate were well tolerated and the most common ones were weight gain and excessive perspiration.
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PMID:[Clinical trial of high-dose medroxyprogesterone acetate in advanced breast cancer]. 765 95