Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spontaneous hepatocellular neoplasms of B6C3F1 mice (basophilic neoplasms) as well as those induced with the herbicide Nitrofen (eosinophilic neoplasms) were observed with an image analyzing computer to determine if quantifiable morphologic differences existed between them. Several morphologic parameters were measured on 5 liver sections from each of the following groups: (a) unexposed control liver; (b) non-trabecular basophilic neoplasms; (c) trabecular basophilic neoplasms; (d) small well circumscribed eosinophilic neoplasms; and large irregular eosinophilic neoplasms without (e) and with (f) pulmonary metastases. The total number of hepatocytes per unit area was significantly smaller in the eosinophilic neoplasms than in the basophilic neoplasms or the controls. This was the result of a greatly increased cell cross-sectional area in the eosinophilic neoplasms, caused predominantly by a larger cytoplasmic cross-sectional area. Nuclear cytoplasmic ratios of cells in eosinophilic neoplasms were lower than in the other groups for this reason. This demonstrates that quantitative morphologic differences exist between the spontaneous and induced neoplasms, which supports the conclusion that Nitrofen is a true carcinogen, and not a promoting agent.
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PMID:Quantitation of differences between spontaneous and induced liver tumors in mice with an automated image analyzer. 627 11

A comparison was made of the histologic characteristics of naturally occurring and Nitrofen-induced liver tumors in (C57BL/6 X C3H)F1 (B6C3F1) mice. Whereas induced tumors generally consisted of solid sheets or nodules of frequently enlarged eosinophilic hepatocytes containing enlarged and/or hyperchromatic nuclei, the spontaneous neoplasms consisted predominantly of small basophilic cells containing oval or round nuclei and frequently arranged in trabeculae 1--2 cells wide. Within the livers of Nitrofen-treated animals, foci of hepatocytes resembling those within the tumor masses were also observed in the nonneoplastic areas. Metastases were not present in the lungs of any controls, whereas small emboli or large masses of neoplastic hepatocytes were present in incidences up to 29% in treated mice with tumors. This bioassay provides evidence that, in some cases, liver tumors in treated mice are morphologically different from those in controls and suggests that Nitrofen induces unique liver tumors rather than acts as a promoter of spontaneous neoplasms.
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PMID:Histopathologic differences between liver tumors in untreated (C57BL/6 X C3H)F1 (B6C3F1) mice and Nitrofen-fed mice. 693 64