Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Approximately 90% of patients diagnosed with non-small cell lung cancer (NSCLC) die due to distant
metastases
. However, the complicated molecular and cellular mechanisms involved in lung cancer metastasis remain poorly understood. Copine III (
CPNE3
), a member of a Ca
2+
-dependent phospholipid-binding protein family, was identified as a novel metastasis-associated protein in NSCLC in our previous study, however, its function in metastasis remains unclear. Here, we found that
CPNE3
was expressed at high levels in NSCLC tissues and advanced TNM stages and was significantly associated with poor prognosis. In addition,
CPNE3
interacted with phosphorylated erb-b2 receptor tyrosine kinase 2 (pErbB2) and receptor of activated protein C kinase 1 (RACK1) and activated the focal adhesion (FA) signaling pathway in NSCLC cells. Moreover, knockdown of RACK1 inhibited cell motility in the
CPNE3
-overexpressed NSCLC cells. These findings offer mechanistic insights into the oncogenic roles of
CPNE3
and the pivotal effects of
CPNE3
as a biomarker and therapeutic target for NSCLC metastasis.
...
PMID:CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. 3051 22
