Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Follow-up of 103 patients with squamous cell carcinomas of the auricula showed that 20 of them developed regional lymph node metastases. The effect of size, site and certain histological parameters on the occurrence of metastases was assessed. The incidence of metastases correlated with increasing size of the tumour.
HNO 1988 Feb
PMID:[Metastasis of cancer of the external ear]. 336 Jun 29

The giant-cell tumor (osteoclastoma) is very rare in the head and neck. Its histogenesis, diagnosis and classification are difficult. Although it is considered to be benign, it should be regarded by the clinician as malignant, because of its high recurrence rate, potential metastases and the difficulty of total removal. We performed an extended radical mastoidectomy in a 42-year-old woman with such a tumor of the petrous bone, primarily to prevent such complications.
HNO 1988 Mar
PMID:[A case of osseous giant cell tumor of the temporal bone and tympanum]. 336 Jun 34

A retrospective study of 24 children suffering from nasopharyngeal cancer (NPC) during the years 1974-1983 is reported. The diagnosis was delayed because of the primary tumor site and difficulty in examination. Cervical lymph node enlargement (83.3%) was the commonest presenting symptom. The diagnosis was usually confirmed by cervical lymph node biopsy. Boys were affected 1.6 times more frequently than girls. In all, 91% of our cases had an anaplastic carcinoma, and 70% were in stage T3 or T4. Supplementation of radiotherapy by intensive chemotherapy even for stages T1 and T2 improves the survival. Survival is decreased by cervical lymph node metastases.
HNO 1988 Apr
PMID:[Nasopharyngeal cancer in childhood]. 341 Jul 50

Bazex syndrome is a rare paraneoplastic syndrome with characteristic acral hyperkeratosis, seen only in men with either carcinoma of or metastases to the head and neck. The author describes a case of Bazex syndrome in which recognition of the hyperkeratosis led to diagnosis and treatment of the underlying tumour.
HNO 1988 Apr
PMID:[Paraneoplastic acrokeratosis: Bazex disease. A tumor-specific dermatosis in squamous cell cancers in the area of the head and neck]. 341 Jul 52

Verrucous carcinomas (Ackerman tumors) are rare. The tumor is slow growing, locally invasive and is not supposed to metastasize. It is therefore thought to be unnecessary to perform a neck dissection. Two patients with local metastazing verrucous carcinomas (oral cavity and larynx) are presented. The possibilities of therapy are discussed with reference to the two cases presented and according to the literature.
HNO 1987 Jan
PMID:[Lymphatic metastases of verrucous carcinoma (Ackerman tumor)]. 355 12

Hospital charts and autopsy reports of 148 patients with head and neck carcinoma were reviewed in order to assess the mortality from distant metastases and other primaries. 49% of the patients with uncontrolled local or regional disease died with distant metastases. Only 4% of these patients had a second primary. In patients with controlled local and regional disease the opposite was found. Distant metastases were uncommon (9%). Yet, 44% of the patients died of a second primary located in the upper aerodigestive tract or lungs. If life expectancy in patients with controlled head and neck carcinoma is to be improved, early detection of second primaries is important. As only 9% of patients with locally controlled disease die from distant metastases adjuvant chemotherapy is not indicated.
HNO 1986 Jul
PMID:[Significance of distant metastases and secondary cancers as a cause of death in patients with ENT cancers]. 374 14

The incidence of malignant melanoma is rising worldwide. Recognition of the biological types of malignant melanoma (nodular melanoma, superficial spreading melanoma, lentigo maligna melanoma, and acrolentiginous melanoma) have greatly helped to improve the prognosis in recent years. Determination of the depth of invasion in histological serial sections has proved to be of great prognostic value. Melanomas with minimal invasion have an excellent prognosis. Wide excision of the primary tumour is of utmost importance. The excisional margins should be 3-5 cm, but in superficial melanomas the width of excision may be less. Prophylactic neck dissection is unnecessary for superficial melanomas, it is necessary for lesions between 1 and 3.9 mm in thickness, whereas in tumours with a depth of invasion greater than 4 mm the outcome of the disease is not improved by prophylactic neck dissection. In metastasizing malignant melanoma the tumour mass should be reduced by surgical intervention. Survival is sometimes prolonged by several months or even longer when lymph nodes and metastases are excised. A radical neck dissection is indicated therefore when lymph nodes are clinically involved.
HNO 1986 Oct
PMID:[Malignant melanoma in the area of the head and neck]. 379 27

Seventy-seven adenocarcinomas of the salivary glands recorded in the Salivary Gland Register between 1965 and 1984 were analysed and classified histopathologically. The following results were obtained: 1. 2% of all salivary gland tumours and 10% of all malignant epithelial salivary gland tumours were allotted to the group of adenocarcinomas. The age peak lies in the 7th to 8th decade. 60% occurred in women, 58.5% were localized to the parotid gland, 28.5% to the minor salivary glands (palate, lips, and cheek), 11.5% to the submandibular gland and only 1.5% to the sublingual gland. 2. Solid, tubular and papillary adenocarcinomas can be distinguished. Additional criteria are microcysts, mucus production and grade of differentiation. 3. The solid adenocarcinoma (13%) is predominantly localized in the parotid gland and characterized by a low differentiation, invasive growth and metastases. 4. 62.5% of tubular adenocarcinomas (52%) are localized in the parotid gland, 27.5% to the minor salivary glands and 10% to the submandibular gland. Most of the tumours are highly differentiated. A distinct mucus production is present in 40% of the cases. Microcysts are very frequent. 5. Papillary adenocarcinomas (28.5%) are localized in almost 50% of cases to the minor salivary glands, 45% to the parotid and only 5% to the submandibular gland. Microcysts and mucus production can be observed in 50% of the cases. 6.5% of the cases have a mixed tubular papillary structure. 6. In differential diagnosis, thyroid gland carcinomas and metastases of other adenocarcinomas must be distinguished, the former by negative result of the thyroglobulin reaction, and absent mucus production. 7. Adenocarcinomas arise from the salivary duct system. Solid or tubular adenocarcinomas imitate stages of the embryonal development of the salivary ducts.
HNO 1985 Oct
PMID:[Adenocarcinoma of the salivary glands. The pathohistology and subclassification of 77 cases]. 406 17

The occurrence of adenoid cystic carcinomas of the parotid gland is relatively uncommon. From 1964-1974, we performed surgery on 20 patients with such tumors. In these patients, the course of the disease was characterized by local recurrences, the formation of hematogeneous metastases, and long survival times. We have found that patient prognosis is distinctly influenced by the histological type of the neoplasm. Thus, the tubular form has a much better prognosis than the cribriform or the solid types of tumors. On the basis of the "determinate survival rate" of our patients, we were unable to demonstrate a definite positive effect of either radical surgery or radiation therapy on the course of the disease.
HNO 1981 Apr
PMID:[The influence of therapy on adenoid cystic carcinomas of the parotid gland (author's transl)]. 626 83

Therapeutic results in 287 glottic and subglottic carcinomas stage I-IV are reported. After primary irradiation and salvage surgery of recurrences the actuarial 10 year-NED probability for tumours with normal mobility of the vocal cords was 78%, for those with impaired mobility it was 60% and for tumours with complete fixation in stage III it was only 27%. The relative actuarial 10 year-survival probability of the same groups were 96%, 82% and 35%. Salvage surgery was performed in 48/51 patients (94%) with radioresistent tumours or recurrences and was successful in 37/48 (77%) of the patients. The larynx could be saved in 162/210 (77%) curative irradiated patients. Primary irradiation can be recommended as the method of choice in glottic carcinoma T 1 + 2. It can be proved also in T3-tumours as alternative to preoperative irradiation and laryngectomy if adequate follow-up is possible, otherwise combined preoperative irradiation and laryngectomy is preferred. Dose levels equivocal to CRE 19 are recommended for curative irradiation of T 1 + 2 N0-tumours. For more advanced tumours T3 + 4 and cervical metastases greater than 3 cm about 10% higher doses are needed. Different fractionation schedules for curative and preoperative irradiation are discussed. A highly significant dose-effect relation was found for dose levels above and below CRE 18.
HNO 1984 Jun
PMID:[Radiotherapy of cancer of the vocal cords. Report on 287 patients]. 646 26


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>