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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 4665 neck lymph nodes from 151 patients with laryngeal cancer treated with primary surgery (laryngectomy plus conservative or radical neck dissection) were examined histologically. In all, 330 lymph node metastases were found and they were classified by size, number, site in the neck, and extranodal disease. These parameters were correlated with survival rates. The present UICC classification system for N/pN is discussed critically, and a pN classification is proposed that is relevant to both histopathology and prognosis.
HNO 1989 Dec
PMID:[Prognosis relevant pathohistologic classification of cervical lymph node metastases (pN) of laryngeal cancer]. 260 38

We compared the preoperative ultrasound findings with the histological results of 127 neck dissections for squamous cell carcinoma of the head and neck. We checked several sonomorphological criteria (size, shape, boundary, echo structure, arrangement, mobility) to assess their value in identification of metastatic disease. If all nodes found on ultrasound were classed as metastases, the specificity was 30%, because many lymph nodes showed nonspecific reaction only. Lymph nodes with a rupture of the capsule or central necrosis or being larger than 3 cm, proved to be metastatic in all cases. Round or oval nodes with a size of more than 2 cm were found to be metastatic with an accuracy of 89%. The almost certain (97%) identification of necks with no metastatic lymph nodes allows elective neck dissection to be avoided.
HNO 1989 Aug
PMID:[Value of sonomorphologic criteria in the identification of regional metastases of squamous cell cancers of the ENT area]. 267 25

Tumors of the head and neck are mainly squamous cell carcinomas of varying differentiation. If the tumor is advanced (T3-T4) or distant metastases are present, the tumor is often to be regarded as inoperable. If cure is unlikely or substantial functional impairment is to be expected, surgery may no longer seem reasonable, even for tumors limited to one side. Since either radiotherapy or chemotherapy alone or in combination are often disappointing or have considerable side-effects, it seems reasonable to try to inhibit malignant cell growth by administering a cytostatic agent by intra-arterial "superselective" chemotherapy using an implantable catheter. The method is simple, and the patients may also receive combined radiotherapy if necessary. Furthermore, ambulant treatment is possible, with a substantially reduced risk of infection. This is an advantage compared with other catheter techniques, particularly in view of the restricted expectation of life of patients with advanced tumor. The disadvantage of "A-port implantation" is that chemotherapy can only start after complete wound healing.
HNO 1989 Apr
PMID:[Catheter implantation for intra-arterial chemotherapy of malignant tumors of the head and neck]. 272 75

Tumour biopsies of 93 patients with head and neck malignancy were analysed by cytophotometry. Ploidy and the proportion of cells in S-phase were measured. Tumours were classified as proliferative if the S-phase fraction was greater than 8%; the rest were classified as being less proliferative. Proliferative tumours produce local and distant metastases earlier and more frequently, so that the proportion of cells in S-phase is of prognostic importance. The response to chemotherapy of irradiation was no different in either group.
HNO 1989 Sep
PMID:[Results of impulse cytophotometry in malignant tumors of the head and neck. A prognostic parameter?]. 280 11

Between January 1985 and December 1986 320 patients previously treated for squamous cell carcinoma of the oral cavity, pharynx or larynx made 1200 follow-up visits. During this period 25 recurrences, 4 distant metastases and 2 second primaries were diagnosed. Seven patients received further treatment with curative intention, but only 4 patients are alive with no evidence of disease 3 to 23 months after salvage surgery. Indiscriminate follow-up of all patients with head and neck carcinoma over an extended period of time does not appear to be warranted.
HNO 1988 Jan
PMID:[Consumption and value of regular after care by patients with squamous cell carcinomas of the larynx, mouth cavity and pharynx]. 283 53

We report two cases of chemodectoma of the larynx. A 70-year-old man underwent a laryngectomy in April 1984 for a tumor diagnosed as a squamous cell carcinoma but which postoperatively proved to be a chemodectoma. Ipsilateral cervical metastases appeared 2 years later and were removed by local excision. Shortly thereafter he presented with recurrent nodes in both sides of the neck as well as cutaneous metastases on the trunk. He was given chemotherapy using a DTIC regime (5-3,3-dimethyl-1-triazino imidazole-4-carboxamide). A 53-year-old lady underwent a total laryngectomy in May 1984 for an extensive chemodectoma of the larynx. The tumor had already invaded the trachea and thyroid gland. Distant metastases were not found. So far she is free of recurrence. We discuss the histology, site, clinical course and therapy of this extremely rare tumor.
HNO 1988 Apr
PMID:[Chemodectoma of the larynx (2 case reports)]. 284 80

The results in the management of 460 vocal cord carcinomas and 124 supraglottic carcinomas are reported. Of the vocal cord carcinomas, 63.3% were diagnosed in the early Tis and T1 stage. Seventy-six tumors were resected endoscopically, 128 by laryngofissure and chordectomy. Not one of these patients has lost his life, larynx or voice. In bilateral tumors of the T1b category, 2 patients developed local recurrences and lost their larynx. Sixty-two carcinomas of the Tis, T1a and T1b categories were irradiated primarily. Two of these patients died and 14 underwent laryngectomy for local recurrence. In T2 carcinomas a 5-year cure rate of 87.5% was achieved by vertical partial resection. The 5-year cure rate after laryngectomy or laryngectomy with neck dissection for T2N0 and T2N+ carcinoma was 86.2% and 75.0% respectively. Most treatment failures were due to late metastases which could not be controlled. In T3 carcinomas with a 5-year cure rate of 71.4% (N0) and 70.0% (N+) respectively, treatment failures were also mainly seen in patients with N0 necks where we did not carry out a prophylactic neck dissection. Five-year survival rates for primary surgery in supraglottic T1-T4 carcinomas were 100%, 82.4%, 84% and 58.3%. The widely hel opinion that laryngeal carcinoma should only be subjected to surgery for irradiation failure can no longer be sustained. More patients lose their larynx or their life after irradiation of small carcinomas than after primary surgery. Furthermore, too many patients have to undergo two major cancer treatments (irradiation and salvage surgery). In larger carcinomas radiotherapy produces a lower survival rate and too many patients require two stressful cancer therapies. The number of retained larynges is not substantially higher than with primary surgery. Primary irradiation for selected cases should be part of every therapy concept that aims at an adequate and individual treatment of every patient.
HNO 1989 Jan
PMID:[Results of treatment of 584 laryngeal cancers at the Ear-Nose-Throat Clinic of Marburg University]. 291 75

Pretherapeutic staging is essential for the management of head and neck cancer. The diagnostic value of liver, brain and bone scanning was estimated by a retrospective study of 281 patients. Bone and liver scans are useful for detecting distant metastases from head and neck cancer. Brain scanning should be replaced by computed tomography, if there is clinical suspicion of intracerebral metastases. Nowadays ultrasound examination of the liver is more useful than liver scans. Thus, bone scanning remains the only radioisotope method used in the routine pretherapeutic staging of head and neck cancer. Chest X-ray, abdominal ultrasound examination and bone scans are adequate methods for the detection of metastases. The management of malignant lymphoma needs a special and more detailed diagnostic approach.
HNO 1988 Nov
PMID:[Scintigraphic search for metastases in patients with neoplasms of the head and neck]. 323 60

During a 3 year period 572 high-resolution sonograms were carried out in the follow-up examinations of 348 patients who had been treated for ENT malignancy. Our experiences in routine application of this diagnostic method are described and illustrated by typical sonograms. Ultrasound findings of complications (chylous cysts, seromas, granulomas, fistulae) are demonstrated and the value and limitations of sonography in detecting lymph node metastases and primary recurrences are pointed out. In spite of the high accuracy of this method, it is not possible to differentiate between lymph nodes which are invaded by tumour and those with non-specific lymph adenopathy by echographic criteria only. We used ultrasound for follow-up studies on patients treated by irradiation or chemotherapy. Finally, sonography provided additional information on the exact site and size of the tumor. Real-time sonography is not time-consuming and can be applied without any special preparation of the patient. It has therefore become a satisfactory diagnostic method in the follow-up of patients who have undergone treatment of malignant tumors.
HNO 1987 Nov
PMID:[Role of sonography in post-therapeutic control of tumors of the head and neck area]. 331 77

Sixty-one patients operated on for malignant paranasal sinus tumours were investigated to elucidate the incidence and route of metastasis; survival rate, incidence of recurrent tumours, sex distribution etc. as well as possible exogenous causative factors. Adenocarcinomas have a better prognosis in women than in men and sometimes show local recurrences even 10 years and more after primary operation. Tumours of the paranasal sinuses often produce primarily hematogeneous distant metastases, with a fatal outcome. Occupational carcinogenic influence of wood dust seems very likely.
HNO 1988 Jan
PMID:[Clinical aspects and prognosis of paranasal sinus tumors with special reference to their etiology]. 335 Jul 1


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