Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Increased tumor radiosensitivity can be achieved by the technique of synchronisation, although as yet this relationship has only been partial. Our clinical experiences from 1970-1974 with this technique lead to the following considerations: 1. Synchronized radiotherapy (Telecobalt) is administered twice weekly, independent of adjunctive medications (such as fluoro-uracil, vincristin or bleomycin). 2. Synchronized radiotherapy does not change previous indications for operative intervention. 3. The described technique permits successful treatment of advanced tumors as well as postoperative tumor recurrences of recurrences in previously-irradiated tisssues. 4. The radiosensitivity of poorly oxygenated tumor tissues may be increased. 5. Radiation dosage must not be reduced. 6. Distant tumor metastases can also be treated with additional chemotherapy (as synchronized chemotherapy).
HNO 1976 Sep
PMID:[Five-years synchronized radiotherapy in treatment of carcinoma of the head and neck: clinical results, 1970--1974 (author's transl)]. 6 Nov 94

Chordomas can be categorized into those of clival, cervical and sacrococcygeal origin. The clival chordomas are primarily discussed in this report. In defining pathological anatomy or histology, a differentiation of benign from malignant chordomas by histological means alone is impossible. A preoperative diagnosis is only possible if tumor grows into the nasopharynx and allows a tissue biopsy to be taken. These tumors are clinically malignant though strict anatomic criteria for malignancy such as nuclear polymorphia or atypia, mitoses and metastases are rarely observed. The therapeutic results of operation and radiation are compared. Each alone fails because of the high recurrence rate of the tumor so that their combination is preferred. Although the prognosis of this disease is poor, one of our patients who was treated with radiation and surgery had a survival time of 14 years.
HNO 1979 Feb
PMID:[Chordoma - a review and report of two cases (author's transl)]. 42 97

Three instances of malignant melanoma of the larynx are reported. Tumour localization and infiltration are described and the differentiation from normal and pathological tissue changes is discussed. It is noted that distant metastases present late.
HNO 1979 Aug
PMID:[Malignant melanoma of the larynx (author's transl)]. 52 38

Four cases of metastases to the larynx are reported and 43 similarly reported in the literature are reviewed. Most were metastases from hypernephromas or melanomas, producing supraglottic soft tissue tumours. Metastases from bronchial and mammary carcinomas in most cases are "bone metastases" within the laryngeal skeleton. Metastases in the larynx from all other malignancies are extremely rare. The clinical picture is variable and can cause considerable diagnostic difficulty especially in laryngeal skeletal metastases. Solitary metastases can be successfully treated by surgery and irradiation.
HNO 1978 May
PMID:[Metastases to the larynx (author's transl)]. 65 73

In the past 18 years 34 patients (21 males and 13 females) with carcinoma of the tongue were treated in the author's clinic. Patients with T1N0 lesions were treated satisfactorily only with irradiation. Patients with advanced disease, such as T2-T4 with metastases, were classified into 2 groups. One group was treated surgically (hemiglosectomy and radical neck dissection) and postoperative irradiation (about 6000 rads). The other group was treated with preoperative irradiation (about 4000 rads) and the same operation as the first groups. The results are significantly different. In the first group, 15 patients out of 17 died from local or cervical recurrences, whilst in the latter group 12 patients of 14 are in good health. As two patients died from unknown disease the 5 year survival of this group is 100%.
HNO 1977 Jun
PMID:[The treatment of carcinoma of the tongue (author's transl)]. 88 44

In patients with cervical metastases conventional examination by ultrasound, CT or MRI imaging often fails to identify an unknown primary tumor. Also the retrieval of a recurrent malignancy may be difficult. Scintigraphy, utilizing technetium-99m (v) dimercaptosuccinic acid was chosen for a prospective study in 17 patients to evaluate its properties for imaging metastasizing squamous cell carcinoma of the head and neck. Scintigraphic findings were correlated with the results of clinical examination and conventional imaging techniques. In all cases the primary tumor revealed good uptake of 99mTc(v)DMSA. Manifest cervical metastases could only be imaged in some cases. In future, therefore, 99mTc(v)DMSA scanning may be used for the detection of unknown primary tumors. However, it does not appear helpful in the evaluation of cervical nodes.
HNO 1992 Nov
PMID:[Scintigraphic imaging of head and neck cancers with 99m technetium (v) dimercaptosuccinic acid. A prospective clinical study]. 133 46

The spread of metastases to the brain and the leptomeninges is usually a terminal event in patients with known malignancies. We report on two patients, in whom the diagnosis of a diffusely metastasizing carcinoma was considerably delayed by the initial symptom of a peripheral facial nerve paralysis. The clinical, neuroradiologic and cerebrospinal fluid findings are discussed. A malignant neoplasm with diffuse or focal metastasis to the leptomeninges is a rare cause of peripheral facial paralysis of unclear genesis. The necessity of a lumbar puncture plus magnetic resonance imaging of the brain to enable an early diagnosis is emphasized.
HNO 1992 Nov
PMID:[Peripheral facial paralysis as the first symptom of unknown metastatic primary tumor]. 133 47

Progressive unilateral sensorineural deafness and tinnitus developed in a 59-year-old woman over a 1-year period. Clinical examination showed a tumor mass which almost completely filled the tympanic cavity, and grew around the auditory ossicular chain. Histological findings revealed the tumor to be a primary carcinoid of the middle ear. Neuro-endocrine differentiation was confirmed immunohistochemically by positivity for neuron-specific enolase, chromogranin, pancreatic polypeptide and synaptophysin. Using electron microscopy, neuroendocrine granules could be visualized. In addition, both light and electron microscopy revealed that cells had an epithelial differentiation with mucin granules while immunohistochemistry showed a positivity for cytokeratins. The detection of intermediary filaments (immunohistochemically with vimentin and under electron microscopy) was unique to this neoplasm and has to be considered in distinguishing the carcinoid tumor from the papillary adenoma of the middle ear. Tumor prognosis is excellent with radical extirpation from the middle ear. In the case presented, there has been no evidence for either recurrence or metastases 10 months after surgical resection.
HNO 1992 Oct
PMID:[Carcinoid of the middle ear: a rare tumor with biphasic differentiation. Case report with special reference to immunohistochemistry and electron microscopy]. 142 31

We report three patients with metastases to the ENT-region mimicking a primary malignant tumour. A 36-year-old woman presented with vertigo, sudden hearing loss, partial facial palsy and headaches. CT scan suggested a meningioma or an acoustic neuroma. Histological examination of the neoplasm removed surgically showed a metastasis from an amelanotic melanoma. A 38-year-old woman with nodules in the tongue had dysphagia. The history revealed that she had been treated successfully with chemotherapy for a carcinoma of the uterine cervix one year ago. Histological examination of a tongue biopsy showed a metastasis from the uterine carcinoma. The primary tumour was in complete remission. The third patient was treated for recurrent epistaxis. Physical examination showed a tumour in the right nasal cavity. A CT scan showed a tumour of the ethmoid cells and of the maxillary sinus, protruding into the nose. Histology and immunohistology proved a metastasis from a primary carcinoma of the liver. Ultrasound and CT scan of the liver confirmed the diagnosis.
HNO 1991 Jul
PMID:[Metastasis to the ENT area]. 165 38

Metastases from primary tumours and distant sites to the maxillofacial region are rare. The establishment of an exact diagnosis is often difficult because of the atypical clinical and roentgenological appearances. Thirty-five cases of distant metastases to oral soft tissues and jaws are presented. The most common primary tumours were renal carcinomas followed by breast cancers. In most cases metastatic lesions lie in the distal segment of the mandible. The possibilities of treatment are very limited.
HNO 1991 Oct
PMID:[Incidence and clinical consequences of distant metastases in the area of the jaw/face]. 172 Oct 48


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