Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Helium ion irradiation is a promising alternative therapy for choroidal melanoma. In short-term follow-up (less than 5 years), more than 90% (18/19) of treated patients demonstrated tumor regression. We had to enucleate five eyes after helium ion therapy either because of continued tumor growth (four patients) or other complications (one patient). Two melanomas continued to grow and seemed to be radioresistant. In two other tumors it retrospectively seemed that the entire lesion was not inside the radiation field. In one patient total retinal detachment and glaucoma developed; enucleation was performed because of a painful eye. Metastatic disease developed in no patients. The treatment failures emphasize that there are a number of unresolved issues regarding the use of charged-particle irradiation in the treatment of melanoma. Further studies must be performed to answer these questions and better delineate the use of these newer forms of therapy.
 ...
PMID:Failure of choroidal melanoma to respond to helium ion therapy. 682 68

67 patients with different kind of lung diseases have been evaluated by intraoperative laser spectroscopy. 49 of them had lung cancer and 18 patients had nonmalignant tumors, tuberculomas and chronic abscess. Helium-neon laser has been used to study spectral parameters of a normal lung tissue and lungs with malignant and benign tumors intraoperatively. It was found that intensity of autofluorescence will increase in cancer tissue. This phenomenon may be used for differential diagnosis of a lung cancer with benign tumors and chronic pulmonary diseases. It was also shown that autofluorescence of metastatic lymph nodes is higher compared to their hyperplasia. That may be used for rapid diagnosis of metastases in mediastinal lymph nodes and intraoperative staging of lung cancer.
 ...
PMID:[Laser fluorescence spectroscopy in intraoperative diagnosis and staging of lung cancer]. 896 41

The role of videosurgery in the treatment of gastrointestinal cancers is still controversial. However port-site metastases, reported with high rate (0.6-21%) have reduced the enthusiasm and still represent object of research. Port-site metastases pathophysiology is not yet clear. However in the last years the incidence is decreased at a percentage less than 2% and similar to that reported after traditional surgery (0.6-5.3%) due to a patient selection and a better videosurgical technique. Implant for direct contact, pneumoperitoneum, gas utilized, trocar positioning and relative tessutal trauma, visceral manipulation, frequent instrumental reintroduction represent the main pathophysiologic factors involved. Pneumoperitoneum produces an increase of the abdominal pressure with turbulent flows and the CO2 (stimulating of neoplastic cells growth?) transports neoplastic cells at the port site. However metastases occurs only when an elevate cellular concentration is present "gas less" videosurgery is not free from this complication but with a lower incidence. "Chimney effect", due to the leakage of gas or fluid containing aerosol neoplastic cells at port site, represents another important factor. In accord with such studies employing alternative gas (Helium) reduces the implant of neoplastic cells. Port site parietal trauma produces fibrin deposites that represents a substratum for cellular implant, growth and protection against immunitary host defense. Wound ischemia induces a macrophagic activity decrease. In view of these concepts the surgeon must respect some mandatory principles in the videosurgical approach to neoplastic diseases. Safety parietal trocar fixation avoiding gas or fluid port site leakage such as abdominal desuffling only through trocars in site are mandatory. Instrumental cleaning with cytoxic solution (Betadine)--neoplastic cells are isolated from instrumental lavage liquid--such as as irrigation and sterilization (5 FU) of porte site are very important rules. Wound incision--never too small--must be accurately sutured. During operation cutting through or handling tumor are contraindicated, especially when the neoplasm involves serosa. Surgical specimens must be extracted in bags absolutely through parietal protection system. High vascular ligature represents another technical rule to respect in every case like in traditional surgery.
 ...
PMID:[Parietal metastasis in laparoscopic surgery of colorectal carcinoma]. 1222 76