Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0027627 (
metastases
)
103,950
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Metastatic disease
is the primary cause of mortality among patients with osteogenic sarcoma (OGS). In this study, we aimed to identify the relationship of
COPS3
gene expression to metastasis. Immunohistochemical staining for
COPS3
was performed on 65 OGS samples (37 without and 28 with
metastatic disease
); 18.9% (7/37) of specimens from patients with no metastasis and 57.1% (16/28) of specimens from patients with metastasis showed intense staining of
COPS3
. Comparison of
COPS3
expression between a poorly metastatic osteosarcoma cell line (SAOS-2) and highly metastatic osteosarcoma cell line (HOS) showed stronger expression of
COPS3
in HOS cells. Inhibiting
COPS3
function by siRNA resulted in reduced proliferation and migration of HOS cells. Inhibition of
COPS3
gene downregulated expression of the MAPK signaling pathway, which has an important role in metastasis of OGS. Our results suggested that overexpression of the
COPS3
gene might have important roles in metastasis of osteosarcoma cells.
...
PMID:RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. 2143 69
