Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Out of total 176 patients with cervical carcinoma treated with radical abdominal hysterectomy at GCRI, 27 developed recurrence. The results of this study (Study A) were compared with the study carried out by Figge & Tamini, 1981 (Study B) and Thomas W. Burke, 1987 (Study C) as the approaches in all the three studies were more or less similar. The recurrence rates were 15.3%, 11.8% and 11.3% respectively in three studies. In cervical stage IB carcinoma, which is usually treated with this line of treatment, the recurrence rates were 20%, 12.3% and 11.3% respectively in three studies. The highest recurrence rates were observed in adenocarcinoma/adenosquamous carcinoma i.e. 50% in Study A, 33.3% in Study B and 17.4% in Study C. The adverse effects of high risk factors such as lymph node metastases and CLS involvement were less in Study A as compared to B. The deep stromal invasion was equally responsible in both the studies. The mean and median time interval until observed recurrence with post-operative radiotherapy were better in Studies B and A. Nearly 86% developed recurrence within 24 months which is useful observation for predicting the prognosis in similar situations. The evaluation and comparison of studies stresses the importance of new approaches to treatment on the current modalities as the present approach seems to be less effective especially in the presence of high risk factors.
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PMID:Retrospective evaluation of recurrence after radical abdominal hysterectomy in patients with cervical carcinoma. 234 37

We analyzed 8 pathological factors in order to recognize which of them are statistically significant in worsening the stage of cervical cancer. Three factors (external third invasion, CLS, parametrial invasion) are highly significant (p less than 0.001) as regards lymphatic metastases, while no one statistical relation has been found among grading or histotype and cervical canal invasion. Comparing the 8 pathologic factors among themselves, we have observed that parametrium, corpus and CLS are highly related to external third (p less than 0.001); in the same way corpus is related to cervical canal and parametrium to CLS (p less than 0.001).
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PMID:Lymph nodal metastases and pathological patterns in cervical cancer: a critical review. 291 77