Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 138 patients 81 had multiple cancer metastasis into the brain and 57 -- singular. The main significance for the differentiation of singular or multiple cancer metastasis of the brain are clinical signs. Singular metastasis attaining a significant size may be expressed in monofocal symptomatology. In a small number (2 or 3) of metastasis there is usually a well expressed multifocal neurological symptomatology, inasmuch as they also attain a rather large size and are frequently located in both hemispheres or supra- and subtentorially. In a large amount of metastases, although they are small, they involve different parts of the hemispheres and consequently mental changes become more expressed. Hypertensive and focal symptoms are slightly expressed or may be absent altogether. For purposes of differentiating singular or multiple foci of special importance may be contrast methods of investigation (carotid angigoraphy) and EEG.
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PMID:[Differential diagnostic signs of single and multiple metastases of cancer to the brain]. 117 92

Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected size. In four animals metastases were found in distant locations in the brain; in three of these cases there was a retention of radioactivity in the tumor. The selective necrotizing effect on the tumor cells is interpreted as mainly due to emission of Auger electrons from intracellularly accumulated 201Tl, giving rise to very high energy deposition in the vicinity of the cell nucleus. The results should also have implications for the treatment of human malignant gliomas.
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PMID:Necrosis of malignant gliomas after intratumoral injection of 201Tl in vivo in the rat. 775 74