Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two mice of the TM strain, maintained on Purina chow supplemented with refined coin oil plus free fatty acids, in one case, and with refined corn oil without free fatty acids, in the other case, developed primary heart rhabdomyosarcomas. The tumors metastasized to the lungs and the kidney, in the first case, and to the lungs alone in the second case. One mouse of the TM strain, on the diet supplemented with corn oil plus free fatty acids, developed a fibrosarcoma behind the right anterior extremity. Metastases from the tumor were found in the liver, lungs and myocardium. Another mouse of the C57 Bl. strain, injected subcutaneously, in the interscapular region, at the age of 7 days, with a single dose of 30 mug of Delestrogen, developed, at the point of injection, a large rhabdomyosarcoma. At the age of 5333 days, when the animal was killed, metastases from the tumor were found in the intercostal muscles and in the heart. Three mice, one of the TM strain, on a diet supplemented with corn oil and cholesterol, and two of the C57 Br. strain, on a diet supplemented with raw egg yolk (rich in cholesterol) had organized blood clots in the atria (in two mice) and one extending into the ventricle.
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PMID:Primary and secondary heart tumors in mice maintained on various diets. 121 38

In 1959 a patient then aged 66 underwent castration for a small nodule in the prostate. Polyestradiol phosphate (Estradurin), 20 ml every 2 weeks, was given until 1975 when urinary tract abstruction required transurethral resection. The resected tissue showed malignant change. At that time metastases were not demonstrable. Extrogen therapy (Tace) was again given. The nodule had considerably increased in size. After 6 months of this therapy the patient began using Estradurin, 40 ml every 2 weeks. The question was asked regarding increasing the dose or using irradiation. The replying urologist stated that, if the nodule 1st found in 1959 was shown by biopsy to be a carcinoma, a radical prostatectomy or radiotherapy was then indicated to attempt a cure as castration or estrogen therapy is only palliative. Now a change to diethylstilbestrol, 1 mg orrally 3 times a day, is advised. Irradiation is not recommended unless bone pain or urinary obstruction occur.
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PMID:Progressive enlargement of prostatic nodule after castration. 1227 22