Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 25-year old female patient was admitted to hospital for respiratory failure with pulmonary miliary. Subsequently, clinical signs of pericardial tamponade developed. Echocardiography showed a tumour of the right atrium. Malignancy of the tumour was strongly suspected on the basis of magnetic resonance findings. At surgery, the tumour could not be removed and multiple biopsies showed that it was an angiosarcoma with metastases in the lymph nodes and the lungs, the latter presenting as carcinomatous miliary. This case is of interest because of the unusual way the tumour was discovered with a possible alternative diagnosis of cardiac tuberculoma, and because of the usefulness of magnetic resonance imaging to diagnose cardiac tumours and evaluate the extension of those which are malignant.
Arch Mal Coeur Vaiss 1988 Dec
PMID:[Contribution of nuclear magnetic resonance in right atrial angiosarcoma. Apropos of a case]. 314 45

The authors report on two cases of sacrococcygeal chordoma, with complications involving visceral organ metastases and distal bony metastases. Chordomas are malignant tumors which develop in adult subjects which originate from remnants of the embryonic notochord. Sacrococcygeal localization is found in 50% of the 1,300 cases reported in the medical literature, which represents 20% of sacrococcygeal tumors observed. The difficulty and the delay in diagnosing these tumors should decrease by routine CAT scan examination. Diagnostic certainty is based on histological examination, often suggestive of the diagnosis (physaliphore-like cells), possibly combined with ultrastructure and immunohistological study. The clinical course involves local recurrences, but there is a real risk of metastatic development, notably in the case of sacrococcygeal chordomas, with their incidence estimated at 17.5% of cases. Sometimes developing in later stages of their course, histological findings are similar to those of the initial lesion. Organs which are frequently the sites of metastases are the lung (48% of cases) and bone (26%), then the lymphatic organs, the liver, and subcutaneous tissue... Therapeutic management is unsatisfactory, with ideally, complete surgical excision of the initial tumor of its size permits and hence early diagnosis of this condition is a prerequisite for good results.
Rev Rhum Mal Osteoartic
PMID:[Metastatic chordoma. General review apropos of 2 cases]. 331 68

One hundred and thirteen cases of lympho-epithelial thymomas were studied retrospectively: 56 were of epithelial type, 20 of lymphocytic type, 30 were mixed and 7 were not defined. Eighty-eight were operated on (20 stages I, 47 stages II, 13 stages III and 8 stages IV). There were 69 primary resections (57 complete and 12 incomplete), followed by radiotherapy in 54 cases and 19 secondary resections after radiotherapy (10 complete and 19 incomplete). Twenty-five patients did not have an operation and were treated with radio- and chemotherapy. After primary resection the actuarial survival at 5 years was 64.07% and at 10 years 50.86%. After a secondary resection it was 43.74% at 5 years. After radiotherapy it was 18.67% at 5 years. In operated cases the prognostic importance of staging was confirmed. The cytological structure was not. In myasthenic cases the secondary respiratory complications worsened the prognosis. Post-operative radiotherapy seems to be justified in all cases, but its effect is not statistically significant when resection was complete. Those operated after radiotherapy only showed a benefit if the resection was complete. The outcome of metastatic disease in TLE has been under-estimated and seems to depend on local control of the tumour. The use of chemotherapy remains to be defined.
Rev Mal Respir 1988
PMID:[Lympho-epithelial thymoma. Anatomo-clinical and therapeutic study of 113 cases]. 336 35

The authors describe an original observation of secondary intrathoracic metastases due to a malignant adenomatoid tumour or mesothelioma of the testicular tunica vaginalis. The hypothesis of a primary pleural mesothelioma could be excluded here as could secondary pleural deposits from another neoplasm. The exceptionally malign potentialities of this common tumour of the testicular adnexae were reviewed as well as the extremely poor prognosis.
Rev Mal Respir 1987
PMID:[Pleural and mediastinal metastases from a malignant mesothelioma of testicular vaginalis membrane]. 344 76

Alveolar lavage is a simple technique giving access to the inner lung. The object of this study is to assess the place of alveolar lavage in pulmonary tumours in man. The systemic changes in the immune system are not touched upon, nor the search for tumour cells. The supernatant has revealed greater than normal levels of carcino-embryonic antigen in primary tumours and metastases. The immunoglobulins (IgE, IgA) are increased also. The ready collection of the alveolar macrophages (MA) around the tumour permits a study of their functional capacity: chemotaxis, phagocytosis, cytotoxicity. The chemotaxis of MA breaks down around a primary cancer even though it is not changed in pulmonary metastases. The data in the literature concerning the capacity for phagocytosis and of anti-tumour cytotoxicity are still fragmentary. Increasing the tumoricidal properties of MA is a prospect for future. Alveolar lavage is an additional diagnostic method. It allows for a progressive scrutiny of the local immunological response in broncho-pulmonary tumours.
Rev Mal Respir 1987
PMID:[Immunological data furnished by alveolar lavage in bronchopulmonary tumor pathology]. 349 32

We studied the clinical and radiological features of pulmonary metastases present in 4 out of 22 patients with medullary carcinoma of thyroid. Two patients presented with common metastases: macronodules in one, and micronodules in the other one. The other two patients presented initially with reticulonodular perihilar lesions on chest X-ray, leading to the diagnosis of sarcoidosis in both of them. The observation of such pulmonary metastases is original: initially latent, they progress very slowly, and they correspond to a lymphangitic spread of the tumour with amyloid deposition in peribronchovascular structures without alveolar involvement, as shown in one of our cases with pathologic study.
Rev Mal Respir 1986
PMID:[Pulmonary metastases in medullary cancers of the thyroid. Study of 4 cases. Originality of the lymphangitic form with amyloid stroma]. 374 85

Pulmonary metastases of a placental choriocarcinoma are common but they are rarely the presenting factor, and whenever there are pulmonary metastases in a young woman a systematic search is required. We report on 7 cases and emphasize several important points. The diagnosis rests on the level of Beta H.C.G. One should be cautioned about transparietal aspiration or fibreoptic biopsy in view of the haemorrhagic nature of the lesion. An extensive work-up should be performed before classifying patients as low, medium or high risk as on this will determine the type of chemotherapy, either monotherapy with Methotrexate or polychemotherapy. The duration of treatment will depend on the clinical, radiological and biological outcome.
Rev Mal Respir 1986
PMID:[Pulmonary metastases of a placental choriocarcinoma]. 378 26

The anatomo-radiological study was conducted in 6 cases of isolated malignant intra-osseous tumours of the hip: 1 osteogenic sarcoma of the femoral head, 1 supra-acetabular chondrosarcoma, 3 carcinomatous metastases of the femoral head (2 predominantly lytic and 1 osteosclerotic), 1 supra-acetabular carcinomatous metastasis. This study reveals why, in the early stages of the disease and depending on the experience of the observer, the radiological appearance of these lesions can be easily confused with those of various conditions frequently seen by the rheumatologist. The authors also discuss the interactions of the metastases with the biomechanical conditions of the affected bone.
Rev Rhum Mal Osteoartic 1985 May
PMID:[Malignant bone tumors of the hip. Anatomo-radiological correlation]. 385 7

18 French women with bone metastases of breast cancer were treated with norethisterone 60 mg per day (except 1 woman given 20 mg daily) for 2 months or until the end of the remission from 1969-1972. The patients ranged from 39-84 years (mean 57.7). In 16 breast cancer had 0een diagnosed 6 months to 16 years before (mean 43 months). Calcemia was less than 102 mg per 1; calcuria was above 250 mg per 24 hours in 3. The bone lesions were lytic in 13 and mixed in 5. Progestagens were the first treatment for bone metastases in 10; others had ovariectomy, androgens, cortisone, chemotherapy, adrenalectomy, and hypophysectomy. Since the response of these metastases is difficult to evaluate, the authors chose criteria of disappearance of pain and stabilization of radiographic lesions. In 6 patients pain was relieved within 2-4 weeks, and lesions stabilized or recalcified in 2. In 5 of the 6 erythrocyte sedimentation rate became normal in 2 months; calcemia normalized in 1; calcuria decreased in 4. Remission lasted 3-9 months (mean 5.6). After remission, androgens were effective in 3 or 4. In 6, norethisterone was stopped because it was ineffective. 6 others had to stop for intolerance: vomiting in 1, jaundice in 2, hypercalcemia in 3.
Rev Rhum Mal Osteoartic 1974 Jan
PMID:[Treatment of bone metastases of breast cancer with progestogens]. 482 May 23

In addition to the chemotherapy, surgery and physical treatments usually employed in the treatment of bony secondaries from renal tumours, the authors propose embolization. They have performed this procedure in 4 patients, using a mixture of isobutyl-2-cyanoacrylate and lipiodol. Arteriography is performed before and after the embolization which is carried out under local anaesthesia. Disappearance or relief of pain was obtained in each case. This technique in no way changes the prognosis of the disease, but it can improve the quality of life of these patients. A review of the literature reveals that metastases other than renal have already been embolized, as have primary malignant bone tumours. The authors describe their method, the incidents associated with treatment, the contra-indications and the supposed mechanism of the analgesic action of embolization.
Rev Rhum Mal Osteoartic 1984 Jan
PMID:[Therapeutic or palliative embolization aimed at analgesia for bone metastases of renal origin]. 619 11


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