Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is a pity that, in view of its important prognostic value and for technical reasons, or because of problems of interpretation, lymphography should no longer be part of a routine work-up for diagnosing melanoma. Indeed, bipedal lymphography can accurately reveal the extent of node invasion in case of palpable adenopathy. It provides for the monitoring of the retroperitoneal lymph nodes after inguinal curettage has been accomplished. This method may reveal metastases at the subclinical stage. Axillary lymphography is especially valuable in case of palpable adenopathy. It has prognostic value in case of positive isotopic-clinical node involvement. Above all, however, it enables discarding the diagnosis of any secondary invasion, and preventing otherwise systematic axillary node curettage in 41% of cases. Lastly, if findings are normal, it affords a means for long-term follow-up.
J Mal Vasc 1990
PMID:[The importance of lymphography in melanoma]. 235 59

We report a case of invasive lympho-epithelial thymoma with pulmonary metastases, treated by complete macroscopic excision of primary tumour and then by chemotherapy using CHOP-BLEO. The epithelial nature of the tumour was confirmed by immunohistochemical studies. Chemotherapy enabled a complete and prolonged remission (greater than 63 months). Therapeutic trials of CHOP-BLEO merit further assessment and the results should be compared to the baseline treatment using platinum and prednisolone.
Rev Mal Respir 1988
PMID:[Invasive thymoma with pulmonary metastasis. Complete remission 5 years after surgery and chemotherapy using the CHOP-BLEO protocol]. 246 85

The postoperative outcome of bronchiolo-alveolar epithelioma (EBA) is unpredictable. We question whether a study of the anatomo-pathological structures would enable us to detect prognostic indicators. The clinical characteristics, histopathology and outcome of 52 cases of EBA were studied. 31 tumours were detected in a systematic fashion; 50 patients had excision of the tumour and in 39 cases there was no invasion of the lymphatics. 10 were of the multicentric variety and 42 were of the nodular variety and 9 of these were the centre of an inflammatory lympho-plasmocytic reaction. 20 cases revealed mucinous differentiation and 32 were non-mucinous. In the latter cases nucleo-cytoplasmic anomalies were only slightly increased or even absent. Blood vessel invasion was present in 12 cases and metastases to the air spaces in 20. The overall survival was 83% in the first year, 65% in the second year, 42% at five years and 26.5% at 10 years. The nodular lesions were compatible with a significantly better survival than the diffuse forms. Other characteristics such as whether the tumour was mucinous or not, inflammatory, showed nuclear anomalies, blood vessel invasion and airborne metastases did not seem to affect survival.
Rev Mal Respir 1989
PMID:[Bronchiolo-alveolar carcinoma. Anatomo-pathological and evolutional study of a series of 52 operated cases]. 255 46

Between 1964 and 1987 35 patients were operated on for cerebral metastases due to an underlying bronchial carcinoma. In 26 cases (group 1) there was excision of the primary tumour also and in 9 cases combined medical treatment was given with radiotherapy and chemotherapy. The neurological state was improved by the neurosurgical operation in 88% of patients in group 1 and in 66% of patients in group 2. This improvement was maintained in 30% of the patients as long as they survived. 2 patients died following thoracic surgery (7.69%). The median survival was 11 months in group 1 and 9 months in group 2. Three patients in group 1 were living two years after craniotomy whilst. 1 patient in group 2 is still alive four years after the neurosurgical procedure. The heterogeneity of the two groups does not permit a comparative statistical analysis but overall there does not seem to be any difference in duration or quality of life between the two groups. Complementary cerebral radiotherapy did not affect the prognosis.
Rev Mal Respir 1989
PMID:[Should a cancer of the bronchi be surgically treated after excision of a cerebral metastasis?]. 260 15

Three hundred and four cases of small cell lung cancer diagnosed histologically were included in a randomised multi-centre trial (23 centres) from 1st January 1983 to the 30 September 1985, with no clinical criteria for exclusion. The clinical and laboratory data were taken from the initial assessment of the patients in the trial, and were compared with those in the literature. The sex ratio was 10:1, only 27 were women (9%) and all were less than 70. The mean aged was 60 +/- 10 (extremes 33 to 84 years) and 80% of the population was from 40 to 70 years. Tobacco consumption was virtually constant, only 7 were non-smokers and 7% of patients smoked less than 20 packs/year; indeed consumption was very heavy with a mean of 44 +/- 23 packs/years. 14% of cases were discovered on systematic radiological examination, but 39% of these asymptomatic patients already had disseminated disease. For the 304 patients overall, despite a very variable degree of dissemination from one patient and one centre to another, 163 (54%) had disseminated disease at the outset and 141 (46%) were apparently localised. The initial metastases were often multiple: extra-thoracic nodes (21%), hepatic (23%), osseous (20%), bone marrow (23%), cerebral (9%), and others (9%); these frequencies are underestimated in view of the fact that the investigations were not over-extensive. The serum carcino embryonic antigen levels were abnormal in 32% of cases. Fibroscopy remains the main diagnostic method to provide the histological proof for 90% of patients, but 4% had thoracotomies (of whom 3% were diagnostic thoracotomies).(ABSTRACT TRUNCATED AT 250 WORDS)
Rev Mal Respir 1987
PMID:[Initial clinical and paraclinical findings in 304 small cell broncho-pulmonary cancers of the 01 PC 83 trial]. 282 23

Secondary cardiac tumours are rare but but are now more frequently diagnosed by echocardiography. We report 6 cases of intracardiac metastases affecting the right heart which were diagnosed by 2D echocardiography. In 3 cases, a very mobile, oval-shaped tumour was visualised within the right atrium prolapsing into the tricuspid orifice in diastole like a myxoma but associated in 2 cases with signs of invasion of the inferior vena cava. Two other non-mobile tumours were observed causing massive invasion of the right atrium and the last case was of an infiltrating tumour of the right ventricle resulting in pulmonary infundibular obstruction. In the light of our experience and a review of the literature, it is difficult to distinguish secondary tumours of the right atrium from myxomas especially when the tumours are mobile and when it is impossible to visualise a pedicle inserted on the interatrial septum or tumoral invasion of the inferior vena cava. At the ventricular level, the diagnostic signs differ according to whether there is tumoral invasion of the cavity or infiltration of the muscular wall. These cases illustrate the value of 2D echocardiography in the diagnosis of intracardiac metastases, sometimes even in the absence of clinical signs.
Arch Mal Coeur Vaiss 1986 Mar
PMID:[Secondary tumors of the right heart. Echocardiographic aspects. Apropos of 6 cases in the adult]. 308 21

Ninety-nine patients suspected of having pheochromocytoma were studied with MIBG scintigraphy and in 92 of them were studied with computed tomography. In 49 patients, the diagnosis was ruled out, in 3 patients it remained doubtful, and in 47 patients it was confirmed. Two patients had epinephrine--and/or norepinephrine--non-secreting tumors and 45 had secreting pheochromocytomas. In these latter patients, there were 4 scintigraphic false-negatives, all intra-adrenal, and 4 computed tomography false-negatives, 3 extra-adrenal and 1 intra-adrenal. For about 80% of the patients and/or the tumor sites, both methods were thus in agreement. They were complementary in the remaining 20%. The advantage of scintigraphy is to screen the whole body with high specificity and to locate extra-adrenal sites or metastases of pheochromocytoma with better accuracy than computed tomography. The limits of scintigraphy are the possibility of false-negatives in around 10% of patients whereas computed tomography visualizes more than 95% of intra-adrenal tumors.
Arch Mal Coeur Vaiss 1986 Jun
PMID:[Comparison of MIBG scintigraphy and computerized tomography in the localization of pheochromocytomas]. 309 19

A case of myxoid liposarcoma of the left atrium in a 35-year old man is reported. The tumour, revealed by an atrial flutter, was excised. The patient died 13 months later, with multiple metastases. A review of the literature yielded only 7 cases of primary liposarcoma of the heart, including 4 which were surgically treated. This confirms the extreme rarity of a tumour which has a very poor prognosis due to recurrence in situ or metastatic spread.
Arch Mal Coeur Vaiss 1987 Oct
PMID:[Primary liposarcoma of the left atrium surgically treated]. 312 11

The value of pericardioscopy in pericardial effusion of uncertain origin was evaluated in 20 patients, aged from 18 to 77 years, whose pericardial effusion had been diagnosed by ultrasonography; 2 patients presented with clinical signs of tamponade. The cause of the pericarditis was unknown, but the clinical context suggested a malignant disease in 13 patients, tuberculosis in 5 patients and another cause in 2 patients. The pericardium was explored by means of a direct vision, cold-light endoscope, usually a mediastinoscope, introduced by the retroxiphoidal route under general of local anaesthesia. This method made it possible to study the pericardial fluid, examine the pericardial serous membrane, perform biopsies at a distance from the orifice of entry and cleanse the pericardium thoroughly in cases with blood or pus collection. Apart from 2 cases where the examination could not be completed because of an anterior mediastinal mass and a pericardial symphysis, valuable information could be obtained in purulent pericarditis (n = 1), chronic radiation induced lesions (n = 2), metastases (n = 2), haemopericardium (n = 2), and biopsies could be performed in tumoral or suspicious areas. These guided biopsies revealed a metastasis in 3 cases where the pericardial window was negative. No sign of tuberculosis was found in the 5 cases where the disease was suspected. The final diagnoses were: neoplastic pericarditis in 4 cases, radiation-induced pericarditis in 2 cases, purulent pericarditis in 2 cases, haemopericardium in 3 cases and idiopathic or reactive pericarditis in 9 cases. The post-operative period was uneventful, with no major complication ascribable to the procedure.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1988 Sep
PMID:[Value of pericardioscopy in pericardial effusion. Apropos of 20 patients]. 314 29

Modern two-dimensional imaging is of such quality that echocardiography is now capable of detecting intrapericardial formations. Three morphological types of abnormal intrapericardial echoes have been described: round masses, mattresses and linear echoes. These have been observed in effusions of various origin and seem to be lacking in aetiological specificity. In order to determine more precisely the echocardiographic signs of pericardial metastases, the authors have analyzed 7 cases of intrapericardial masses visualized in a series of 10 patients with metastatic pericardial effusion and examined in two-dimensional mode. These were echogenic and dense masses implanted on the pericardium and subject to cyclic movements linked with those of that membrane. Morphologically, they fell into two categories: round and sessile masses (6 cases) 8 to 23 mm high and 22 to 48 mm wide at their implantation; they were found mostly opposite the cardiac apex (4 cases) and/or in the lateral wall of the right ventricle (3 cases), oval formations (2 cases) which were 70 mm long and 17 mm wide in one case and 50 mm long and 15 mm wide in the other. One patient had two masses of different shapes. A review of the literature showed that these two echocardiographic images corresponded to two macroscopic types of pericardial invasion: either tumoral nodules or infiltration plaques betraying a diffuse invasion of the pericardium. All masses observed by the authors were located on the visceral leaflet of the pericardium. This predominantly epicardial location might be due to the visceral leaflet being selectively invaded by retrograde lymphatic embolization from the mediastinal lymph nodes.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1988 Dec
PMID:[Echocardiographic aspects of pericardial metastases. Apropos of 7 cases]. 314 40


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>