Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases are presented which depict the spectrum of neurological disability attendant on intra-axial brain-stem metastases, ranging from fulminant decline to a more leisurely and less disabling course. The rarity of primary glioma of brain-stem compared with brain-stem metastases in a general hospital population in the age group from 50 years and over is emphasized. Clinical deficit, certain ancillary findings, and response to therapy do not serve to separate brain-stem glioma from secondary brain-stem metastasis. The primary tumour may not be apparent when central nervous system symptoms appear or even for as long as two years after. It is recommended that the diagnosis of primary brain-stem glioma in the middle-aged adult be provisional and increasingly tentative over the age of 50 years.
 ...
PMID:Spectrum of symptomatic brain-stem metastasis. 118 27

Neurological involvement with systemic cancer is frequently a cause of major disability. Second to brain metastases, metastasis to the spinal cord and its nerve roots constitutes the most common neurological complication of cancer with an estimated 5 to 10% of patients developing spinal cord involvement that leads to serious impairment of function. With advances in cancer therapy and consequent extension of survival, the overall incidence of neurological complications of cancer is on the rise. Spinal cord dysfunction, while usually nonfatal, leaves the patient with a major neurological disability. The author discusses epidural metastases, highlighting the importance of early recognition and management.
 ...
PMID:Myelopathies in the cancer patient: incidence, presentation, diagnosis and management. Part 1. 183 42

Leptomeningeal metastases (LM) are most commonly observed in hematological malignancies. With prolonged survival in solid tumors, an increased frequency of metastases is noted in these tumors too. Early diagnosis, when the patient has minimal neurological disability, is associated with prolonged survival and improved functional outcome although the therapy is palliative. The diagnosis of LM is difficult, and the demonstration of tumor cells in the cerebrospinal fluid remains the gold standard. This can also be done by definitive neuroimaging. MRI is routinely used in this aspect. We discuss here a case where 18F-FDG PET/CT (Fluoro-de-oxy glucose positron emission tomography/computerized tomography) study helped us in the diagnosis of LM. Whole-body PET/CT imaging could be a useful tool in identifying the possibility of metastases of breast carcinoma in the usual sites and the not-so-usual sites of metastases.
 ...
PMID:18F-FDG uptakes in leptomeningeal metastases from carcinoma of the breast on a positron emission tomography/computerized tomography study. 1825 May 34