Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transcutaneous fine needle biopsy of retroperitoneal lymph nodes after lymphography minor is connected with only discomfort for the patient. It is used for clarification of a possible infestation of metastases by malignant growth, the lymphatic drainage of which is situated retroperitoneally. A new instrument for puncture is presented, the use of which permits increase in accuracy of impact and reduction of radiation exposure for both patient and examiner. These advantages are of great importance, especially in serial puncture of several lymph nodes along the lymphogenous pathway of metastases. The quality of the fluoroscopic picture is even improved by the instrument for puncture.
 ...
PMID:[Improvement in transcutaneous needle biopsy technics]. 746 34

Clodronate (Ostac) is a specific inhibitor of osteolysis from the group of biphosphonates. The efficacy and side effects of palliative treatment with the substance were investigated in an open prospective non-controlled pilot study in 41 patients with advanced, progressive, hormone-resistant prostatic carcinoma. All patients suffered from symptomatic bone metastases. Initially, they underwent an 8-day saturation course with 300 mg clodronate i.v. per day. A good to very good analgesic effect was achieved within 3 to 5 days in 29 patients (71%). The mean duration of action was 7 weeks and the mean survival time 12 weeks. There were no side effects after i.v. administration. Slight gastrointestinal discomfort was reported in 3 patients following oral administration. Delayed progression of the metastases was not observed. Clodronate is a promising addition to the other therapeutic possibilities in hormone-resistant prostatic carcinoma.
 ...
PMID:Biphosphonates as an adjunct to palliative therapy of bone metastases from prostatic carcinoma. A pilot study on clodronate. 750 26

Four cases are described of a distinctive morphologic variant of thymic carcinoid that was characterized by abundant stromal mucin admixed with the neuroendocrine elements resulting in a histologic picture reminiscent of metastatic mucin-secreting carcinoma. The patients were three men and a woman, aged 22 to 43 years. The tumors presented with symptoms of chest discomfort, cough, and dyspnea and were described as large anterior mediastinal masses on chest radiographs and computerized scans. Histologically, all cases showed nests and strands of tumor cells embedded in an abundant lightly eosinophilic, mucinous stroma with small cellular clusters as well as scattered single tumor cells seen floating in the mucin. The mucinous matrix was negative for periodic acid Schiff's and mucicarmine stains; alcian blue stains at pH 2.5 showed strong positivity of the mucinous material; this reaction was abolished by treatment with hyaluronidase, indicating the presence of nonepithelial stromal mucosubstances. Immunohistochemical stains showed strong positivity of the tumor cells with CAM 5.2, chromogranin, synaptophysin, and neuron-specific enolase, and negative staining with carcinoembyronic antigen and epithelial membrane antigen. Electron microscopy done in one case showed abundant dense-core cytoplasmic neurosecretory granules; there was no evidence of glandular secretory activity by the tumor cells. The tumors in two patients behaved in a highly aggressive fashion, with invasion of the chest wall, recurrence, and metastases to the lungs, pleura, and axillary, retroperitoneal, and mesenteric lymph nodes. Thymic carcinoid should be considered in the differential diagnosis of mediastinal neoplasms displaying prominent mucinous features. Application of immunostains and electron microscopy will be of value for establishing the correct diagnosis in this setting.
 ...
PMID:Thymic carcinoid with prominent mucinous stroma. Report of a distinctive morphologic variant of thymic neuroendocrine neoplasm. 757 90

Six cases of mucoepidermoid carcinoma of the thymus are presented. The patients were two men and four women aged 17 to 66 years (median age, 34.5). Clinically, three patients had symptoms of chest discomfort and three were asymptomatic. Grossly, the tumors in three patients were described as cystic structures varying in size from 7 to 8 cm in greatest dimension, with focal areas of induration within the walls of the cyst that averaged from 1.5 to 3 cm. The other three cases had grossly and radiographically well-circumscribed, homogeneous tumor masses. Histologically, the lesions showed a spectrum of features that ranged from those of well-differentiated, to moderately well-differentiated, to poorly differentiated mucoepidermoid carcinoma, with sheets and solid islands of squamoid cells admixed with mucin-secreting epithelium lining gland-like spaces. In four cases, the tumor was histologically seen in continuity with the epithelial lining of multilocular cystic structures; the nonneoplastic components of the cysts contained abundant inflammation and showed the features of otherwise conventional acquired multilocular thymic cysts. Clinical follow-up showed that the two patients with intermediate and high-grade tumors died within 2 and 7 months after initial diagnosis. One of these patients showed at autopsy residual tumor limited to the mediastinum, whereas the other patient died with metastases to pericardium and myocardium despite postoperative radiation therapy. Two patients with low-grade tumors were alive and well with no residual disease 2 and 3 years after surgery, and the other two were lost to follow-up. Mucoepidermoid carcinoma of the thymus should be included in the differential diagnosis of cystic neoplasms of the thymus. As with their counterparts at other sites, the biologic behavior of these tumors closely correlates with their degree of differentiation and amount of cytologic atypia.
 ...
PMID:Mucoepidermoid carcinomas of the thymus. A clinicopathologic study of six cases. 779 81

A 58-year-old male complaining of pollakisuria, miction pain and back pain visited us Dec. 26, 1979. Rectal examination revealed the prostate enlarged by 5 digital width, stony hard and irregular. Transrectal needle biopsy revealed moderately differentiated adenocarcinoma of the prostate. Bladder neck invasion, pelvic and mediastinal lymph node metastases and multiple bone metastases were found. The case was diagnosed with prostatic adenocarcinoma T3N2M1 (OSS, LYM) stage D2. Three courses of chemotherapy using ifosfamide applied from Feb. 2, 1980 showed no marked effect except for partial pain relief. Hormonal treatment with diethylstilbestrol diphosphate was started from May 28 and arterial infusion chemotherapy using CDDP and 5-FU was performed 2 months later, resulting in size reduction of the prostate and pelvic lymph node metastases and disappearance of mediastinal lymph node metastases. Needle biopsy of the prostate was negative for cancer cells. After 8 months, Tegafur was started, and 12 months later radiotherapy was added to the prostate and pelvic lymph nodes. The abnormal accumulation in bone scan began to decrease after 14 months and achieved complete remission 28 months after the initial therapy. We discontinued the hormonal therapy 31 months later because of his complaint of chest discomfort and palpitation. At the present time, 14 years after the initial therapy, the prostate was 35 x 29 x 19 mm in size on transrectal ultrasonography with undetectable serum PSA level and no tumor cells but only mass fibrosis has been seen by pathological examinations. We considered this patient to be with no evidence of disease.
 ...
PMID:[A case of completely responding stage D2 prostatic cancer with no evidence of disease 14 years after diagnosis]. 780 48

Because small volume lymph node metastases are difficult to recognize despite modern imaging techniques and since staging laparoscopy is costly and leads to important patient discomfort, pelvic then para-aortic lymph node endoscopic dissection has been introduced for staging gynaecological cancers. Since 1988, we have performed 110 pelvic and 17 para-aortic lymph node dissections using this technique. Pava-aortic endoscopic biopsy is indicated for advanced cancer of the cervix and subrenal biopsy for cancer of the ovary. Pelvic node dissection alone is useful in early stage cancers of the uterus and in cancers of the endometrium as well as in urological indications.
 ...
PMID:[Celioscopic pelvic and para-aortic lymphadenectomy]. 780 78

Although modern imaging techniques have improved diagnostic specificity in osteolytic and osteoplastic lesions, histological examination is often still mandatory when primary bone tumors or skeletal metastases are concerned. We have developed a percutaneous puncture set, including sufficiently steady, but still fine biopsy needles (1.4-2 mm) and a slow rotating drill accessory. With this set, histological material can be obtained from almost anywhere in the skeleton with local anesthesia low complication risk, and low patient stress and discomfort. Together with the high accuracy of CT- or fluoroscopy-guided puncture (near 95%), this allows biopsies to be taken on an outpatient basis, with broad indications. Biopsy can be used early when making a diagnosis. Tedious searching for the primary tumor can thus be avoided with subsequent economic benefits.
 ...
PMID:[Percutaneous needle biopsy in skeletal metastases. Indications, technique, value and results]. 789 40

We report a very rare case of small cell carcinoma of the stomach. A 69-year-old man, complaining of epigastric discomfort, was admitted to our hospital. Gastric endoscopy showed a Borrmann type 3 tumor at the lesser curvature of the cardia. Multiple liver metastases were observed in CT-scan, and total gastrectomy and cannulation to the hepatic artery were carried out. Macroscopically it was gastric cancer with P0H3N1T3M0, Stage IV b, histologically small cell carcinoma, intermed, INF gamma, ss, ly1, v3, n1(+), ow(-), aw(-). Immunochemotherapy was carried out, but liver metastases developed. The prognosis of this disease is very poor, resulting from rapidly developing metastases and invasion, in spite of treatments such as gastrectomy, chemotherapy and radiotherapy. More effective treatments are needed.
 ...
PMID:[A case of small cell carcinoma of the stomach with multiple liver metastases]. 794 74

Oral cancer currently strikes about 31,000 Americans each year. Survival rates are approximately 50%. However, early detection followed by appropriate treatment can increase cure rates to about 80%, and greatly improves the quality of life by minimizing extensive, debilitating treatments. An early oral cancer can appear as an innocuous red or white change, an ulcer, or a lump, mimicking many benign lesions. Additionally, when the discomfort is minimal, professional consultation is often delayed, increasing the chance for local spread and regional metastases. Vital staining with toluidine blue and exfoliative cytological examination can aid early detection by accelerating the biopsy of lesions that cannot be classified adequately or made to disappear.
 ...
PMID:Oral cancer. 806 Aug 25

Damage to the pelvic bones after radiotherapy for gynecological malignancies is uncommon with megavoltage radiotherapy. It can be misdiagnosed as bony metastases and is a diagnosis of exclusion. We report 12 women, who were treated for endometrial or cervical carcinoma who developed osteitis, femoral head or neck necrosis, or insufficiency fractures of the acetabulum, pubic symphysis or sacroiliac bones after radiotherapy. Many had multiple areas of bone damage. The prescribed external beam dose ranged from 40.0 to 61.2 Gy. All but one patient developed bony discomfort or pain as a symptom. Bony changes of the pelvic girdle appeared between 6 months and 8 years after irradiation. Radiographic studies including plain films, CT or bone scans were performed in these patients and showed correlative changes. Bone scans showed increased radionuclide uptake in affected bones. The subsequent favorable clinical course and outcome with resolution of symptoms confirmed the diagnosis of radiation osteitis. Therapy recommendations are conservative with avoidance of weight-bearing, use of analgesics and physical therapy. Femoral head necrosis/fractures required arthroplasty. Proper shielding, use of multifield technique, treatment of all fields per day, and awareness of tolerance doses are recommended.
 ...
PMID:Radiation osteitis and insufficiency fractures after pelvic irradiation for gynecologic malignancies. 819 13


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>