Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Unsuspected sacral fractures may present with confusing clinical, radiographic, and scintigraphic findings. Sacral fractures were diagnosed by radionuclide bone scans in 23 patients, most of whom were osteopenic and had only minor or no trauma. Symptoms usually consisted of low back pain, sometimes with radiculopathy, but some of the patients were asymptomatic and the fractures discovered coincidentally. Abnormalities on bone scanning consisted of increased uptake in the body of the sacrum and one or both sacral alae or only in a single sacral ala. A retrospective review showed abnormalities on radiographs in 11 of the 23 patients and in all four of the CT scans obtained, but the abnormalities were often overlooked or misinterpreted on the original reading. Bone biopsies of the sacrum, done in two patients to rule out metastatic disease, showed reactive bone formation consistent with fracture. Recognition of the characteristic scintigraphic patterns in sacral fractures and the frequency of these fractures in osteopenic patients can avoid mistaken diagnoses and unnecessary tests or treatment.
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PMID:Unsuspected sacral fractures: detection by radionuclide bone scanning. 387 Dec 81

Although imaging techniques have improved greatly in recent years, plain radiography remains the initial imaging method for evaluation of patients with low back pain. The sacrum, in particular, is a difficult structure to evaluate. In reviewing 12 cases, the authors found an unacceptably high rate of missed sacral metastases (83%). Using a photograph and a radiograph of two bony pelvic specimens to represent normal anatomy and the normal appearance of the sacral foraminal lines, sacral destruction is illustrated in six cases. All lesions were neoplastic and most were metastatic. In each case there was destruction of one or more sacral lines. The importance of careful observation for symmetric appearance of these lines is emphasized.
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PMID:Sacral destruction: foraminal lines revisited. 387 98

A case of renal cell carcinoma developing from a unilateral dysplastic kidney is reported. A 33-year-old woman was admitted to our hospital because of lumbago due to metastatic cancer to the bones. She was treated with interferon and combination chemotherapies, but died nine and a half months after initiation of the therapy. Autopsy revealed a widely metastasized renal cell carcinoma originating from a dysplastic left kidney. This is the second such case in the literature. Clinical management of renal dysplasia should take into consideration the possibility of developing malignancy.
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PMID:[A case of renal cell carcinoma developing from a dysplastic kidney]. 407 63

Eighty two cases of renal cell carcinoma, treated at our Department between July, 1971 and May, 1984, are reviewed. The highest incidence of this disease was seen in the 5th decade and the average age of the patients was 58.8 years. Male patients predominated over the female patients, the ratio being 1.6: 1. According to Robson's classification, thirty eight cases were in stage I, five cases in stage II, nine cases in stage III and thirty cases in stage IV. The overall survival rate at one, three and five years was 77, 58 and 48%, respectively. The most common symptom was macroscopic hematuria, followed by asymptomatic, lumbago and palpable mass. The site of distant metastases was most frequently in the lung, followed by the bone, liver and lymph node. There were no remarkable differences in the prognosis of stage I patients, between the group treated with preoperative renal arterial embolization and non-treated group. No remarkable difference was seen between the survival rate of the stage IV patients treated by nephrectomy and these not treated by nephrectomy. Renal arterial embolization was an effective therapeutic measure for patients with non-resectable stage IV renal cell carcinoma (p = 0.0647, compared with non-treated group).
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PMID:[A clinical study of renal cell carcinoma]. 409 Nov 34

Electromyographic studies were performed on 16 patients with intractable low back pain and no antecedent history of malignancy or metastatic disease. In each case, electromyographic evidence of severe segmental denervation limited to the paraspinal muscles innervated by the posterior primary rami was found. Subsequent diagnostic studies in each patient revealed a primary neoplasm or tumor metastasis as the source of pain. Applying current knowledge of neuromuscular physiology, the electromyograph may prove to be a valuable aid to the early detection of remote metastasis to the spine and paraspinal muscle structures.
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PMID:Electromyographic findings in patients with low back pain due to unsuspected primary and metastatic spinal or paraspinal muscle disease. 645 39

Case-reports of 85 patients with upper urinary tract tumors were reviewed. Mainly affected were males (87% of cases), particularly over 60 years of age, the principal presenting sign being hematuria. Other signs such as renal colic, lumbago or infections were observed more rarely. The renal pelvis was affected in 52 of the 85 patients (two of these were bilateral), multiple tumor foci being present in only 6 cases. Most tumors were epitheliomas (62 papillary and 13 non-papillary), with 52 of these at the superficial stage (0 or A), 21 at stage B 1 and 5 at stage B II or C. Based on Broders' classification, 48 were grade II and 16 grade III tumors. Prognosis was routinely poor in 5 patients with a stage B or C tumor and lymph node extension. Diagnosis is by intravenous urography, although retrograde ureteropyelography has its place, with increasing interest being given to ultrasound and computed tomography examinations combined with routine cystoscopy. If no particular contraindications exist, the preferred treatment is a total one-stage nephro-ureterectomy without curettage (52 cases), although curettage was performed at the same time in 9 other patients. Conservative surgery has only a limited application: 6 patients had segmental resections of the ureter and 2 patients underwent tumorectomy. Postoperative mortality was particularly loco: 4 patients (4,7%), mainly from vascular or respiratory diseases. (4,7%), mainly from vascular or respiratory diseases. Bone (5 cases), pulmonary (3 cases) and medullary (1 case) metastases represented the main cause of death during the year following surgery, all these patients having infiltrating tumors.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Tumors of the upper urinary tract. Analysis of a series of 85 cases]. 649 44

A 53-year-old woman was admitted to our hospital because of genital bleeding. The clinical diagnosis was cancer of the corpus uteri with much ascites. During the course of 10 months of illness, she complained of low back pain, so we diagnosed the sacral metastasis by scintigram. Autopsy examination revealed simultaneous triple malignancies of the right ovarian cancer, the sacrococcygeal chordoma, and the thyroid cancer. Histologically, the ovarian cancer was papillary cystadenocarcinoma with widespread metastases. The chordoma invaded the bone marrow of the sacrum. The thyroid cancer was follicular carcinoma without metastasis. This combination is very rare.
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PMID:[Autopsy case of simultaneous triple malignancies--ovarian, chordoma and thyroid cancers]. 663 20

Metastases of malignant tumor to the kidney are observed rather frequently at autopsy, but rarely found in living patients. Two cases of metastatic renal tumor were found at our clinic. One was a 35-year-old male with esophageal tumor. Five months after on operation for the esophageal tumor, he had asymptomatic macroscopic hematuria and had urological examinations at our clinic. X-ray and ultrasonographic examinations suggested a metastatic tumor in the left kidney. Left nephrectomy was performed. Pathohistological examination revealed a metastatic esophageal tumor in the kidney. Five months after the nephrectomy, right lumbago and macroscopic hematuria appeared. Metastatic right renal tumor was diagnosed with X-ray and ultrasonographic examination. Chemotherapy was conducted, but he died three months later. The other case was a 69-year-old male with left lung cancer (squamous cell carcinoma) who had left partial pneumonectomy . In the second year after the operation, he developed asymptomatic hematuria. After X-ray examinations and 67G -citrate scanning, a metastasis to the right kidney was diagnosed. No special treatment for the metastasis was given to the patient because of his failing condition. He died four months later. Metastatic renal tumors present a worse prognosis than primary renal cancer. This seems to be because the former progresses rapidly after its discovery. When a patient with a previous history of malignant tumors in any organ develops hematuria or lumbago, detailed examinations of the kidney should be performed.
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PMID:[Metastatic renal tumor]. 667 3

Retroperitoneal fibrosis is an uncommon disease of diverse etiology. Carcinoma of the breast is rarely considered as a cause of retroperitoneal metastasis or fibrosis. This paper describes five patients with retroperitoneal fibrosis secondary to breast cancer. The mean duration from initial diagnosis to onset of symptoms was greater than ten years. The patients had received a variety of treatments for breast carcinoma and had extensive metastatic disease. Presenting symptoms included abdominal, flank, or low back pain. Two had small bowel obstruction and four had ureteral obstruction. It is possible that with long-term survival this complication may be seen more frequently.
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PMID:Breast cancer and retroperitoneal metastasis. 744 44

Extracranial metastasis of glioblastoma is rare. This is an autopsy case report of a patient with glioblastoma multiforme found to have metastasized to the liver. A 42-year-old woman was admitted with a chief complaint of headache. Physical and neurological examinations on admission showed no abnormalities. CT and MRI demonstrated a tumor in the left parietooccipital region with invasion into the subependymal area of the left lateral ventricular trig-one. A cerebral angiogram showed tumor staining in the same area. Subtotal tumor resection was performed uneventfully. The microscopic diagnosis was glioblastoma multiforme. Postoperatively, the patient underwent whole brain and local irradiation, and intra-arterial ACNU infusion therapy. One month later, she developed low back pain, probably due to spinal dissemination. Postmortem examination showed local recurrence of the tumor and subarachnoidal dissemination not only in the base of the skull but in the lower spinal cord. Tumor was also observed in the liver, but no lung or lymph node metastasis was detected. Metastasis to the liver in this patient is believed to have occurred via the anastomosis between the vertebral and portal venous system.
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PMID:[Glioblastoma multiforme with liver metastasis--case report]. 754 23


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