Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is a detailed clinical and autopsy documentation of a rare entity--primary cardiac myxosarcoma in a 29-month-old girl. The patient had sudden onset of right hemiplegia and angiographic evidence of multiple occlusions of the left middle cerebral artery. Subsequent M-mode and sector echocardiography showed a mobile, pedunculated left atrial tumor, which was excised. No other tumor mass was noted at the time of surgical exploration, and postoperatively, the patient received a course of chemotherapy (vincristine, dactinomycin, and cyclophosphamide). After a temporary improvement in her condition, the patient died following several days of rapid deterioration; this was 3 months after the onset of symptoms. Autopsy showed that death was due to brainstem herniation secondary to massive infiltration of the brain by tumor, and there were also widespread systemic metastases.
 ...
PMID:Primary cardiac myxosarcoma in a child. 42 7

As a casuistic contribution to differential diagnosis of thrombosis of cerebral veins and sinuses a case of occlusion of sinus sagittalis superior by infiltration of an intracerebral metastasis from a teratoma of testis is reported. The leading symptoms - epileptic seizures, progressive hemiplegia, choked papilla and clouding of consciousness - gave rise to the tentative diagnosis of a cerebral tumor; in carotis angiography however, the metastasis was not detected, merely the occlusion of the sinus was demonstrated. Therefore the progress of the syndrome was misinterpreted as caused by an advancement of a venous thrombosis. Only autopsy showed the symptomless primary tumor and its formation of metastases.
 ...
PMID:[Occlusion of sinus sagittalis superior by infiltration of a tumor metastasis (author's transl)]. 104 Dec 51

Among 50 geriatric inpatients (average age 79) with late-onset epilepsy (average duration two years), 28 had grand mal attacks, 12 had focal attacks, seven had both. None had petit mal, confirming its rarity in the elderly. The epilepsy followed cerebrovascular disease (usually with hemiplegia) in 21 patients (8 per cent of all our patients with hemiplegia in the two-year study period developed epilepsy). Associated conditions included dementia in seven; and cerebral tumours (usually metastases) in five. This latter group survived less than two months on average from the onset of their attacks. The majority of patients (42 out of 50) were unfit for full neurological investigation; and the dangers of some procedures in the elderly are stressed.
 ...
PMID:Epilepsy in the elderly. 421 45

Two cases of paratesticular rhabdomyosarcoma were reported. One was a 53-year-old male, who was admitted to the Hospital because of swelling of the scrotum, hemosputa, and complete left hemiplegia. Clinical diagnosis was testicular tumor with remote metastases to lung, brain, liver, and para-aortic lymph nodes. At operation, tumor of 340 g of the paratesticular appendage was removed. Pathological findings of the tumor revealed rhabdomyosarcoma of mixed pleomorphic and embryonal types. The other was a 32-year-old male, who was admitted to the Hospital because of left inguinal and scrotal masses. The patient had a history of bruise at the left inguinal region about 5 years prior to admission. An orchiectomy and an excision of the inguinal tumor were performed. Histologically, the tumor was rhabdomyosarcoma of pleomorphic type. Clinical and pathological features of this rare tumor were discussed with a review of literature.
 ...
PMID:Paratesticular rhabdomyosarcoma. 662 57

A review of 10 years experience with prostatic carcinoma was undertaken with a search for neurologic complications. An unusual case presenting with symptoms of hemiplegia is reviewed. Of 154 charts, 90 provided adequate clinical information for complete analysis. Nineteen cases with neurologic complications were found and were restricted entirely to advanced (stages C and D) disease. Thirty-seven percent of patients with advanced disease developed neurologic complications. The most frequent complaints were related to organic brain syndrome, paraplegia, and radiculopathy. Eight patients developed peripheral nerve or spinal cord injury related to metastatic disease. Five patients suffered metabolic or paraneoplastic complications; three patient's symptoms related to central or epidural metastases and two patients developed neurologic symptoms related to complications of therapy. All neurologic symptoms improved given appropriate diagnosis and treatment. A brief review of the literature is included emphasizing the diverse nature of neurologic complications in this common neoplasm.
 ...
PMID:Neurologic complications in prostatic carcinoma. 732 73

A 29-year-old woman experienced abdominal swelling 12 years after undergoing partial thyroidectomy for follicular carcinoma of the thyroid with vascular invasion and 6 months after a right cerebral tumor that had caused hemiplegia had been excised. Laparotomy disclosed a solid and cystic right ovarian tumor, 17 cm in greatest dimension, and a 12-cm tumor of the right adrenal gland. Microscopic examination showed a malignant tumor of the thyroid follicular type with frequent mitotic figures; other teratomatous elements were absent. Because of the interval since the thyroid cancer, the diagnosis of a malignant struma ovarii was initially considered. The patient rapidly developed widespread metastatic disease and died, supporting the interpretation that the ovarian tumor was a metastasis from the thyroid neoplasm. This case illustrates that when other teratomatous elements are not identified, the diagnosis of malignant struma ovarii should be made only when the possibility of spread from a prior thyroid neoplasm, possibly one treated many years previously, has been excluded.
 ...
PMID:Ovarian metastasis from thyroid carcinoma 12 years after partial thyroidectomy mimicking struma ovarii: report of a case. 800 40

Non-bacterial thrombotic endocarditis was found at autopsy in a 17 year old male patient of fibrolamellar type of hepatocellular carcinoma with pericardial metastases. This had resulted in multiple embolic cerebral infarcts with long standing hemiplegia and later death due to acute left ventricular failure.
 ...
PMID:Fibrolamellar carcinoma of the liver--an unusual presentation. 805 51

We report a 36-year-old woman with right hemiplegia, anosognosia, and rapidly deteriorating course. She was well until the end of January, 1995 when she had an onset of fever, sputum, and cough. A 5 x 5 tumor was found in her left lower lobe. She was admitted to the Pulmonary Medicine on May 24, 1995 when she was 36-year-old. General physical examination was unremarkable. Bone scintigraphy revealed increased uptake in the skull, sternum, right scapula, vertebrae, right femur, and in ribs. Cranial CT scan revealed a large mass lesion in the right frontal subcortical region with central low density and peripheral high density areas, and small low density lesions in the right thalamic area and in the right posterior frontal region; ring enhancement was observed in the latter two lesions. On the second day of admission, she noted left-sided weakness which improved by corticosteroid treatment. On June 17, there was a sudden onset of left hemiparesis and a neurologic consultation was asked. Upon neurologic examination, she appeared somnolent but could understand verbal commands. She showed constructional apraxia, neglect of the left hemisphere, and anosognosia. Cranial nerves were unremarkable. Motor-wise, she showed flaccid left hemiplegia. Deep tendon reflexes were exaggerated on the left and the plantar response was extensor bilaterally. Nuchal stiffness was noted. Her cranial CT scan on June 17 revealed enlargement of the right frontal mass lesion. The subsequent course was complicated by DIC and progressive worsening of her consciousness. On June 18, she was comatose and pupillary light reflex was lost. She developed Cheyne-Stokes respiration and expired on that evening. The patient was discussed in a neurological CPC, and the chief discussant arrived at the conclusion that the patient had a primary adenocarcinoma in the lung with multiple metastases including the brain. The fulminant terminal course was ascribed to hemorrhage within the tumor and subsequent central type of transtentorial herniation. Opinions were divided regarding the cause of hemorrhage; some participants thought hemorrhage was caused by DIC. Post-mortem examination revealed an adenocarcinoma arising at the S6 segment of the left lung with multiple organ metastases. In the brain, a huge hemorrhagic metastasis was found in the right frontal lobe and a non-hemorrhagic metastasis in the right thalamic region. Probably, the size of the metastases influenced the occurrence of hemorrhage. The direct cause of the death was transtentorial herniation.
 ...
PMID:[A 36-year-old woman with acute onset left hemiplegia and anosognosia]. 912 37

A 53-year-old woman had a left hemiplegia with suspicion of cerebral metastases. Thoracic and abdominal computed tomography revealed renal and splenic infarction features and she presented violaceous papulosis on her fingers corresponding to thrombosis of dermal vessels. Echocardiography showed a left atrial tumor evoking myxoma. The clinical features of left atrial myxomas are intracardiac obstruction, extracardiac embolism and general symptoms. Cutaneous manifestations are frequently reported and can correspond to cutaneous manifestations of emboli, symptoms related to auto-immune disorders and specific cutaneous findings that suggest atrial myxoma as part of more complex syndromes.
 ...
PMID:Cutaneous manifestation of left atrial myxoma. 1058 36

A 59-year-old male visited us with a chief complaint of dysuria. The serum prostate specific antigen (PSA) level was within normal limits, and intravenous pyelography and urethrocystography showed no abnormal findings. Because of his urinary retention, transurethral resection of prostate was performed under a clinical diagnosis of benign prostatic hyperplasia. The pathological diagnosis was poorly differentiated adenocarcinoma of the prostate. Not only combination hormone therapy with goserelin acetate and flutamide, but also intermittent arterial infusion chemotherapy with cisplatin (CDDP) and pirarubicin (THP) using a reservoir system was administered. Additionally total pelvic irradiation was delivered. Magnetic resonance imaging (MRI) demonstrated that his prostate was reduced to less than 50% in size and he had no difficulty in voiding. He suddenly developed dysarthria and hemiplegia 3 months later. MRI and computed tomography (CT) revealed multiple brain metastases. After the gamma knife radiosurgery, neurological findings disappeared and MRI showed dramatic shrinkage of metastatic brain tumors. Metastasis to the pancreas was recognized on CT and he died of multiple organ failure 30 months after his first visit.
 ...
PMID:[Complete remission of brain metastases from prostate cancer by gamma knife radiosurgery: a case report]. 1143 55


1 2 3 Next >>