Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0027627 (metastases)
 103,950 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To ascertain the range of neurological problems in patients with systemic cancer, we prospectively evaluated neurological symptoms, neurological diagnoses, and primary tumors in all patients with a history of systemic cancer examined by the Department of Neurology at the Memorial Sloan-Kettering Cancer Center, from Jul 1, 1990, to Dec 31, 1990. Of the 815 patients seen for neurological symptoms, less than half (45.2%) had metastatic involvement of the nervous system. The three most common symptoms were back pain (18.2%), altered mental status (17.1%), and headache (15.4%). The most common neurological diagnosis was brain metastasis (15.9%), followed by metabolic encephalopathy (10.2%), pain associated with bone metastases only (9.9%), and epidural extension or metastasis of tumor (8.4%). Of 133 patients with undiagnosed back or neck pain, 44 (33%) had epidural extension or metastases from tumor and 40 (30%) had pain associated with vertebral metastases only. In 15 (11%) the cause for the back pain was unrelated to metastatic disease. Of 132 patients seen on initial consultation for altered mental status, metabolic encephalopathy was the major neurological diagnosis (80; 61%); 20 (15%) had intracranial metastases. Of 97 patients with undiagnosed headache, 59 (61%) had a nonstructural cause. Fifty-three of these patients had either migraine, tension headache, or headache related to systemic illness (e.g., fever, sepsis). These results indicate that even in patients with systemic cancer, a group particularly prone to developing neurological disease that can be diagnosed radiologically, the role of clinicians remains important in helping distinguish noncancer-related and nonmetastatic neurological problems.
 ...
PMID:The spectrum of neurological disease in patients with systemic cancer. 163 35

Pain is the earliest and most prominent feature of symptomatic spinal metastases. In some cases, pain may have been present for months and dismissed as arthritis or back strain. Local back or neck pain occurring in a cancer patient is due to spinal metastasis until proved otherwise. Once weakness occurs, the disease progresses to paraplegia unless treatment is undertaken. Pedicle erosion is the most common abnormality on spinal films. Irradiation is often effective, but surgery is indicated for radiation failure, unknown diagnosis, pathologic fracture-dislocation and rapid disease progression.
 ...
PMID:Symptomatic spinal metastases. 252 57

Rheumatoid arthritis and metastatic cancer occur commonly in the elderly, and may cause neck pain. Rheumatoid arthritis may produce cervical radiculopathy and myelopathy resulting from vertebral body subluxation, although radiological manifestations of subluxation are much more common than neurological dysfunction. Cervical spinal cord compression is a neurological emergency and may produce cervical radiculopathy as well as myelopathy. Careful neurological and radiological assessments are required to minimize pain and preserve neurological function in elderly patients suffering from neck pain complicating rheumatoid arthritis or cervical spinal metastasis.
 ...
PMID:Neck pain in the elderly: a management review. Part II. 380 32

Among 137 patients with small cell carcinoma of the lung (SCCL) treated on two consecutive protocols, leptomeningeal metastases were documented in 12 patients (9%), 10 antemortem by cerebrospinal fluid (CSF) cytology, one by myelogram, and one only at necropsy. Signs and symptoms included confusion in seven, limb weakness in six, paresthesias in three, headache in two, urinary incontinence in two, and nausea and vomiting, diplopia and neck pain in one patient each. Nine of the 12 patients had evidence of other metastases while three patients relapsed first in the CSF and one had disease only in the leptomeninges. Treatment for this complication including irradiation, intrathecal chemotherapy, or systemic chemotherapy was generally ineffective with a median duration of survival of 50 days (range 5 to 130) after diagnosis of leptomeningeal. Necropsies showed thick tumor deposits along cord, distal nerve roots, cauda equina, and in Virchow--Robbins spaces with deep invasion into adjacent neural substance in six of the seven. Leptomeningeal involvement appears to have become manifest as median survival has increased. CSF cytology should therefore be examined in patients who develop unusual neurological findings during the course of this disease and methods of prevention may need to be considered in future studies.
 ...
PMID:Leptomeningeal carcinomatosis in small cell carcinoma of the lung. 625 38

A series of 18 patients with odontoid fractures due to metastatic cancer were treated at Memorial Sloan-Kettering Cancer Center between 1974--1980. The primary source of cancer was breast (12 cases), lung (two cases), nasopharynx (one case), multiple myeloma (one case), colon (one case), and rhabdomyosarcoma (one case). The clinical features consisted of severe neck pain and neck stiffness in 17 patients; signs of cord compression were noted in only four patients. Tomography and computerized tomography were useful in identifying both the osseous and soft-tissue involvement by tumor. Initial treatment in all patients except those with myelopathy consisted of high-dose steroids, and immobilization in a hard collar. Ten patients were treated with radiation therapy alone; six patients underwent surgical fusion (four before and two after radiation therapy); and two patients died before completion of treatment. Conservatively treated patients were allowed to walk with the support of only a collar following radiation therapy. We believe that the initial management of patients with odontoid fractures secondary to cancer should be high-dose steroids and radiation therapy, unless displacement is marked. Assessment for surgical fusion should be made following radiation therapy, since conservative treatment may suffice in most patients. Early recognition is important so that treatment can be instituted before C1--2 subluxation becomes severe.
 ...
PMID:Treatment of odontoid fractures in cancer patients. 745 32

A retrospective review of 36 patients treated with posterior cervical plating and autogenous iliac crest bone graft was performed to evaluate the results of posterior cervical plating in terms of fusion, outcome, technique, and complications. Numerous methods of cervical stabilization have been described with varying fusion rates and complications. Compared to wiring techniques, there is little information concerning the results of posterior cervical plating. Thirty-six patients with cervical instability underwent posterior plating with lateral mass screw fixation. Twenty-two had acute traumatic instability, four had late traumatic instability, six had metastatic disease, and four had postlaminectomy spondylotic instability. A Minerva brace was worn postoperatively for 3 months and fusion was assessed by bone incorporation on plain films, stable dynamic flexion-extension views, and absence of neck pain. Postoperative MRI and CT imaging was assessed in those patients who underwent these modalities. Fusion occurred at an average of 3 months in all patients. One patient demonstrated postoperative neurologic deterioration, but this resolved with subsequent decompression. Six patients had loosening of short, unicortical screws, but this did not affect the fusion result in five of these patients. The use of titanium implants allowed operative CT and MR imaging without the excessive artifact associated with stainless steel implants. Posterior cervical plating with lateral mass fixation and bone grafting offers a reliable method of achieving fusion. Bicortical lateral mass screws are less likely to loosen than unicortical screws, and no major complications occurred.
 ...
PMID:Posterior plating of the cervical spine. 760 16

A retrospective study of 13 patients with metastases to the upper cervical spine was designed to examine the clinical efficacy of surgical treatment. All patients had severe neck pain and two had quadriplegia. Eleven patients underwent operative posterior stabilization, and two patients were treated with a brace and radiotherapy. Pain relief after surgery was significant so that 10 of the 11 patients could leave bed and resume their normal activities. The other two patients who were treated nonoperatively had severe dementia and sudden death from a respiratory arrest after a fall, despite temporary relief from pain. Surgery may be very successful in improving the quality of life of patients who have pain and/or paralysis caused by metastases to the upper cervical spine.
 ...
PMID:Metastases to the upper cervical spine. 885 73

Neck and back pain are frequent complaints of patients with pediatric cancer, second only to headaches as a cause of neurologic consultation. The importance of this symptom, however, has not been studied in the pediatric cancer patients. This report is a review of the consultations as a result of neck and back pain in patients with pediatric cancer, with analysis of clinical presentation, etiology, underlying cancer, and neuroradiologic findings. The etiology of the complaint varied with the underlying cancer, although metastatic disease to the spine was frequent in patients with solid tumors, in younger children, and in patients admitted to the hospital. Back or neck pain is a serious complaint in children with systemic cancer, because the incidence of metastatic disease is high. Magnetic resonance imaging of the whole spine should be obtained if metastatic disease can not be excluded clinically, particularly for young patients and in children with advanced disease.
 ...
PMID:Back and neck pain in children with cancer. 1216 Sep 73

We reviewed clinical data from eight patients with upper cervical metastases who were treated with an occipitocervical fusion procedure using Luque's segmental spinal instrumentation with a fan-shaped rod. All patients had diffuse involvement of the entire anterior vertebral body, extreme instability at C1/2, and severe preoperative neck pain, but no neurological deficits. This procedure provided significant postoperative pain relief, with only one patient experiencing deterioration. The activities of daily living (ADL) levels of four patients improved; ADLs in four patients who were severely impaired were unchanged. Even though tissue destruction continued after surgery, this procedure prevented further deformity and instability. There were two major surgical complications: respiratory quadriplegia and hydro-cephalic coma. Great care must be taken to avoid these problems. Of the various instrumentation possibilities now available, we strongly advocate consideration of this particular stabilization procedure for upper cervical metastases to provide dying patients with an optimal quality of life during their final days.
 ...
PMID:Clinical evaluation of Luque's segmental spinal instrumentation for upper cervical metastases. 1266 49

Spinal metastases are commonly encountered by physicians in a variety of clinical fields. There are some controversies in choice of treatment between surgery and radiotherapy. This report is a study of the outcomes of radiotherapy for metastatic nonround cell tumors of the spine. Medical records and films of 31 patients who were treated with radiotherapy at Songklanakarind Hospital were retrospectively reviewed. The most common primary tumors were prostate and breast. One patient had spinal metastases from malignant serous cystadenoma of the fallopian tube of which no previous report has been published. This patient had excellent results after radiotherapy. Back and neck pain were the primary symptoms of the patients, while motor or sensory deficits (or both) were found in 58 per cent of the cases. Seven patients had neurological recovery and 18 patients had pain relief after radiotherapy. Cause of compression is the only factor effecting the result from univariate and multivariate analysis. Spinal cord compressed by a tumor had a better recovery than those which were compressed by a bony fragment or intervertebral disc. The authors concluded that radiotherapy remains a good treatment for patient with non round cell spinal metastasis. Cause of spinal cord compression is the only factor predicting the result of treatment.
 ...
PMID:Results of radiotherapy in non round cell spinal metastasis. 1511 39


1 2 3 4 Next >>